Effects of repeated blood donations on iron status and hematologic variables of canine blood donors

Ferreira, Ricardo Artur Sanguinetti; Gopegui, Rafael Ruiz de; Araujo, Maria Manuela R C; Matos, Augusto J. F. de

doi:10.2460/javma.244.11.1298

Cited by 13 publications

(9 citation statements)

References 22 publications

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“…Baseline MCF ex‐TEM was significantly lower in the LRS treatment group compared to controls (62 ± 2.4 versus 57.8 ± 4.7 mm, P = 0.01), and this difference could have biased subsequent comparisons between the LRS treatment and the other treatment groups. Although this difference could suggest that the washout intervals between experiments that involved hemorrhage and VR (8 weeks) might not have been long enough to completely eliminate a carryover effect, this interval far exceeds the period required by the bone marrow to restore the depleted cells after blood donation in dogs (10 days) . The difference in MCT ex‐TEM was relatively small and might have been caused by type II error.…”

Section: Discussionmentioning

confidence: 99%

Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs

Diniz

Neto

Gonçalves

et al. 2018

Veterinary Internal Medicne

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BackgroundTetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine.ObjectiveCompare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs.AnimalsSix healthy English Pointer dogs (19.7‐35.3 kg).MethodsProspective crossover study. Dogs were anesthetized without hemorrhage and VR (control). Two weeks later, dogs were hemorrhaged under anesthesia on 2 occasions (8‐week washout intervals) and randomly received VR with LRS or TS at 3:1 or 1:1 of shed blood, respectively, aiming to decrease the hematocrit to 33%. Rotational thromboelastometry and other coagulation variables were determined before 0.5, 2, and 4 hours after VR during anesthesia and 24 hours after VR (conscious dogs).ResultsBuccal mucosal bleeding time did not differ between treatments after VR. Activated partial thromboplastin time increased from controls 4 hours after TS (P = 0.045). Clot formation time (CFT) and alfa‐angle increased from controls from 0.5 to 4 hours after LRS (CFT, P ≤ 0.0001‐0.02; alpha angle, P = 0.0001‐0.02) and from 0.5 to 2 hours after TS (CFT, P = 0.0002‐0.01; alpha angle, P = 0.0005‐0.02). The maximum clot firmness decreased from controls from 0.5 to 4 hours after LRS (P ≤ 0.0001‐0.01) and TS (P ≤ 0.0001‐0.04).Conclusions and Clinical RelevanceTetrastarch does not impair primary hemostasis and induces transient dilutional coagulopathy that is similar to LRS because, when compared to a 3 times higher volume of LRS in hemorrhaged dogs, it does not cause greater interference on the viscoelastic properties of the coagulum.

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Section: Discussionmentioning

confidence: 99%

Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs

Diniz

Neto

Gonçalves

et al. 2018

Veterinary Internal Medicne

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“…Notably, traditional markers of iron deficiency (including MCV, serum ferritin, and serum iron) were not different between the donor and control groups. Although both previous studies examining iron status in blood donor dogs have reported changes suggesting iron deficiency,14, 15 our study uses RBC and reticulocyte indices support the diagnosis of iron deficiency and IDE.…”

Section: Discussionmentioning

confidence: 78%

“…Depleted blood cells can be restored within 10 days of donation,15 suggesting that the interval between donations is adequate. However, repeated donation leading to IDE might permit only a blunted regenerative response.…”

Section: Discussionmentioning

confidence: 99%

“…The automated reticulocyte count in our study was evaluated immediately before a donation, or approximately 7 weeks after a donation, therefore the reticulocyte count might have been increased above the control group in the days immediately after donation. Ten days after donation, dogs had a mean manual reticulocyte count of 91,203/μL after donating 13% TBV every 2 months for 1 year 15. Although the precise volume of blood donated was not recorded for the purposes of this study, our donation goal was 400–450 mL.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Iron Deficiency Using Reticulocyte Indices in Dogs Enrolled in a Blood Donor Program

Foy

Friedrichs

Bach

2015

Veterinary Internal Medicne

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BackgroundPeople donating blood more than twice annually are at risk of developing iron deficiency. Little is known about the iron status of dogs enrolled in blood donor programs.HypothesisDogs donating blood ≥6 times annually will show evidence of iron deficiency based on their reticulocyte indices.AnimalsThirteen dogs enrolled in a blood donor program donating ≥6 times over the preceding 12 months and 20 healthy nondonor control dogs.MethodsProspective observational study. Mature red blood cell (RBC) indices, reticulocyte indices, serum iron, serum ferritin, and total iron‐binding capacity (TIBC) were compared between groups.ResultsPacked cell volume (median 47%, range 40–52%, P < .01), hematocrit (median 46.4%, range 40.3–52.5%, P < .01), and reticulocyte count (median 16,000/μL, range 9,000–38,000/μL, P < .01) were significantly lower in the blood donor dogs. No statistically significant differences were noted in the mature RBC indices between groups. Both reticulocyte mean corpuscular volume (median 88.8 fL, range 83.4–95.5 fL, P = .03) and reticulocyte hemoglobin content (median 24.6 pg, range 23.1–26.6 pg, P < .01) were significantly lower in the blood donor group. Serum iron and ferritin were similar between groups; however, TIBC was significantly higher in the control group (median 403 μg/dL, range 225–493 μg/dL, P = .02).ConclusionsThe findings in dogs donating ≥6 times annually suggest the presence of iron‐deficient erythropoiesis in this population.

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“…Adult RIs are representative when the population they refer to is composed of healthy subjects [ 30 ], and the use of a blood donor database can ensure this prerogative, since hematology and clinical biochemistry present a fundamental support to evaluate the health status of blood donors in a Veterinary Blood Bank [ 5 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Hematological and Biochemical Reference Intervals for 5 Adult Hunting Dog Breeds Using a Blood Donor Database

Miglio

Gavazza

Siepi

et al. 2020

Animals

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Numerous studies have shown the importance of breed-related differences between hematological and biochemical results in veterinary medicine. The aim of this study is to determine hematologic and biochemical Reference Intervals (RIs) for 5 hunting dog breeds from a blood donor database, adopting an indirect sampling method, and to compare them with laboratory established and published RIs to identify possible breed and attitude-related differences. The study analyzed the blood parameters of 445 adults (222 females and 223 male, with age ranging from 2 to 8 years, mean age 5.3 years), client-owned, clinically healthy blood donor dogs of 5 breeds: 156 Ariégeois, 52 Bleu de Gascogne, 64 Bracco italiano, 123 Segugio italiano, and 50 Briquet Griffon Vandeen. Statistical analysis was performed as recommended by the American Society of Veterinary Clinical Pathology (ASVCP) guidelines. RIs for red blood cells (RBC), hematocrit (HCT), hemoglobin (HB), main corpuscular volume (MCV), main corpuscular hemoglobin (MCH), main corpuscular hemoglobin concentration (MCHC), red distribution widht (RDW), white blood cells (WBC), and differential leukocytes count, PLT, Albumin, Total Protein, Urea, Creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) for each of the 5 breeds were performed, and significant differences with the established RIs were detected. We found significant differences in 12 hematologic and serum biochemical analytes for which a breed-specific variation appears to be the most plausible explanation. New RIs for HCT, MCH, MCHC, RDW, PLT, Monocytes, Eosinophils, Albumin, Urea, Creatinine, AST, and ALT are provided for at least 1 breed. Breed-specific RIs for adult hunting dogs will help avoid misinterpretation of laboratory results in these breeds.

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Effects of repeated blood donations on iron status and hematologic variables of canine blood donors

Cited by 13 publications

References 22 publications

Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs

Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs

Evaluation of Iron Deficiency Using Reticulocyte Indices in Dogs Enrolled in a Blood Donor Program

Hematological and Biochemical Reference Intervals for 5 Adult Hunting Dog Breeds Using a Blood Donor Database

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