2015
DOI: 10.1080/02640414.2015.1004637
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Effects of repeated bouts of long-duration endurance exercise on muscle and urinary levels of 8-hydroxy-2ʹ-deoxyguanosine in moderately trained cyclists

Abstract: The purpose of this study was to determine the effects of repeated bouts of long-duration endurance exercise on both muscle and urinary levels of oxidative DNA damage in moderately trained individuals. Seven moderately trained male cyclists participated in this study. All participants repeated two sessions consisting of a 5 hour cycling period (equivalent to approximately 52% VO2peak) followed by a 15 hour rest, then a 40 km time trial. During the sessions, participants were instructed to take water ad libitum… Show more

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Cited by 10 publications
(7 citation statements)
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“…DNA damage is measured with an increase in 8-hydroxy-2 -deoxyguanosine (8-OHdG) plasma levels because the activity of several DNA-repairing enzymes (among them: human 8-oxoguanine DNA glycosylase1 and oxidized purine-nucleoside triphosphate) is increased to protect against exercise-induced DNA damage. Yasuda et al [53] determined the effects of two races of endurance exercise on oxidative DNA damage in trained cyclists. No cumulative effects at the muscle or urinary levels of 8-OHdG between two repeated sessions were found, probably due to the adaptive response dependent on the athlete's training state.…”
Section: Redox Homeostasis and Oxidative Stress In Sportsmentioning
confidence: 99%
“…DNA damage is measured with an increase in 8-hydroxy-2 -deoxyguanosine (8-OHdG) plasma levels because the activity of several DNA-repairing enzymes (among them: human 8-oxoguanine DNA glycosylase1 and oxidized purine-nucleoside triphosphate) is increased to protect against exercise-induced DNA damage. Yasuda et al [53] determined the effects of two races of endurance exercise on oxidative DNA damage in trained cyclists. No cumulative effects at the muscle or urinary levels of 8-OHdG between two repeated sessions were found, probably due to the adaptive response dependent on the athlete's training state.…”
Section: Redox Homeostasis and Oxidative Stress In Sportsmentioning
confidence: 99%
“…No firm relationship between exercise and oxidative damage can be described, but there is a tendency of increased 8-OHdG levels during extensive exercise. In contrast to children, physically active middle-aged subjects had consistently higher urinary 8-OHdG levels than sedentary individuals [ 62 , 63 , 64 ].…”
Section: Discussionmentioning
confidence: 99%
“…A detailed analysis was conducted by subgroup analysis to compare the differences against pre-exercise baseline in the 1) type of exercise (resistance and aerobic), 2) training status, 3) duration of aerobic exercise, and 4) intensity of aerobic exercise. Due to the limited number of literature works available, 8-OHdG in muscle samples was included only in the systematic review (Radák et al, 1999;Fogarty et al, 2013;Yasuda et al, 2015).…”
Section: Data Synthesis and Analysismentioning
confidence: 99%
“…A total of 16 studies (431 participants) were finally included for the meta-analysis after exclusion of three long-term training studies (Margaritis et al, 2003;Mrakic-Sposta et al, 2015;Atli, 2021), three studies involved with Wingate tests (Cuevas et al, 2005;Shi et al, 2007;Serkan, 2011), four studies not reporting exercise intensity (Inoue et al, 1993;Asami et al, 1998;Hamurcu et al, 2010;Meihua et al, 2018), and four studies not reporting the exercise protocol (Giacomo et al, 2009;Mergener et al, 2009;Aires et al, 2010;Neubauer et al, 2010). Studies reporting the levels of 8-OHdG in human skeletal muscle were used for the systematic review (Radák et al, 1999;Yasuda et al, 2015). Frontiers in Physiology frontiersin.org…”
Section: Selection Processmentioning
confidence: 99%
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