Effects of Repeated Chair Restraint on Physiological Values in the Rhesus Monkey (&lt;I&gt;Macaca mulatta&lt;/I&gt;)

Tatsumi, Tetsuo; Koto, Masao; Komatsu, Hikosaburo; Adachi, Jiro

doi:10.1538/expanim1978.39.3_361

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…Tatsumi et al. reported a slight increase in serum AST at the beginning of 8‐hour monkey‐chair restraint, and concluded its increase to have been derived from muscle activity consequent to excitement during the restraint [34]. In our present study, however, AST did not change throughout the experiment, nor did ALT.…”

Section: Discussioncontrasting

confidence: 70%

“…AST in the blood is mainly derived from heart, liver, and muscle; whereas ALT is derived from the liver. Tatsumi et al reported a slight increase in serum AST at the beginning of 8-hour monkey-chair restraint, and concluded its increase to have been derived from muscle activity consequent to excitement during the restraint [34].…”

Section: Discussionmentioning

confidence: 99%

“…First, the duration needed for adequate acclimation may vary according to the acclimation method. Tatsumi et al reported that continuous 8-hour restraint had great effects on ECG and blood pressure measurements [34]. Therefore, longer restraint may more effective; however, the ethical aspect must be considered.…”

Section: Discussionmentioning

confidence: 99%

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Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Hassimoto

Harada

2004

J of Medical Primatology

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The aim of this study was to determine if 6-month acclimation would enable accurate evaluation of hematological, biochemical data, and ECG recorded under restraint for conscious rhesus monkeys of both sexes. Periodic evaluation of these parameters was made during the 6-month period of acclimation. The platelet count, alkaline phosphatase, glucose, and sodium levels significantly decreased, whereas creatinine increased, compared with pre-acclimation values. The heart rate was significantly reduced compared with pre-acclimation values. QT-RR relation followed the square root regression function, which means modification of Bazett's QTc formula can be applied even if the ECG is recorded under restraint. In conclusion, 6-month acclimation was effective for stabilizing the blood data and for allowing accurate evaluation of the ECG even under restraint. Current results show that an acclimation period at least 3 months may be necessary prior to using rhesus monkeys for chronic studies.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Hassimoto

Harada

2004

J of Medical Primatology

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“…In our study estimated pulse rates were in the range of 95-125 BPM for monkey Sun, 125-150 BPM for Fla and 160-230 BPM for Mag, which agrees with previously reported values of heart rate (120-250 BPM) for rhesus monkeys sitting in a primate chair [2,[33][34][35]. Performance of our method for pulse rate estimation (Table 4) was only slightly worse than those reported for humans: mean absolute error obtained in [70] was 2.5 BPM; fraction of epochs with error below 6 BPM (about 8% of average human pulse rate) for the best method considered in [71] was achieved for 87% of epochs; reported values of the Pearson correlation coefficient vary from 0.87 in [71] to 1.00 in [25].…”

Section: Pulse Rate Estimationsupporting

confidence: 92%

“…To estimate pulse rate from iPPG (videoPR) we computed the discrete Fourier transform (DFT) of iPPG signal in sliding overlapping windows; for each window pulse rate is estimated by the frequency with highest amplitude in the heart-rate bandwidth, which is 90-300 BPM (1.5-5 Hz) for rhesus monkeys [2,[33][34][35]. This approach is commonly used for human iPPG [22,24,25], so we applied it here to make our results comparable.…”

Section: Materials and Set-upmentioning

confidence: 99%

Using imaging photoplethysmography for heart rate estimation in non-human primates

Unakafov

Moeller

Kagan

et al. 2018

Preprint

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For humans and for non-human primates heart rate is a reliable indicator of an individual's current physiological state, with applications ranging from health checks to experimental studies of cognitive and emotional state. In humans, changes in the optical properties of the skin tissue correlated with cardiac cycles (imaging photoplethysmogram, iPPG) allow non-contact estimation of heart rate by its proxy, pulse rate. Yet, there is no established simple and non-invasive technique for pulse rate measurements in awake and behaving animals. Using iPPG, we here demonstrate that pulse rate in rhesus monkeys can be accurately estimated from facial videos. We computed iPPGs from seven color facial videos of three awake head-stabilized rhesus monkeys. Pulse rate estimated from iPPGs was in good agreement with reference data from a pulse-oximeter with error of pulse rate estimation below 5% for 82% of all epochs, and below 10% for 98% of the epochs. We conclude that iPPG allows non-invasive and non-contact estimation of pulse rate in non-human primates, which is useful for physiological studies and can be used toward welfare-assessment of non-human primates in research.

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Behavioral and cortisol responses to repeated capture and venipuncture inCebus apella

et al. 1996

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Eight capuchins were trained in a capture and venipuncture procedure. Samples taken immediately following capture indicated that subjects experienced rising cortisol levels over the first 5 weeks of training followed by a return to baseline (equivalent to day 1 levels) in the sixth and seventh weeks. After 7 weeks, samples taken 60 min after initial capture revealed that behaviorally habituated animals exhibited significantly lower cortisol levels in response to venipuncture as opposed to naive and experienced but nonbehaviorally habituated subjects. © 1996 Wiley‐Liss, Inc.

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Effects of Repeated Chair Restraint on Physiological Values in the Rhesus Monkey (<I>Macaca mulatta</I>)

Cited by 9 publications

References 10 publications

Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Using imaging photoplethysmography for heart rate estimation in non-human primates

Behavioral and cortisol responses to repeated capture and venipuncture inCebus apella

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