Effects of repeated extracorporeal shock wave on kidney apoptosis of normal and diabetic rat

Kira, Vicente Massaji; Fagundes, Djalma José; Bandeira, César Orlando Peralta; Kaufman, Oskar; Fagundes, Anna Tereza Negrini; Ortiz, Valdemar

doi:10.1590/s1677-55382008000100013

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…Applied the number of shock waves and the level of energy were decided based on previous studies and our preliminary studies. 15,16 After SWT procedure, rats were returned to their cages.…”

Section: Swt Proceduresmentioning

confidence: 99%

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Fırat¹,

Malkoç

Demirer³

et al. 2014

Renal Failure

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Objectives: Shock wave lithotripsy treatment (SWT) is not completely free from side effects; one of the accused mechanisms for renal injury during SWT is oxygen-and nitrogen-derived free radical productions. Therefore, we aimed to evaluate the effect of inhibition of nitric oxide (NO) production by N-[3(aminomethyl) benzyl) acetamidine] (1400W), highly selective inducible nitric oxide synthase (iNOS) inhibitor, at SWT-induced kidney damage. Materials and methods: Twenty-four rats those underwent right nephrectomy procedure were divided equally into three groups as control, SWT, and SWT + 1400W. 1400W was administered at a dose of 10 mg/kg at 2 h prior to SWT procedure and at the beginning of SWT procedure via intraperitoneal route and continued daily for consecutive 3 days. At the end of the fourth day, animals were killed via decapitation and trunk blood and the left kidneys were taken for biochemical and histopathologic evaluation. Results: SWT caused renal tubular damage and increased lipid peroxidation and antioxidant enzyme activities and SWT also significantly increased nitro-oxidative products. Inhibition of iNOS via administration of 1400W ameliorated renal injury and decreased tissue lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase and nitrite/nitrate levels (NO x ). In addition, it was seen that histolopathological changes were attenuated in the SWT + 1400W group when compared to SWT group. Conclusion: SWT-induced renal injury might be due to excessive production of oxygen free radicals and NO production. Inhibition of iNOS attenuates renal injury following SWT treatment. It can be concluded that iNOS inhibitors or peroxynitrite scavengers might be used to protect the kidneys against SWT-induced morphological and functional injuries.

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“…Applied the number of shock waves and the level of energy were decided based on previous studies and our preliminary studies. 15,16 After SWT procedure, rats were returned to their cages.…”

Section: Swt Proceduresmentioning

confidence: 99%

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Fırat¹,

Malkoç

Demirer³

et al. 2014

Renal Failure

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“…Applied the number of shock waves and the level of energy were decided based on previous studies and our preliminary studies. [14][15][16][17] After ESW procedure, rats were returned to their cages.…”

Section: Induction Of Esw-induced Renal Injurymentioning

confidence: 99%

Efficacy of poly(adenosine diphosphate-ribose) polymerase inhibition in extracorporeal shock wave-induced renal injury

Malkoç

Fırat²,

Demirer

et al. 2014

Renal Failure

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Objectives: Extracorporeal shock wave lithotripsy (ESW) induces renal damage by excessive production of free oxygen radicals. Free Oxygen radicals cause cellular injury by inducing nicks in DNA. The enzyme poly(adenosine diphosphate-ribose) polymerase (PARP) involved in the process of repair of DNA in damaged cells. However, its activation in damaged cells can lead to adenosine triphosphate depletion and death. Thus, we designed a study to evaluate the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, against extracorporeal shock wave induced renal injury. Methods: Twenty-four Sprague-Dawley rats were divided into three groups: control, ESW, ESW + 3-AB groups. All groups except control group were subjected to ESW procedure. ESW + 3-AB group received 20 mg/kg/day 3-aminobenzamide intraperitoneally at 2 h before ESW and continued once a day for consecutive 3 days. The surviving animals were sacrificed at the 4th day and their kidneys were harvested for biochemical and histopathologic analysis. Blood samples from animals were also obtained. Results: Serum ALT and AST levels, serum neopterin and tissue oxidative stress parameters were increased in the ESW group and almost came to control values in the treatment group (p50.05, ESW vs. ESW + 3-AB). Histopathological injury score were significantly lower in treatment group than the ESW group (p50.05, ESW vs. ESW + 3-AB). Conclusion: Our data showed that PARP inhibition protected renal tissue against ESW induced renal injury. These findings suggest that it would be possible to improve the outcome of ESW induced renal injury by using PARP inhibitors as a preventive therapy.

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“…We are aware of only two reports showing that kidneys of alloxan-induced diabetic rats were more susceptible to the injurious effects of SWL than nondiabetic rats-greater degree of parenchymal hemorrhage and apoptosis, which was particularly evident after repeated SWL sessions. 26,27 If the damage to the renal parenchyma is permanent, and of sufficient magnitude, then undoubtedly there will be functional consequences. And, the potential for functional deterioration following SWL may be evident in the setting of CKD or compromised renal function.…”

Section: Discussionmentioning

confidence: 99%

Shock Wave Lithotripsy Does Not Impair Renal Function in a Swine Model of Metabolic Syndrome

Handa

Johnson

Connors

et al. 2015

Journal of Endourology

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Purpose: To determine whether shock wave lithotripsy (SWL) may be a risk factor for renal functional impairment in a swine model of metabolic syndrome (MetS). Materials and Methods: Nine-month-old female Ossabaw pigs were fed an excess calorie atherogenic diet to induce MetS. At 15 months of age, the MetS pigs were treated with 2000 SWs or an overtreatment dose of 4000 SWs targeted at the upper pole calyx of the left kidney (24 kV at 120 SWs/min using the unmodified Dornier HM3 lithotripter; n = 5-6 per treatment group). Serum creatinine (Cr) and blood urea nitrogen (BUN) levels were measured in conscious pigs before and *60 days after SWL to provide a qualitative assessment of how well both kidneys were filtering (glomerular filtration rate [GFR]). Bilateral renal function was assessed at *65 days post-SWL in anesthetized pigs with GFR and effective renal plasma flow (ERPF) quantified by the renal clearance of inulin and para-amino hippurate, respectively. Results: Cr and BUN values were within normal limits before SWL and remained unchanged after lithotripsy in both the 2000 SW-and 4000 SW-treated pigs. GFR and ERPF of kidneys treated with SWL at either SW dose were similar to the contralateral nontreated kidney. Chronic histological changes in the SW-treated pole of the kidney included interstitial fibrosis, sclerotic glomeruli, and dilated and atrophic tubules. Conclusions: Our results are consistent with the view that a single SWL session does not result in renal impairment, even in the presence of MetS.

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Effects of repeated extracorporeal shock wave on kidney apoptosis of normal and diabetic rat

Cited by 10 publications

References 17 publications

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Efficacy of poly(adenosine diphosphate-ribose) polymerase inhibition in extracorporeal shock wave-induced renal injury

Shock Wave Lithotripsy Does Not Impair Renal Function in a Swine Model of Metabolic Syndrome

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