Effects of repeated in vivo inhalant nitrite exposure on gene expression in mouse liver and lungs

Tran, Doanh; Brazeau, Daniel A.; Nickerson, Peter A.; Fung, Ho‐Leung

doi:10.1016/j.niox.2005.09.010

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…These effects may remain even after acute exposure to these substances of abuse. This view is supported by our recent finding that increased hepatic VEGF protein expression, as determined by immunohistochemistry, remained significantly elevated at 4 hr after nitrite exposure has been withdrawn (Tran et al 2006). Thus, the view that inhalant nitrites will not produce ill effects because of their rapid clearance is scientifically incorrect.…”

Section: Inhalant Nitrite Pharmacokinetics and Footprints Of Biochemimentioning

confidence: 89%

“…These results showed clearly that acute exposure to inhalant nitrites altered the regulation of several genes that are intimately involved in KS development. Immunohistochemical studies showed that stimulated VEGF protein expression in the liver resided primarily in the hepatocytes (Tran et al 2006).…”

Section: In Vivo Regulation Of Vegf Gene and Protein Expression By Inmentioning

confidence: 99%

“…Because inhalant nitrite abusers use this substance repeatedly, we examined the effects of repeated nitrite exposure on the expression of a panel of 94 cancer-and angiogenesis-related genes, using a low-density gene microarray (Tran et al 2006). If a twofold change was used as a threshold criterion, the results would indicate alteration in the expression of 65 and 23 genes, respectively, in mouse liver and lungs.…”

Section: In Vivo Regulation Of Vegf Gene and Protein Expression By Inmentioning

confidence: 99%

“…The stimulated gene expression by inhalant nitrites of proangiogenic genes such as those encoding VEGF, FGF1, FGF4, Hsp70, and HO-1, as well as an anti-angiogenic gene that encodes PF4 strongly suggested that ISBN indeed affects the angiogenesis cascade. Detailed discussions about the role of each of these genes in mediating nitrite inhalant effects have been presented (Tran et al 2006).…”

Section: In Vivo Regulation Of Vegf Gene and Protein Expression By Inmentioning

confidence: 99%

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Effects of Inhalant Nitrites on VEGF Expression: A Feasible Link to Kaposi's Sarcoma?

Fung

Tran

2006

Jrnl Neuroimmune Pharm

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Because inhalant nitrites (commonly known as "poppers") were thought to be rapidly cleared from the body, the lay literature has somewhat downplayed their toxicity. However, scientific reports have documented their immunosuppressive effects in animals, and epidemiological studies have implicated their use with the development of Kaposi's sarcoma (KS) in humans. Because inhalant nitrites are exogenous nitric oxide donors, we hypothesized that these substances of abuse might exert part of their toxicological effects through this biochemical product, which has been shown to alter gene regulation and angiogenesis. In a series of studies, we showed that acute and chronic in vivo exposure to isobutyl nitrite (a representative inhalant nitrite) produced significant tissue-dependent alterations in the expression of a number of cancer- and angiogenesis-related genes in mice. In particular, hepatic mRNA and protein expression of vascular endothelial growth factor (VEGF) was significantly stimulated. The in vivo growth rate of a subcutaneous VEGF-responsive tumor was also shown to be accelerated by inhalant nitrite exposure. Because the development of KS is extensively linked to VEGF and its receptors, the purported link between inhalant nitrites and KS may be explained mechanistically, at least in part, through the stimulation of VEGF expression by these inhalants.

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Section: Inhalant Nitrite Pharmacokinetics and Footprints Of Biochemimentioning

confidence: 89%

Section: In Vivo Regulation Of Vegf Gene and Protein Expression By Inmentioning

confidence: 99%

Section: In Vivo Regulation Of Vegf Gene and Protein Expression By Inmentioning

confidence: 99%

Section: In Vivo Regulation Of Vegf Gene and Protein Expression By Inmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Inhalant Nitrites on VEGF Expression: A Feasible Link to Kaposi's Sarcoma?

Fung

Tran

2006

Jrnl Neuroimmune Pharm

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“…Recently, animal studies confirmed that dietary acrylamide (a substance generated when food is fried) is mutagenic in mouse lungs [ 22 ]. Nitrite, a potential carcinogen in preserved food, might facilitate the process of lung cancer development; a high serum nitrite level might have a negative effect on the survival of lung cancer patients [ 23 – 25 ]. Consistent epidemiologic evidence has shown that the habit of consuming fresh fruits and vegetables has a preventive effect on lung cancer [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Tse

et al. 2017

Chin J Cancer

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BackgroundAlcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence. However, the effects of these habits on lung cancer prognosis have been studied rarely. The purpose of this study was to address these gaps in knowledge.MethodsWe studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer. Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol, fresh fruits or vegetables, meat, and fried or preserved food.ResultsCompared with never drinkers, men who drank alcohol 1–3 days per week had a more favorable lung cancer prognosis (hazard ratio [HR]: 0.82, 95% confidence interval [CI] 0.68–0.97); however, this survival advantage was not significant in men who drank alcohol more frequently (HR: 0.91, 95% CI 0.73–1.14). Compared with men who consumed preserved or fried food only occasionally, men who consumed these foods frequently had a higher risk of lung cancer mortality (HR: 1.20, 95% CI 1.00–1.42).ConclusionsOccasional consumption of alcohol was a favorable survival factor for Chinese men with lung cancer. However, this survival benefit did not exist for frequent drinkers of alcohol. Chinese men with lung cancer who were frequent consumers of fried or preserved food had a worse prognosis than those who consumed these foods only occasionally.

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Nitric oxide-deficiency regulates hepatic heme oxygenase-1

et al. 2008

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Effects of repeated in vivo inhalant nitrite exposure on gene expression in mouse liver and lungs

Cited by 5 publications

References 44 publications

Effects of Inhalant Nitrites on VEGF Expression: A Feasible Link to Kaposi's Sarcoma?

Effects of Inhalant Nitrites on VEGF Expression: A Feasible Link to Kaposi's Sarcoma?

Prognostic value of alcohol consumption and some other dietary habits for survival in a cohort of Chinese men with lung cancer

Nitric oxide-deficiency regulates hepatic heme oxygenase-1

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