Effects of reperfusion after acute coronary occlusion on the beating, working heart compared to the arrested heart treated locally and globally with cardioplegia

Franco, Kenneth L.; Uretzky, Gideon; Paolini, Domenic; Milton, Gayle; Cohn, Lawrence H.

doi:10.1016/s0022-5223(19)37358-1

Cited by 19 publications

(1 citation statement)

References 21 publications

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“…These 26 studies evaluated a total of 488 animals, including 265 subjects assisted with either surgical or percutaneous LVAD. Types of LVAD included trans-valvular pumps in 13 studies (Impella in nine studies [10,[16][17][18][19][20][21][22][23]; Hemopump in four studies [24][25][26][27]); LV-distal arterial bypass in four studies (2 LV-femoral artery [28,29]; 1 LV-carotid artery [30]; and 1 LV-descending aorta [31]), left atrial-femoral artery bypass in five studies [29,[32][33][34] (including one TandemHeart study [35]), left atrial-ascending aorta bypass in one study [36], and right atrial-femoral/subclavian artery bypass in six studies [17,32,37] (3 studies with LV vent [38][39][40]) (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis

Miyashita

Kariya

Yamada

et al. 2020

J. of Cardiovasc. Trans. Res.

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We conducted a meta-analysis of preclinical studies that tested left ventricular assist device (LVAD) therapy for reducing myocardial infarct size in experimental acute myocardial infarction (AMI). Twenty-six articles were included with a total of 488 experimental animal subjects. The meta-analysis showed that infarct size was significantly decreased by LVAD support compared to control animals (SDM, − 2.19; 95% CI, − 2.70 to − 1.69; P < 0.001). The meta-regression analysis demonstrated a high degree of heterogeneity associated with time from coronary artery occlusion to LVAD support, which correlated positively with infarct size. Subgroup analysis suggested smaller infarct size in LVAD therapies that withdrew blood from left heart than those from right heart. The proportion of left ventricular support relative to total cardiac output was positively correlated with infarct size reduction in Impella studies. Thus, early initiation of LVAD after ischemia and effective left ventricular venting may be important factors to reduce infarct size in AMI.

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