Effects of Reproductive Status, Ovariectomy and Sex Steroid Administration on Estrogen and Progesterone Receptors in the Uterus of Camel

Homeida, A.M.; Al-Eknah, M.M.; Althnaian, Thnaian A.; Alhaider, Abdulrahman; Al-bokhada, I.F.; Almubarak, A.I.

doi:10.3923/rjpharm.2010.5.8

Cited by 2 publications

(1 citation statement)

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“…In contrast, immunohistochemical positive staining of PR was greatly reduced in both the endometrium and myometrium in uterine tissues from pregnant camels, especially in the latest stage that was examined (approximately 366 days of gestation). Homeida, Al‐Eknah, and Althanian () reported that pronounced epithelial nuclear staining of PRs is found in camel uteri during oestrus and pregnancy; however, their study did not provide histological photomicrographs to support their findings.…”

Section: Discussionmentioning

confidence: 82%

Survey of nuclear progesterone receptor expression in the uterus of the cyclic and pregnant camel (Camelus dromedarius)

Osman

Abbott

Ahmed

2018

Anat Histol Embryol

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Progesterone receptors (PR) are necessary to mediate the biological effects of progesterone and are integral to the regulation of a number of different aspects of reproduction in mammals including ovulation of the oocyte, implantation of the conceptus and maintenance of pregnancy. This study investigated the expression and localization of progesterone receptors in the uterine wall of both pregnant and cyclic (nonpregnant) camels. Uterine tissue samples were collected from healthy animals and processed for routine histological and immunohistochemical staining techniques to reveal nuclear PR. Demonstration of PR was performed by indirect immunohistochemical techniques using monoclonal antibodies raised against human PR. Immunolocalization of PR was more intense in all four endometrial zones (I-IV) as well as the myometrium of non pregnant (cyclic) animals (animals with newly formed corpus luteum). In contrast, PR immunostaining in both the endometrium and the myometrium was greatly reduced in pregnancy, particularly in the latest stage examined (approximately 366 days of gestation). In conclusion, a better understanding of the expression of steroid hormones and their receptors, including progesterone and the PR is critical to improving the reproductive health and pregnancy in the domesticated dromedary camel.

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Section: Discussionmentioning

confidence: 82%