Effects of reserpine and chlorpromazine on rats subjected to experimental stress

Buckley, Joseph P.; Kato, Hitoshi; Kinnard, William J.; Aceto, Mario D.; Estévez, José Manuel Gálligo

doi:10.1007/bf00413221

Cited by 18 publications

(3 citation statements)

References 7 publications

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“…The severity of elevations obtained in this study, although below those reported by Dahl and his co-workers using physiologic hypertensinogenic techniques (15,16), were generally higher than previously reported by other investigators using Pavlovian (3,17) or operant (4,18,19) conditioning procedures. Likewise, the percentage of subjects exhibiting impressive elevations was higher than previously reported (1,20,21).…”

Section: Discussioncontrasting

confidence: 71%

The Effect of Chronic Conflict on the Blood Pressure of Rats with a Genetic Susceptibility to Experimental Hypertension

Friedman

Dahl

1975

Psychosomatic Medicine

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Rats with a genetic susceptibility to experimental hypertension were exposed daily for 13 weeks to a conflict situation that resulted in food deprivation and the application of electric shock. Other subjects were either food deprived, shocked, both food deprived and shocked but without conflict, or not experimentally manipulated (control). Despite weekly fluctuations, a pattern emerged wherein subjects exposed to conflict usually exhibited the highest systolic blood pressures followed in order by subjects exposed to food deprivation and shock without conflict, rats food deprived, rats exposed to shock, and control subjects. Following this 13 week period, some of the rats in each group were allowed a 13 week stress-free-recovery period while the rest of the subjects were treated as before. During the recovery period most subjects' blood pressure returned to control levels. However, there was some indication in a few rats that elevations could persist for extended periods after the aversive treatment had been terminated. There is probably a genetic component involved in the reaction to stress that promotes the development of hypertension, just as there is to other hypertensinogenic stimuli.

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Section: Discussioncontrasting

confidence: 71%

The Effect of Chronic Conflict on the Blood Pressure of Rats with a Genetic Susceptibility to Experimental Hypertension

Friedman

Dahl

1975

Psychosomatic Medicine

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“…Several models have been developed to study the causes of stress-induced hypertension. These models have typically been limited to special strains of rats (1,31), to surgical interventions (3), or to prolonged exposure to behavioral stress (7,15,20,23). The present model uses outbred Sprague-Dawley rats, a strain not known for its sensitivity to stress-induced hypertension.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic response pattern predicts susceptibility to stress-induced elevation in arterial pressure in the rat

Müller

Haines

et al. 2001

American Journal of Physiology-Regulatory, Integrative and Comp

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Cocaine or air jet stress evokes pressor responses due to either a large increase in systemic vascular resistance (vascular responders) or small increases in both cardiac output and vascular resistance (mixed responders) in conscious rats. Repeated cocaine administration results in elevated arterial pressure in vascular responders but not in mixed responders. The present study examined the hypothesis that the pattern of cardiovascular responses to an unconditioned stimulus (UCS; air jet) is related to responses to a conditioned stimulus (CS; tone followed by brief foot shock) in individual rats. Our data demonstrate that presentation of the UCS produced variable cardiac output responses that correlated with responses to the CS (n = 60). We also determined whether individual cardiovascular response patterns to acute stress correlated with predisposition to a sustained stress-induced elevation in arterial pressure. Rats were exposed to three different stressors presented one per day successively for 4 wk and during a poststress period of 3 wk while arterial pressure was recorded periodically. Mean arterial pressure was elevated in all rats during chronic stress but, during the poststress period, remained at significantly higher levels in vascular responders but not mixed responders. Therefore, we conclude that acute behavioral stress to a conditioned stimulus elicits variable hemodynamic responses that predict the predisposition to a sustained stress-induced elevation in arterial pressure.

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“…Rubenson [22] recently reported that immobilized animals showed an accelerated disappearance of heart and kidney NE. Buckley et al [2] using a combination of several stressors showed that reser pine potentiated the lethal effect of these stressors.…”

Section: Discussionmentioning

confidence: 99%

Central vs. Peripheral Catecholamines in Rats During Adaptation to Chronic Restraint Stress

Blaszkowski¹,

DeFeo²,

Guarino³

1970

Pharmacology

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Effects of reserpine and chlorpromazine on rats subjected to experimental stress

Cited by 18 publications

References 7 publications

The Effect of Chronic Conflict on the Blood Pressure of Rats with a Genetic Susceptibility to Experimental Hypertension

The Effect of Chronic Conflict on the Blood Pressure of Rats with a Genetic Susceptibility to Experimental Hypertension

Hemodynamic response pattern predicts susceptibility to stress-induced elevation in arterial pressure in the rat

Central vs. Peripheral Catecholamines in Rats During Adaptation to Chronic Restraint Stress

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