Effects of reserpine, guanethidine and methyldopa on cardiac output and its distribution

Kisin, I. E.; Yuzhakov, S. V.

doi:10.1016/0014-2999(76)90227-2

Cited by 13 publications

(1 citation statement)

References 12 publications

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“…Twenty four h after reserpinization, the arterial blood pressure of the rats was lower than in the non-reserpinized animals confirming previous reports (Kisin & Yuzhakov, 1976). The pressor effect of L-NAME (30mgkg-1) tended to be higher (43mmHg) than in non-treated rats (25mmHg).…”

Section: Discussionsupporting

confidence: 87%

Influence of N^G‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat

Lefebvre

Hasrat

Gobert

1992

British J Pharmacology

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1 The influence of the nitric oxide (NO) biosynthesis inhibitor N0-nitro-L-arginine methyl ester (L-NAME) on the gastric relaxation induced by peripheral vagal stimulation was investigated in the anaesthetized rat.2 Peripheral vagal stimulation (10 Hz, 10 V, 1 ms for 20 s) induced a reproducible biphasic response: a short-lasting increase followed by a more pronounced decrease in intragastric pressure. This response also occurred in reserpinized animals (5mg kg-, i.p., 24 h before the experiment) while atropine (1 mg kg1, i.v.) abolished the initial increase in intragastric pressure. 3 L-NAME (1-30mg kg-',i.v.) induced an increase in arterial blood pressure. L-NAME (1 mg kg-i.v.) had no influence on the vagally induced gastric response while L-NAME (10 and 30mgkg-' i.v.) significantly changed it: the initial increase in intragastric pressure was enhanced while the decrease in intragastric pressure was reduced or abolished. N0-nitro-L-arginine (L-NNA, l0 mg kg-%, i.v.) had the same effect.4 An i.v. infusion of phenylephrine (10pgkg-lmin-1) inducing a pressor response similar to that produced by L-NAME (30mgkg-1, i.v.) did not influence the vagal gastric response. Infusion of L-arginine (300mgkg-' bolus, then lOOmgkg-lh-') starting 30min beforehand, reduced the pressor effect and prevented the influence of L-NAME (lOmgkg-, i.v.) on the vagal gastric response. After injection of both atropine (lmgkg-', i.v.) and L-NAME (30mgkg-', i.v.), the vagally induced decrease in intragastric pressure was similar to that obtained under control conditions. 5 These results are consistent with NO being released and inducing gastric relaxation during peripheral vagal stimulation. In addition to NO, another inhibitory non-adrenergic non-cholinergic neurotransmitter is released.

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Section: Discussionsupporting

confidence: 87%

Influence of N^G‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat

Lefebvre

Hasrat

Gobert

1992

British J Pharmacology

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Effects on the General Hemodynamics and Peripheral Circulation

Vapaatalo¹,

Säynävälammi²

1980

Adrenergic Activators and Inhibitors

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Toxic Effects of Adrenergic Nerve-End Inhibitors, Neural-Transmitter Depleting Agents and False Transmitters

Juul¹

1981

Adrenergic Activators and Inhibitors

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Effects of reserpine, guanethidine and methyldopa on cardiac output and its distribution

Cited by 13 publications

References 12 publications

Influence of N^G‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat

Influence of N^G‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat

Effects on the General Hemodynamics and Peripheral Circulation

Toxic Effects of Adrenergic Nerve-End Inhibitors, Neural-Transmitter Depleting Agents and False Transmitters

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Effects of reserpine, guanethidine and methyldopa on cardiac output and its distribution

Cited by 13 publications

References 12 publications

Influence of NG‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat

Influence of NG‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat

Effects on the General Hemodynamics and Peripheral Circulation

Toxic Effects of Adrenergic Nerve-End Inhibitors, Neural-Transmitter Depleting Agents and False Transmitters

Contact Info

Product

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Influence of N^G‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat

Influence of N^G‐nitro‐l‐arginine methyl ester on vagally induced gastric relaxation in the anaesthetized rat