Effects of resveratrol on bone metabolism and bone turnover related indexes in ovariectomized osteoporosis rats

Zhang, Yujin; Lin, Dong‐Tsamn; Fan, Jiubo; Ya-zhi, Zhang

doi:10.14715/cmb/2020.66.5.17

Cited by 10 publications

(12 citation statements)

References 32 publications

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“…Analysis of 45 studies [ 17 , 19 , 23 – 26 , 28 – 32 , 34 , 36 , 39 , 40 ] showed that, compared with the control group, the Res group had a markedly greater BMD ( n = 587; SMD, 1.59; 95% confidence interval (CI), 1.22 to 1.96; I 2 = 60%, P < 0.00001). Due to the high heterogeneity, we analyzed the BMD subgroups according to the methods of modeling, test methods and test positions (Fig.…”

Section: Effectivenessmentioning

confidence: 99%

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

An,

Luo,

et al. 2024

J Orthop Surg Res

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Background There is still a lack of sufficient evidence-based medical data on the effect of resveratrol (Res) on primary osteoporosis (OP). This meta-analysis aimed to comprehensively evaluate the role of Res in animal models of primary OP. Methods The PubMed, Cochrane Library, Web of Science and Embase databases were searched up to August 2023. The risk of bias was assessed by the SYRCLE RoB tool. Random- or fixed-effects models were used to determine the 90% confidence interval (CI) or standardized mean difference (SMD). Statistical analysis was performed with RevMan 5.4 and Stata 14.0. Results A total of 24 studies containing 714 individuals were included. Compared with those in the control group, the bone mineral density (BMD) (P < 0.00001), bone volume/total volume (BV/TV) (P < 0.001), trabecular thickness (Tb.Th) (P < 0.00001), and trabecular number (Tb.N) (P < 0.00001) were markedly greater, and the trabecular separation (Tb.Sp) (P < 0.00001) was significantly greater. Compared with the control group, the Res group also exhibited marked decreases in alkaline phosphatase (ALP) (P < 0.05), tartrate-resistant acid phosphatase 5b (TRAP5b) (P < 0.01), and type I collagen strong carboxyl peptide (CTX-1) (P < 0.00001) and a marked increase in osteoprotegerin (OPG) (P < 0.00001). Conclusion In summary, we concluded that Res can markedly increase BMD, improve morphometric indices of trabecular microstructure and serum bone turnover markers (BTMs), and exert a protective effect in animal models of primary osteoporosis. This study can supply experimental reference for Res in primary osteoporosis treatment.

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Section: Effectivenessmentioning

confidence: 99%

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

An,

Luo,

et al. 2024

J Orthop Surg Res

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“…And there was a negative correlation between high bone turnover rate and BMD. Several studies have reported that not only did the OVX osteoporosis rats present with osteoporosis but the biochemical markers of their bone turnover also exhibited a high turnover rate (12)(13)(14)(15), with biasing to bone loss in bone remodeling (16). The results of the present study showed that both the TRACP 5b and OCN of the OVX group rats were significantly increased, indicating that estrogen deficiency resulted in high bone turnover, destroying the structure of the bone trabeculae and reducing their number and thickness, thereby reducing bone strength and bone density and, eventually, leading to the occurrence of osteoporosis.…”

Section: Effect Of Moderate-intensity Treadmill Exercise On the Bone ...mentioning

confidence: 99%

Postmenopausal osteoporosis: Effect of moderate-intensity treadmill exercise on bone proteomics in ovariectomized rats

Yang

Gao

2023

Front. Surg.

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ObjectivesThis study aimed to identify the key proteins in the bone mass of ovariectomized (OVX) rats after a period of regular moderate-intensity treadmill exercise and to investigate their effects using tag mass spectrometry and quantitative proteomics with a view to improving the understanding and treatment of postmenopausal osteoporosis.MethodsSixty three-month-old female Sprague-Dawley tats of specific-pathogen-free grade were randomly and equally divided into a sham operation group, ovariectomized group (OVX) and ovariectomized combined exercise (OVX + EX) group, and the latter took moderate-intensity treadmill exercise for 17 weeks. After this period of time, body composition and bone density were measured using dual-energy x-ray absorptiometry, and serum bone metabolism indicators were measured using an enzyme immunoassay. In addition, the bone microstructure was examined using micro-computed tomography and scanning of the femur, and femur proteins were subject to proteomic analysis.ResultsCompared with the rats in the OVX group, the bone metabolism indicators in the OVX + EX group decreased significantly, femur bone density increased significantly, the number of the trabeculae increased, and continuity was higher. In the OVX + EX group, 17 proteins were significantly upregulated and 33 significantly downregulated. The main gene ontology and signaling pathways enriched by the proteins were identified as the tumor necrosis factor-mediated signaling pathways. The protein-protein interaction network identified the key proteins, and the correlation analysis of these proteins and the bone parameters found histone deacetylase 8(HDAC8) and leucine-rich transmembrane and O-methyltransferase domain containing (LRTOMT) and trimethylguanosine synthase 1(TGS1) and ankyrin repeat domain 46(ANKRD46) to be the key targets of exercise in relation to postmenopausal osteoporosis.ConclusionModerate-intensity treadmill exercise significantly improved the bone mass of OVX rats, and differentially expressed proteins, such as HDAC8 and LRTOMT and TGS1 and ANKRD46, could be the target of moderate-intensity treadmill exercise.

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“…Besides such effects, it also exerts favorable effects on osteoporosis in ovariectomized rats and mice, as summarized in Table 1 . Several studies have demonstrated that the oral administration of resveratrol in ovariectomized rodents mitigates estrogen deficiency-induced bone loss [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ], and with respect to its anti-osteoporotic mechanisms, it has been demonstrated that resveratrol not only promotes osteoblast differentiation but also suppresses osteoclast differentiation [ 22 , 24 , 28 ]. It has been proposed that microRNAs (miRNAs/miRs) play a pivotal role in estrogen deficiency-induced osteoporosis prevention.…”

Section: Resveratrolmentioning

confidence: 99%

Anti-Osteoporotic Mechanisms of Polyphenols Elucidated Based on In Vivo Studies Using Ovariectomized Animals

et al. 2022

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Polyphenols are widely known for their antioxidant activity, i.e., they have the ability to suppress oxidative stress, and this behavior is mediated by the autoxidation of their phenolic hydroxyl groups. Postmenopausal osteoporosis is a common health problem that is associated with estrogen deficiency. Since oxidative stress is thought to play a key role in the onset and progression of osteoporosis, it is expected that polyphenols can serve as a safe and suitable treatment in this regard. Therefore, in this review, we aimed to elucidate the anti-osteoporotic mechanisms of polyphenols reported by in vivo studies involving the use of ovariectomized animals. We categorized the polyphenols as resveratrol, purified polyphenols other than resveratrol, or polyphenol-rich substances or extracts. Literature data indicated that resveratrol activates sirtuin 1, and thereafter, suppresses osteoclastogenic pathways, such as the receptor activator of the nuclear factor kappa B (RANK) ligand (RANKL) pathway, and promotes osteoblastogenic pathways, such as the wingless-related MMTV integration site pathway. Further, we noted that purified polyphenols and polyphenol-rich substances or extracts exert anti-inflammatory and/or antioxidative effects, which inhibit RANKL/RANK binding via the NF-κB pathway, resulting in the suppression of osteoclastogenesis. In conclusion, antioxidative and anti-inflammatory polyphenols, including resveratrol, can be safe and effective for the treatment of postmenopausal osteoporosis based on their ability to regulate the imbalance between bone formation and resorption.

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Effects of resveratrol on bone metabolism and bone turnover related indexes in ovariectomized osteoporosis rats

Cited by 10 publications

References 32 publications

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

Postmenopausal osteoporosis: Effect of moderate-intensity treadmill exercise on bone proteomics in ovariectomized rats

Anti-Osteoporotic Mechanisms of Polyphenols Elucidated Based on In Vivo Studies Using Ovariectomized Animals

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