Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats

Protective effects of dietary resveratrol supplementation against oxidative stress in diquat-challenged piglets

“…The serum activity of GSH-Px was also increased in piglets fed with 90 mg/kg RES diet than those piglets fed with the NC diet at 7 d post-injection. These results are analogous to those reported previously in sows (Meng et al 2018), broilers (He et al 2019), and rats (Cheng et al 2019). The observed rise in antioxidant indices induced by RES supplementation may be explained as an important reason for the improvement in growth performance of piglets challenged by diquat.…”

“…In contrast, IL-4 is thought to suppress or decrease the inflammatory responses by inhibiting the secretion of pro-inflammatory cytokines, such as IL-1b, IL-6, and TNF-a (Rubinstein and Rubinstein 1990). Previous studies have demonstrated that RES supplementation, under stress conditions, displays beneficial activity against inflammatory responses in piglets (Gan et al 2019), rats (Cheng et al 2019) and lambs (Liang et al 2019) by modulating the production of cytokines. In the present study, injecting diquat significantly increased the levels of serum IL-1b, IL-6, and TNF-a, whereas decreased the levels of serum IL-4 in piglets.…”

“…Liang et al (2019) demonstrated that RES inhibited the production and secretion of cortisol in LPS challenged lambs. Studies in rodents also illustrated that RES alleviated heat stress by decreasing serum cortisol level (Cheng et al 2019), which suggests that RES was not species specific in its functions and could be most likely to be applied to all animals. Immunoglobulin, including IgG, IgM and IgA, are important components of the of the body's immune system in animals.…”

Anti-Inflammatory Action and Mechanisms of Resveratrol

“…As a known marker of oxidative DNA damage, the levels of 8-oxo-7,8-dihydroxy-29-deoxyguanosine decrease with the addition of resveratrol in vivo [135]. Moreover, resveratrol is able to alleviate intestinal injury and dysfunctions though improving oxidative status and inhibiting inflammatory responses in rats under heat stress [136].…”

Effects of dietary chitosan oligosaccharides on oxidative stress and inflammation response in liver and spleen of yellow-feather broilers exposed to high ambient temperature

“…Previous studies indicated that heat stress had negative effects on performance, health, and wellbeings of broilers (Lara and Rostagno 2013). Moreover, heat stress resulted in oxidative stress (Ando et al 1997), which, in turn, inducing adverse effects on DNA, protein, and lipids, and finally led to tissue damage, inflammatory disease, and some other diseases (Zhang et al 2018;Cheng et al 2019a;Cheng et al 2019b). Heat stress also induced inflammation response (Jang et al 2014;Ohtsu et al 2015;Wang et al 2018).…”