Effects of rhein lysinate on D-galactose-induced aging mice

Zhen, Yong‐Su; Lin, Yajun; Li, Kai‑Ji; Zhang, Guangling; Zhao, Yufang; Wang, Mei‐Mei; Jing-bo, Wei; Wei, Jie; Hu, Gang

doi:10.3892/etm.2015.2858

Cited by 34 publications

(20 citation statements)

References 47 publications

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“…The free radical theory poses that reactive oxygen species (ROS)-induced oxidative damage plays a requisite part in the pathophysiology of ageing 2 , 3 . Abundant evidence suggests that oxygen-derived free radicals are closely correlated to signal recognition, protein expression, and immune response.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

Chen

Zhou

2018

Sci Rep

145

104

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Accumulating evidence has suggested that oxidative stress and apoptosis are involved in the ageing process. D-galactose (gal) has been reported to cause symptoms of ageing in rats, accompanied by liver and brain injuries. Our study aimed to investigate the potential antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid and to explore how these effects act on rats in a D-gal-induced ageing model. Ageing was induced by subcutaneous injection of D-gal (100 mg/kg/d for 8 weeks). Ellagic acid was simultaneously administered to the D-gal-induced ageing rats once daily by intragastric gavage. Finally, the mental condition, body weight, organ index, levels of inflammatory cytokines, antioxidative enzymes, and liver function, as well as the expression of pro- and anti-apoptotic proteins, were monitored. Our results showed that ellagic acid could improve the mental condition, body weight, organ index and significantly decrease the levels of inflammatory cytokines, normalize the activities of antioxidative enzymes, and modulate the expression of apoptotic protein in ageing rats. In conclusion, the results of this study illustrate that ellagic acid was suitable for the treatment of some ageing-associated problems, such as oxidative stress, and had beneficial effects for age-associated diseases.

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Section: Introductionmentioning

confidence: 99%

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

Chen

Zhou

2018

Sci Rep

145

104

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“…In addition, the endogenous antioxidant enzyme system, mainly including SOD (an enzyme devoted to scavenge superoxide anion radicals and reduce the production of lipid peroxidation), CAT (an enzyme dedicated to scavenge H 2 O 2 to protect peroxidation of cell wall lipid and lipoproteins), and GSH-Px (an enzyme concentrated on catalyzing GSH into GSSG and stimulating the toxic peroxide reduction into non-toxic hydroxyl compounds), is an important defense system against free radical damage in the body, the main function of which is to maintain the homeostasis of ROS in the internal environment and to remove excessively high levels of ROS [ 4 , 5 , 32 , 33 ]. Numerous evidences exhibit that the excessive production of ROS in biological systems can cause oxidative damage to tissues, impair membrane functions, affect cellular metabolism, and passivate proteins and enzymes, especially in the organs with fast metabolic processes like the liver and kidney [ 34 , 35 , 36 ]. Consistent with these studies, we found that repeated d -gal-injection induced an observable decrease in the activities of these key antioxidant enzymes (SOD, CAT, and GSH-Px), and markedly aggravated lipid peroxidation, manifested as the accumulation of MDA, indicating that oxidative damages occurred in mice liver and kidney.…”

Section: Discussionmentioning

confidence: 99%

Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice

Kong

et al. 2018

Marine Drugs

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Chitosan oligosaccharide (COS), a natural polysaccharide with good antioxidant and anti-inflammatory properties, is the depolymerized product of chitosan possessing various biological activities. The present study was designed to investigate the possible anti-aging effect of COS on the aging model mouse induced by d-galactose (d-gal) and explore the underlying mechanism. In the experiment, 48 male Kunming mice (KM mice) were randomly divided into the normal group, model group, positive group, and low-medium-high dose polysaccharide groups (300, 600, 1200 mg/kg/day). The results showed that COS, by intragastric gavage after subcutaneous injection of d-gal (250 mg/kg/day) into the neck of mice consecutively for eight weeks, gradually recovered the body weight, the activity of daily living, and organ indices of mice, as well as effectively ameliorated the histological deterioration of the liver and kidney in mice triggered by d-gal. To be specific, COS obviously improved the activities of antioxidant enzymes in liver and kidney of KM mice, including catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), as well as decreased malondialdehyde (MDA) levels when compared with those in model group mice. Furthermore, COS not only elevated the diminished levels of serum immunoglobulin G (IgG) and IgM induced by d-gal, but also significantly inhibited the d-gal-caused upregulation of serum alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), uric acid (UA) and creatinine (CREA) levels as compared with those of mice in the model group. These results demonstrate that COS has an obvious anti-aging activity in d-gal-induced subacute aging mice, the mechanism of which, to some extent, is associated with enhancing the antioxidant defenses, reducing oxidative stress, and improving the immune function of aging model mice.

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“…Sirt1 may increase organismal longevity by tipping FOXO-dependent responses away from apoptosis and toward stress resistance [54]. Studies have found that Sirt1 expressions in the liver, kidney were decreased in D-gal-treated mice [55]. In addition, Glb1, which coding β-galactosidase, has been reported to increase during the replicative senescence of fibroblast cultures and has been used widely as a marker of cellular senescence in vivo and in vitro [56].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice

Ota

Yang

et al. 2018

Endocr J

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Oxidative stress caused free radical and mitochondrial damage plays a critical role in the progression of aging and age-related damage at the cellular and tissue levels. Antioxidant supplementation has received growing attention and the effects of antioxidant on aging are increasingly assessed in both animal and human studies. However, additional and more promising treatments that contribute to the expansion of anti-aging therapies are needed. Astaxanthin, a super antioxidant carotenoid and free radical scavenger, inhibits lipid peroxidation more potently than vitamin E. In the present study, we investigated the preventative effects of astaxanthin on aging using an accelerated aging model: mice chronically treated with a combination of D-galactose and jet lag. After 6 weeks of treatment, astaxanthin administration tended to protect the liver weight loss in aged mice. It is probably by upregulating the mRNA expression of galactose-1-phosphate uridyltransferase, which contribute to the enhancement of D-galactose metabolism. Astaxanthin supplementation also improved muscle endurance of aged mice in a swimming test. These results were associated with reduced oxidative stress in serum and increased anti-oxidative enzymes activities and mRNA expression in vivo. Moreover, astaxanthin reversed the dysregulation of aging-related gene expression caused by the combination of D-galactose and jet lag in the liver and kidney of mice. In conclusion, astaxanthin prevents liver weight loss, ameliorates locomotive muscular function, exerts significant anti-aging effects by reducing oxidative stress and improving the expression of age-related genes in D-galactose and jet lag-induced aging model.

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Effects of rhein lysinate on D-galactose-induced aging mice

Cited by 34 publications

References 47 publications

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice

Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice

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