Effects of rhizome of Atractylodes koreana (Nakai) Kitam on intestinal flora and metabolites in rats with rheumatoid arthritis

Pang, Jian; Ma, Shanpeng; Xu, Xiaoying; Zhang, Beixue; Cai, Qian

doi:10.1016/j.jep.2021.114026

Cited by 27 publications

(15 citation statements)

References 15 publications

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“…This difference was consistent with the result that cinnamaldehyde microcapsules increased butyric-producing bacteria. A similar finding was found in the study of Atractylodeskoreana (Nakai) Kitam , which improved the intestinal butyric acid level in rats with rheumatoid arthritis by regulating the intestinal flora that is positively or negatively correlated with butyric acid production ( Pang, Ma, Xu, Zhang, & Cai, 2021 ).…”

Section: Resultssupporting

confidence: 80%

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Xiao

Zhang

et al. 2022

Food Chemistry: X

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Section: Resultssupporting

confidence: 80%

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Xiao

Zhang

et al. 2022

Food Chemistry: X

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“…Studies have shown that the expression of IL-6 and hs-CRP is upregulated after ischemic stroke, which are associated with intestinal flora disorders ( Chen et al., 2021 ; Pang et al., 2021 ; Wang et al., 2022 ). An imbalance in intestinal flora can lead to increased phenylalanine and isoleucine in the peripheral accumulation, which can promote inflammation ( Wang et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive evaluation of the mechanism of Gastrodia elata Blume in ameliorating cerebral ischemia–reperfusion injury based on integrating fecal metabonomics and 16S rDNA sequencing

Ding

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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Gastrodia elata Blume was used to treat stroke and headaches caused by “Feng” for thousands of years. The present study has shown a significant effect of G. elata Blume in improving cerebral ischemia–reperfusion injury (CIRI). However, the mechanism of G. elata Blume in improving CIRI by regulating the intestinal flora has not been reported until now. This research aimed to comprehensively evaluate the mechanism of G. elata Blume in CIRI based on fecal metabolomics and 16S rDNA sequencing. The rat model with CIRI was created based on the Zea Longa method. Enzyme-linked immunosorbent assay (ELISA) was used to monitor the inflammatory factors in rat serum. Damages of brain tissues were observed using hematoxylin and eosin (H&E) staining. Cerebral infarction was observed by 2,3,5-triphenyltetrazolium chloride (TTC) staining. The balance of intestinal flora in cecal contents of rats was evaluated by high-throughput sequencing. Changes of metabolites in the intestinal flora were evaluated by fecal metabolomics through Ultra high performance liquid chromatography-orbitrap exploris-mass spectrometer (UHPLC-OE-MS). The area of brain necrosis, cerebral infarction volume, and the contents of inflammatory factors in CIRI rats can be effectively reduced after oral administration of G. elata Blume. CIRI can cause disturbances in the intestinal flora and its associated metabolites. G. elata Blume can significantly regulate the composition of the intestinal microflora. It reversed CIRI-induced changes in the levels of multiple intestinal bacteria, including Prevotellaceae, Coriobacteriaceae; Prevotella, Gamma proteobacteria unclassified, Barnesiella, Escherichia, Shigella; uncultured Shigella sp., Flavonifractor sp., Escherichia sp. enrichment culture clone NBAR004, Veillonella sp. R-32, and Lactobacillus intestinalis. The levels of metabolites in cecal contents were disturbed in rats with CIRI, including amino acid, purine, and sphingolipid metabolism. The changes in the level of biomarkers in amino acid metabolism induced by CIRI were significantly reversed after treatment with G. elata Blume. Correlation studies show that Prevotellaceae was significantly positively correlated with interleukin (IL)-6, and L. intestinalis and L-phenylalanine were negatively interrelated to IL-1β. Beta-glycerophosphoric acid was significantly negatively interrelated to high-sensitivity C-reactive protein (hs-CRP). There were significantly negative correlations between L-phenylalanine and L. intestinalis, beta-glycerophosphoric acid and Prevotellaceae. G. elata Blume protected against CIRI, which may be related to improved intestinal microflora composition and metabolism, resulting in decreased inflammation.

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“…To date, a large number of studies have confirmed that RA can cause disturbance of the intestinal flora and SCFAs, while regulating the intestinal flora can restore SCFA levels, protect the intestinal barrier, regulate the immune balance, attenuate the inflammatory response in RA ( 129 , 140 ), and inhibit bone destruction. These results illustrate that SCFAs play an essential role in the gut–joint axis.…”

Section: Role Of Short-chain Fatty Acids In the Gut–joint Axismentioning

confidence: 99%

The bridge of the gut–joint axis: Gut microbial metabolites in rheumatoid arthritis

Wang

et al. 2022

Front. Immunol.

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction, synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic effects on gut homeostasis. It may trigger the host’s innate immune system and activate the “gut–joint axis”, which exacerbates the RA. However, although the importance of the gut microbiota in the development and progression of RA is widely recognized, the mechanisms regulating the interactions between the gut microbiota and the host immune system remain incompletely defined. In this review, we discuss the role of gut microbiota-derived biological mediators, such as short-chain fatty acids, bile acids, and tryptophan metabolites, in maintaining intestinal barrier integrity, immune balance and bone destruction in RA patients as the bridge of the gut–joint axis.

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Effects of rhizome of Atractylodes koreana (Nakai) Kitam on intestinal flora and metabolites in rats with rheumatoid arthritis

Cited by 27 publications

References 15 publications

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Comprehensive evaluation of the mechanism of Gastrodia elata Blume in ameliorating cerebral ischemia–reperfusion injury based on integrating fecal metabonomics and 16S rDNA sequencing

The bridge of the gut–joint axis: Gut microbial metabolites in rheumatoid arthritis

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