Effects of rilmenidine on 24-h rhythmicity of blood pressure and spontaneous baroreflex sensitivity in essential hypertensive subjects

Finta, Ervin; Laude, Dominique; Alföldi, Sándor; Farsang, Csaba; Jl, Elghozi

doi:10.1097/01.hjh.0000239298.63377.db

Cited by 12 publications

(10 citation statements)

References 22 publications

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“…Moreover, rilmenidine infusion also resulted in a reduction in night-time MAP power in the midfrequency range only in BPH/2J mice, which indicates a reduction in SNS activity. Rilmenidine treatment also increased baroreflex gain exclusively in BPH/2J mice, which is consistent with the effect of rilmenidine in mild essential hypertensive patients [44]. The reduction in MF-MAP power to similar levels observed in normotensive BPN/3J mice indicates that chronic rilmenidine treatment does appear to effectively reduce vasomotor SNS activity.…”

Section: Discussionsupporting

confidence: 61%

Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice

Jackson

Palma‐Rigo

Nguyen‐Huu

et al. 2014

Journal of Hypertension

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Section: Discussionsupporting

confidence: 61%

Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice

Jackson

Palma‐Rigo

Nguyen‐Huu

et al. 2014

Journal of Hypertension

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“…By contrast we did not observe any change in gain either acutely (Godwin et al, 1998) or chronically (current study) in conscious rabbits. A 4 week treatment of 8 mildly hypertensive patients demonstrated a small increase in baroreflex sensitivity after 4 weeks of rilmenidine but this study was an open label trial with no randomisation, crossover or placebo thus making interpretation difficult (Finta et al, 2006). …”

Section: Discussionmentioning

confidence: 99%

Comparison in Conscious Rabbits of the Baroreceptor-Heart Rate Reflex Effects of Chronic Treatment with Rilmenidine, Moxonidine, and Clonidine

et al. 2016

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We investigated the effects of chronic subcutaneous treatment with centrally-acting antihypertensive agents moxonidine, rilmenidine, and clonidine on the baroreflex control of heart rate (HR) in conscious normotensive rabbits over 3 weeks. Infusions of phenylephrine and nitroprusside were performed at week 0 and at weeks 1 and 3 of treatment to determine mean arterial pressure (MAP)-HR baroreflex relationships. A second curve was performed after intravenous methscopolamine to determine the sympathetic baroreflex relationship. The vagal component of the reflex was determined by subtracting the sympathetic curve from the intact curve. Clonidine and moxonidine (both 1 mg/kg/day), and rilmenidine (5 mg/kg/day), reduced MAP by 13 ± 3, 15 ± 2, and 13 ± 2 mmHg, respectively, but had no effect on HR over the 3-week treatment period. Whilst all three antihypertensive agents shifted baroreflex curves to the left, parallel to the degree of hypotension, moxonidine and rilmenidine decreased the vagal contribution to the baroreflex by decreasing the HR range of the reflex but moxonidine also increased sympathetic baroreflex range and sensitivity. By contrast clonidine had little chronic effect on the cardiac baroreflex. The present study shows that second generation agents moxonidine and rilmenidine but not first generation agent clonidine chronically shift the balance of baroreflex control of HR toward greater sympathetic and lesser vagal influences. These changes if translated to hypertensive subjects, may not be particularly helpful in view of the already reduced vagal contribution in hypertension.

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“…BRS can be quantified from the slopes of the regression lines obtained between changes in PI and SBP. With the ability for continuous longterm monitoring of finger SBP, the sequence technique of BRS estimation has been employed in clinical studies of baroreceptor function in a range of cardiovascular conditions [6], [11]- [13]. However, although peripheral locations (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…The ability for continuous monitoring of arterial pressure [5] enabled investigations assessing blood pressure variability in short (beat-to beat) and long (minutes, hours) time scales [6], [7]. In combination with beat-to-beat changes in pulse interval (PI), techniques were developed that facilitated the assessment of baroreceptor function, specifically the cardiovagal arc of the baroreceptor control system [8], [9].…”

Section: Introductionmentioning

confidence: 99%

Assessment of baroreflex sensitivity by continuous noninvasive monitoring of peripheral and central aortic pressure

Kouchaki

Butlin

Qasem³

et al. 2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Noninvasive assessment of baroreceptor sensitivity (BRS) facilitates clinical investigation of autonomic function. The spontaneous sequence method estimates BRS using the continuous measurement of arterial pressure in the finger. Since the baroreceptors are centrally located (aortic arch, carotid arteries), this study assessed the use of a continuous aortic pressure signal derived from the peripheral pressure pulse to compute the BRS from changes in systolic pressure (SBP) and pulse interval (PI). BRS computed from central aortic (cBRS) and peripheral pressure (pBRS) was calculated in 12 healthy subjects (25-62 years, 7 females). The difference between pBRS and cBRS was calculated for four levels of pulse lags between changes in SBP and PI. For each lag and for the pooled data for all lags, cBRS was significantly correlated with pBRS (r(2)=0.82). The within subject difference ranged from -41.2% to 59.2%. This difference was not related to age, gender of hemodynamic parameters (systolic or diastolic pressure, heart rate, aortic pulse wave velocity). However 18.2% of the variance was due to the difference in the number of spontaneous pulse sequences used to determine values of cBRS and pBRS. The differences between pBRS and cBRS are in the range of values of BRS as those found, in other studies, to discriminate between patient groups with different levels of autonomic function. Findings of this study suggest that, given the heart rate dependent amplification of the arterial pressure pulse between the central aorta and the peripheral limbs, BRS determined from central aortic pressure derived from the peripheral pulse may provide an improved method for noninvasive assessment of baroreceptor function.

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Effects of rilmenidine on 24-h rhythmicity of blood pressure and spontaneous baroreflex sensitivity in essential hypertensive subjects

Abstract: Rilmenidine may differentially affect the baroreflex-dependent (phasic or reflex) and the baroreflex-independent (tonic) autonomic outflow. The 24-h approach reinforced this concept, since indexes of BRS were increased throughout the 24-h period while BP was reduced during the daytime.

Cited by 12 publications

References 22 publications

Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice

Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice

Comparison in Conscious Rabbits of the Baroreceptor-Heart Rate Reflex Effects of Chronic Treatment with Rilmenidine, Moxonidine, and Clonidine

Assessment of baroreflex sensitivity by continuous noninvasive monitoring of peripheral and central aortic pressure

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