2017
DOI: 10.1042/bsr20170342
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Effects of RNA interference-mediated gene silencing of VEGF on the ultrafiltration failure in a rat model of peritoneal dialysis

Abstract: We investigated the effects of RNAi-mediated gene silencing of vascular endothelial growth factor (VEGF) on ultrafiltration failure (UFF) in rats with peritoneal dialysis (PD). Sprague–Dawley (SD) male rats were classified into normal, sham operation, and uremic model groups. Uremic rats were subcategorized into uremia, PD2, VEGF shRNA-2, vector-2, PD2 + Endostar, PD4, VEGF shRNA-4, Vector-4, and PD4 + Endostar groups. Peritoneal Equilibration Test (PET) was conducted to assess ultrafiltration volume (UFV) and… Show more

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Cited by 4 publications
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“…The efficiency of VEGFA knockdown was determined by qPCR. The VEGFA shRNA sequences were 5 ′ -GATCCGGCCAGCACATAGGAGTTC AAGAGAAGATTCAAGACGTCTCTCCTATGTGCTGG CCTTTTTTGTCGACA-3 ′ (sense) and 3 ′ -GCCGGTCGT GTATCCTCAAGTTCTCTTCTAAGTTCTGCAGAGAGG ATACACGACCGGAAAAAACAGCTGTTCGA-5 ′ (antisense) [33].…”
Section: Generation Of Stablementioning
confidence: 99%
“…The efficiency of VEGFA knockdown was determined by qPCR. The VEGFA shRNA sequences were 5 ′ -GATCCGGCCAGCACATAGGAGTTC AAGAGAAGATTCAAGACGTCTCTCCTATGTGCTGG CCTTTTTTGTCGACA-3 ′ (sense) and 3 ′ -GCCGGTCGT GTATCCTCAAGTTCTCTTCTAAGTTCTGCAGAGAGG ATACACGACCGGAAAAAACAGCTGTTCGA-5 ′ (antisense) [33].…”
Section: Generation Of Stablementioning
confidence: 99%