2002
DOI: 10.1007/s005400200042
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Effects of ropivacaine on membrane potential and voltage-dependent calcium channel current in single guinea-pig ventricular myocytes

Abstract: Ropivacaine has an inhibitory effect on I(Ca) in the guinea-pig single ventricular myocyte. It is concluded that the mild negative inotropic effect induced by ropivacaine can be attributed in part to shortening of the duration of the action potential, which is caused by inhibition of I(Ca).

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Cited by 2 publications
(3 citation statements)
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“…cant from 30 mmol l À1 , and half maximal block occurred close to 300 mmol l À1 . The magnitude of I Ca inhibition, induced by articaine and ropivacaine in the present study, is in good agreement with previous results obtained in canine and guinea pig ventricular cells [19,20,28,29].…”
Section: Mechanism Of the Negative Inotropic Action Of Articaine And supporting
confidence: 95%
“…cant from 30 mmol l À1 , and half maximal block occurred close to 300 mmol l À1 . The magnitude of I Ca inhibition, induced by articaine and ropivacaine in the present study, is in good agreement with previous results obtained in canine and guinea pig ventricular cells [19,20,28,29].…”
Section: Mechanism Of the Negative Inotropic Action Of Articaine And supporting
confidence: 95%
“…Acquisition and analysis of the data were performed by Pulse and Pulsefit software (Heka). The compositions of internal and external solutions were essentially the same as those used in our previous studies (Hatakeyama et al, 2002;. In general, the L-type Ca 2+ current (ICa) was elicited by a 200 ms depolarizing test pulse to +10 mV from a holding potential (VH) of -30 mV in order to avoid the Na + current (INa) and the T-type Ca 2+ current.…”
Section: Measurements Of Action Potentials and Membrane Currentsmentioning
confidence: 99%
“…Single atrial myocytes of the guinea pig were obtained by enzymatic dispersion (Hatakeyama et al, 2002). The hearts were excised and the ascending aorta was cannulated with a dull-edged needle.…”
Section: Measurements Of Action Potentials and Membrane Currentsmentioning
confidence: 99%