Effects of rostral medial forebrain bundle and olfactory tubercle lesions upon sexual behavior of male rats.

Hitt, John C.; Bryon, David M.; Modianos, Doan T.

doi:10.1037/h0033797

Cited by 39 publications

(16 citation statements)

References 18 publications

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“…Because this projection is monosynaptic, pheromonal information transmitted by this pathway may be subject to limited signal modification and could be involved in mediating the reinforcing effects of opposite-sex odors. Indeed, the mOT has been implicated in the reinforcing effects of cocaine, MDMA, and amphetamines (Ikemoto, 2003; Shin et al, 2008; Shin et al, 2010) and in male rat sexual behavior (Hitt et al, 1973). The mOT has also been hypothesized to play an important role in odor hedonics (Wesson & Wilson, 2011).…”

Section: Discussionmentioning

confidence: 99%

A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice

et al. 2014

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In rodents, many aspects of sociosexual behavior are mediated by chemosignals released by opposite-sex conspecifics. These chemosignals are relayed via the main (MOS) and accessory olfactory systems (AOS) to the medial amygdala (Me). The Me is subdivided into anterior (MeA) and posterior (MeP) subnuclei, and lesions targeting these regions have different effects on proceptive courtship behaviors in female mice. Differential behavioral effects of MeA vs. MeP lesions could reflect a difference in the projections of neurons located in these Me subnuclei. To examine this question, we injected female mice with the anterograde tracer, Fluoro-Ruby into either the MeA or MeP and quantified labeled puncta in 11 forebrain target sites implicated in courtship behaviors using confocal fluorescence microscopy. We found that the MeP more densely innervates the medial and intermediate regions of the posterior bed nucleus of the stria terminalis (pBNST) and the posteromedial cortical amygdala (PMCo), while the MeA more densely innervates the horizontal diagonal band of Broca (HDB) and the medial olfactory tubercle (mOT), a region that may be a component of the circuitry responsible for olfactory-mediated motivated behaviors.

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Section: Discussionmentioning

confidence: 99%

A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice

et al. 2014

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“…Elegant work by numerous groups has established that neurons within the NAc encode conditioned task-related events, including the instruction or trigger cues that signal subsequent outcomes, the preparation, initiation, and execution of behav- ioral actions, and the sensory properties of reinforcers (Apicella et al, 1991;Schultz et al, 1992;Williams et al, 1993;Hollerman et al, 1998;Hassani et al, 2001;Carelli, 2002;Setlow et al, 2003;Taha and Fields, 2005;Roesch et al, 2009). During goal-directed behaviors, the activity of rodent NAc neurons is characterized by anticipatory changes in firing preceding the operant response, followed by either an increase or decrease in firing after delivery of the reinforcer (Carelli et al, 1993(Carelli et al, , 2000Chang et al, 1996;Lee et al, 1998;Martin and Ono, 2000).…”

Section: Known Aspects Of Reward-related Encoding In the Ventral Strimentioning

confidence: 99%

“…Electrical stimulation of the OT is rewarding, with rats and mice readily selfadministering stimulation (Prado-Alcalá and Wise, 1984;FitzGerald et al, 2014). Similarly, lesions of the OT decrease mating behavior in male rats (Hitt et al, 1973) and abolish the preference of female mice for male chemosignals (Agustín-Pavó n et al, 2014;DiBenedictis et al, 2015). The OT is a target of dopaminergic neurons originating in the ventral tegmental area and may also modulate the salience of drugs of abuse (Ikemoto, 2003(Ikemoto, , 2007Ikemoto et al, 2005;Striano et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Neural Representation of Goal-Directed Actions and Outcomes in the Ventral Striatum's Olfactory Tubercle

Gadziola

Wesson

2016

J. Neurosci.

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The ventral striatum is critical for evaluating reward information and the initiation of goal-directed behaviors. The many cellular, afferent, and efferent similarities between the ventral striatum's nucleus accumbens and olfactory tubercle (OT) suggests the distributed involvement of neurons within the ventral striatopallidal complex in motivated behaviors. Although the nucleus accumbens has an established role in representing goal-directed actions and their outcomes, it is not known whether this function is localized within the nucleus accumbens or distributed also within the OT. Answering such a fundamental question will expand our understanding of the neural mechanisms underlying motivated behaviors. Here we address whether the OT encodes natural reinforcers and serves as a substrate for motivational information processing. In recordings from mice engaged in a novel water-motivated instrumental task, we report that OT neurons modulate their firing rate during initiation and progression of the instrumental licking behavior, with some activity being internally generated and preceding the first lick. We further found that as motivational drive decreases throughout a session, the activity of OT neurons is enhanced earlier relative to the behavioral action. Additionally, OT neurons discriminate the types and magnitudes of fluid reinforcers. Together, these data suggest that the processing of reward information and the orchestration of goal-directed behaviors is a global principle of the ventral striatum and have important implications for understanding the neural systems subserving addiction and mood disorders.

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“…In other mammal studies, the TUB also plays a role in behavior (Hitt et al, 1973). Bilateral lesioning has been found to reduce copulation in male rats (Hitt et al, 1973). Lesioning has also been found to cause hyperphagia and attenuates increases in locomotion associated with dextroamphetamine.…”

Section: The Retrobulbar Regionsmentioning

confidence: 99%

“…In other mammal studies, the TUB also plays a role in behavior (Hitt et al, 1973). Bilateral lesioning has been found to reduce copulation in male rats (Hitt et al, 1973).…”

Section: The Retrobulbar Regionsmentioning

confidence: 99%

Proliferation, Migration, and Survival of Cells in the Telencephalon of the Ball Python, Python Regius

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Effects of rostral medial forebrain bundle and olfactory tubercle lesions upon sexual behavior of male rats.

Cited by 39 publications

References 18 publications

A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice

A quantitative comparison of the efferent projections of the anterior and posterior subdivisions of the medial amygdala in female mice

The Neural Representation of Goal-Directed Actions and Outcomes in the Ventral Striatum's Olfactory Tubercle

Proliferation, Migration, and Survival of Cells in the Telencephalon of the Ball Python, Python Regius

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