Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis

Kırzıoğlu, Fatma Yeşim; Özmen, Özlem; Doğan, Burak; Bulut, Memduha Tözüm; Fentoğlu, Özlem; Özdem, Muhsin

doi:10.1111/jre.12513

Cited by 15 publications

(10 citation statements)

References 46 publications

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“…Various studies demonstrated a NOS-inhibiting effect by the use of statins. For instance, in vivo , rosuvastatin significantly reduced inflammation-mediated tissue destruction and gingival iNOS expression [54].…”

Section: Resultsmentioning

confidence: 99%

“…In 6 studies, animals with systemic diseases (i.e, osteoporosis [26, 91, 92], metabolic syndrome [32], cyclosporine A-associated alveolar bone loss [35], hyperlipidemia [54], or hypertension [93] were used to evaluate the effect of statins treatment. Overall, 22 studies involved treatment with simvastatin, 7 with atorvastatin, 3 with rosuvastatin, 2 with lovastatin, and only one with fluvastatin.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Contribution of Statins towards Periodontal Treatment: A Review

Petit

Batool

Bugueno

et al. 2019

Mediators of Inflammation

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The pleiotropic effects of statins have been evaluated to assess their potential benefit in the treatment of various inflammatory and immune-mediated diseases including periodontitis. Herein, the adjunctive use of statins in periodontal therapy in vitro, in vivo, and in clinical trials was reviewed. Statins act through several pathways to modulate inflammation, immune response, bone metabolism, and bacterial clearance. They control periodontal inflammation through inhibition of proinflammatory cytokines and promotion of anti-inflammatory and/or proresolution molecule release, mainly, through the ERK, MAPK, PI3-Akt, and NF-κB pathways. Moreover, they are able to modulate the host response activated by bacterial challenge, to prevent inflammation-mediated bone resorption and to promote bone formation. Furthermore, they reduce bacterial growth, disrupt bacterial membrane stability, and increase bacterial clearance, thus averting the exacerbation of infection. Local statin delivery as adjunct to both nonsurgical and surgical periodontal therapies results in better periodontal treatment outcomes compared to systemic delivery. Moreover, combination of statin therapy with other regenerative agents improves periodontal healing response. Therefore, statins could be proposed as a potential adjuvant to periodontal therapy. However, optimization of the combination of their dose, type, and carrier could be instrumental in achieving the best treatment response.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Contribution of Statins towards Periodontal Treatment: A Review

Petit

Batool

Bugueno

et al. 2019

Mediators of Inflammation

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show abstract

“…NO can also promote cytokine production and bone turnover besides indirect induction of bone resorption 3 . In this regard, periodontitis results in higher production of NO compared to healthy gingiva 4 . Periodontal treatment may involve the use of several systemic antibiotics such as tetracycline (minocycline and doxycycline) as adjuvants due to its local distribution.…”

Section: Introductionmentioning

confidence: 99%

Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis

et al. 2021

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Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated the potential of host defense peptides clavanins A, MO, and LL-37 in in vitro osteoclastogenesis. Methods: RAW 264.7 cultures were stimulated with recombinant of receptor activator of nuclear factor kappa B ligand in the presence of different tested concentrations of host defense peptides, besides calcium hydroxide and doxycycline. Cellular viability, nitric oxide production, and a number of differentiated osteoclast-like cells were also evaluated. Results: Results showed that none of the substances were cytotoxic, except for 128 μg.mL-1 of doxycycline after 3 days. Host defense peptides, calcium hydroxide, and doxycycline did not interfere in nitric oxide production or downregulated it. An exception was observed in the presence of 2 μg.mL-1 of doxycycline, in which nitric oxide production was up-regulated. All host defense peptides were capable of reducing osteoclast-like cell differentiation. Conclusion: Host defense peptides clavanins A and MO demonstrated to be potential suppressors of osteoclastogenesis in vitro without interfering in cellular viability and nitric oxide production. These promising results need to be further analyzed in in vivo models of bone resorption.

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“…A good adjuvant response in both surgical and nonsurgical periodontal treatment has been shown in recent years by natural agents. Especially in the non-surgical approach, various antimicrobials and chemotherapy agents, including chlorhexidine, triclosan, desiccant agents, vitamin and probiotic compounds, and cetylpyridinium chloride, have been studied and validated for the management of periodontitis [24][25][26][27][28][29]. However, even more studies have aimed at analyzing phytotherapeutic drugs in order to obtain antimicrobial, antiseptic, anti-inflammatory, and antioxidant effects during periodontitis.…”

mentioning

confidence: 99%

Current Evidence of Natural Agents in Oral and Periodontal Health

Isola

2020

Nutrients

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Oral and periodontal diseases, chewing disorders, and many destructive inflammatory diseases of the supporting tissues of the teeth are usually caused by an imbalance between host defense and environmental factors like smoking, poor nutrition, and a high percentage of periodontopathogenic bacteria. For these reasons, it is important also to focus attention on plaque control and also on improving host resistance through smoking and stress reduction, and a healthy diet. During the last decades, the importance of micronutrients has been extensively reviewed, and it was concluded that the prevention and treatment of periodontitis should include correct daily nutrition and a correct balance between antioxidants, probiotics, natural agents, vitamin D, and calcium. Recently, there has been growing interest in the literature on the impact of nutraceutical dietary aliments on oral and general health. This Special Issue provides a current and thoughtful perspective on the relationship of diet and natural agents on oral and periodontal diseases through a correct clinical approach with the last and most important evidence that may determine good oral conditions and high quality of life.

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Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis

Cited by 15 publications

References 46 publications

Contribution of Statins towards Periodontal Treatment: A Review

Contribution of Statins towards Periodontal Treatment: A Review

Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis

Current Evidence of Natural Agents in Oral and Periodontal Health

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