Effects of routine oral iron supplementation with or without folic acid for women during pregnancy

Peña‐Rosas, Juan Pablo; Viteri, Fernando E.

doi:10.1002/14651858.cd004736.pub2

Cited by 138 publications

(137 citation statements)

References 131 publications

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“…There is insufficient (or no) evidence on the effect on preeclampsia of supplementation with: iron (routinely, or not, or routinely with/without folic acid) [243], pyridoxine [244], garlic, vitamin A, selenium, copper, or iodine.…”

Section: Preventing Preeclampsia and Its Complicationsmentioning

confidence: 99%

“…Any antihypertensive therapy will, compared with placebo or no therapy: decrease transient severe hypertension (RR 0.50; 95% CI 0.41-0.61) without a difference in other outcomes, including preeclampsia or preterm delivery [243]. However, antihypertensive lowering of BP may reduce fetal growth velocity [61,247,248]); not all subsequently published data are consistent with this [344].…”

Section: Commentsmentioning

confidence: 99%

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RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

Magee

Pels

Helewa

et al. 2008

Journal of Obstetrics and Gynaecology Canada

421

218

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Section: Preventing Preeclampsia and Its Complicationsmentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

Magee

Pels

Helewa

et al. 2008

Journal of Obstetrics and Gynaecology Canada

421

218

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“…10 Several randomized control trials (RCTs) and meta-analyses have observed that routine iron supplementation is not of much use. 11 Few of the studies have also shown that increase in the Hb beyond a certain level could in fact have a negative outcome. 12 Objective of present study was to find association between maternal anaemia and neonatal complications and to find long term morbidity and mortality of babies born to anaemic mothers.…”

Section: Introductionmentioning

confidence: 99%

Effect of anemia on pregnancy outcome: a prospective study at tertiary care hospital

Upadhyay

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Iron deficiency anaemia during pregnancy leads to preterm birth, low birth weight and small-for-gestational age babies and increases incidence of postpartum haemorrhage (PPH) and the reason for the incidence of PPH is higher in India compared with the rest of the world. The objective of this study was to find association between maternal anaemia and neonatal complications and to find long term morbidity and mortality of babies born to anaemic mothers.Methods: It is a prospective study done at Obstetrics and Gynecology Department, Dr. B. R. Ambedkar Medical College and Hospital, Bangalore during October 2009 to October 2011. All subjects were analyzed in full details and haemoglobin estimation done during 1st visit, at 30th week and 36th week of gestation.Results: Study observed moderate anaemia observed in almost 53.0% cases followed by mild (29.5%) and severe (17.5%) respectively. Risk factors present in 58.0% cases and maternal complications in puerperium observed in 14.5% cases. High incidence of adverse foetal outcome in the form of preterm (20%), IUGR (28%), NICU admission (25.5%) and IUD (3%) seen in present study. Study found association between space between pregnancy, LSCS and fetal outcome with severity of anaemia. Ensuring maternal iron sufficiency during gestation is the most cost-effective method of preventing perinatal iron deficiency and related morbidities.Conclusions: Iron supplementation during pregnancy in iron deficient mothers improves iron status during pregnancy and postpartum period, thus providing some protection against iron deficiency in the subsequent pregnancy. Proper antenatal care is the basic requirement for prevention, early detection and treatment of anaemia.

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“…The detrimental public health effects of ID include anaemia, decreased intellectual and work performance, and functional alterations of the small bowel (4,5) . Besides other vulnerable age groups such as infancy and early childhood, adolescence is also considered a high-risk period for developing ID owing to the combination of rapid physical growth and losses of Fe through menstruation (4) .…”

mentioning

confidence: 99%

Iron status of adolescent girls from two boarding schools in southern Benin

Alaofè

Zee

Dossa

et al. 2008

Public Health Nutr.

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Iron deficiency (ID) is the most prevalent micronutrient deficiency in the world, particularly in developing countries. Blood samples and a qualitative FFQ on Feand vitamin C-rich foods were obtained in 180 adolescent girls aged 12 to 17 years living in two boarding schools from south Benin. ID, defined as serum ferritin either ,20 mg/l or 20-50 mg/l, plus two of the following parameters: serum Fe , 11 mmol/l, total iron-binding capacity . 73 mmol/l or transferrin saturation , 20 %, was found in 32 % of subjects. Anaemia (Hb , 120 g/l) was found in 51 % of adolescents, while 24 % suffered from iron-deficiency anaemia (IDA) (ID and Hb , 20 g/l). After adjusting for confounding factors (age, mother's and father's occupation, household size) in a logistic regression equation, subjects having a low meat consumption (beef, mutton, pork) (,4 times/week) were more than twice as likely to suffer from ID (OR 5 2?43; 95 % CI 1?72, 3?35; P 5 0?04). Adolescents consuming less fruits (,4 times/week) also had a higher likelihood of suffering from ID (OR 5 1?53; 95 % CI 1?31, 2?80; P 5 0?03). Finally, subjects whose meat consumption was low were twice as likely to suffer from IDA (OR 5 2?24; 95 % CI 1?01, 4?96; P 5 0?04). The prevalence of ID represents an important health problem in these Beninese adolescent girls. A higher consumption of Fe-rich foods and of promoters of Fe absorption (meat factor and vitamin C) is recommended to prevent ID deficiency in these subjects.

show abstract

Effects of routine oral iron supplementation with or without folic acid for women during pregnancy

Abstract: Further studies are needed to assess the effects of routine antenatal supplementation with iron or a combination of iron and folic acid on clinically important maternal and infant outcomes.

Cited by 138 publications

References 131 publications

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

Effect of anemia on pregnancy outcome: a prospective study at tertiary care hospital

Iron status of adolescent girls from two boarding schools in southern Benin

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