Effects of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini Extracts on Melanin Synthesis in Melanoma Cells

Kim, Min-Gon; Kim, Seoyeon; Hyun, Kwang Hee; Kim, Duk Soo; Kim, Seung-Young; Hyun, Chang‐Gu

doi:10.7841/ksbbj.2017.32.3.187

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Tyrosinase, the main enzyme in the melanin biosynthesis pathway, promotes the hydroxylation of L-tyrosine to L-DOPA (L-3,4-dihydroxyphenylalanine), and then promotes the oxidation of L-DOPA to dopachrome and dopaquinone, which synthesizes melanin through the auto-oxidation process by tyrosinase-related proteins (TRP-1 and 2) through several stages [ 4 , 5 , 6 ]. To date, methods of inhibiting melanin formation by impeding tyrosinase-related proteins have been widely used in the cosmetics industry for the development of skin-whitening agents [ 7 , 8 ]. However, kojic acid, azelaic acid, and hydroquinone, conventionally used skin-whitening ingredients, have been reported to induce allergies as well as cause skin toxicity and cancer [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Sargassum thunbergii Extract on Skin Whitening and Anti-Wrinkling through Inhibition of TRP-1 and MMPs

et al. 2021

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Sargassum thunbergii has been traditionally used as an edible and medicinal material in oriental countries. However, the skin-whitening and anti-wrinkling effects of S. thunbergii have not yet been investigated. This study was conducted to establish optimal extraction conditions for the production of bioactive compounds with antioxidant activity as well as skin-whitening and anti-wrinkle effects using ultrasound-assisted extraction (UAE) in S. thunbergii. The extraction time (5.30~18.7 min), extraction temperature (22.4~79.6 °C), and ethanol concentration (0.0~99.5%), which are the main variables of the UAE, were optimized using a central composite design. Quadratic regression equations were derived based on experimental data and showed a high coefficient of determination (R2 > 0.85), demonstrating suitability for prediction. The optimal UAE condition for maximizing all dependent variables, including radical scavenging activity (RSA), tyrosinase inhibitory activity (TIA), and collagenase inhibitory activity (CIA), was identified as an extraction time of 12.0 min, an extraction temperature of 65.2 °C, and ethanol of 53.5%. Under these conditions, the RSA, TIA, and CIA of S. thunbergii extract were 86.5%, 88.3%, and 91.4%, respectively. We also confirmed S. thunbergii extract had inhibitory effects on the mRNA expression of tyrosinase-related protein-1, matrix metalloproteinase-1, and matrix metalloproteinase-9, which are the main genes of melanin synthesis and collagen hydrolysis. Liquid chromatography-tandem mass spectrometry was used to identify the main phenolic compounds in S. thunbergii extract, and caffeic acid was identified as a major peak, demonstrating that high value-added ingredients with skin-whitening and anti-wrinkling effects can be produced from S. thunbergii and used for developing cosmetic materials.

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Section: Introductionmentioning

confidence: 99%

Effects of Sargassum thunbergii Extract on Skin Whitening and Anti-Wrinkling through Inhibition of TRP-1 and MMPs

et al. 2021

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“…E. jolkinii is a medicinal plant material, and leaves and stems have been used as medicinal materials in oriental medicine. To verify and exploit these effects, studies on the pharmacological effects of extracts including their antioxidant and antibacterial activities, as well as melanin synthesis in melanoma cells have been conducted (Park et al 2005;Kim et al 2006;Kim et al 2017). In addition, the unique, large flower structure and herbivorous form of E. jolkinii are considered to be of high ornamental value.…”

Section: Introductionmentioning

confidence: 99%

Non-deep physiological dormancy in seeds of Euphorbia jolkinii Boiss. native to Korea

Shin

Lee

et al. 2021

j ecology environ

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Background Euphorbia jolkinii Boiss. is a perennial species native to Jeju Island and the southern coastal area of Korea. Particularly on Jeju Island, the yellow flowers of E. jolkinii Boiss. have a high ornamental value because of their contrast with basalt. This study was conducted to investigate the effects of different temperatures (5, 15, 20, and 25 °C) and gibberellic acid (GA3) concentrations (0, 10, 100, or 1000 mg/L) on seed dormancy and germination of E. jolkinii. In addition, we classified the seed dormancy type and compared types with those of other species in the same genus. Results The number of seeds with viable embryos and endosperms was approximately 66%. The final germination percentages at 5, 15, 20, and 25 °C were 51.7%, 83.5%, 2.6%, and 0.0%, respectively. In GA3 concentration experiments, the final germination percentages of 0, 10, 100, and 1000 mg/L were 83.5%, 91.7%, 79.1%, and 83.4%, respectively, at 15 °C conditions, and 0.0%, 6.9%, 13.2%, and 27.3%, respectively, at 25 °C. Conclusions Germination improved at temperatures of 15 °C or lower. Furthermore, GA3 treatment effectively reduced germination times. Thus, the seeds of E. jolkinni were classified as having non-deep physiological dormancy.

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“…Extracts and various fractions from E. nematocypha have shown important biological activities, including anti-respiratory syncytial virus ( Huang et al, 2014 ), activities against Gram-negative and Gram-positive bacteria, and can scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, superoxide radicals, and nitric oxide radicals ( Kim et al, 2006 ). As whitening functional cosmetic, E. nematocypha extracts reduce melanin production in B16F10 melanoma cells ( Kim et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and molecular-docking approach of a new rosane-type diterpenoid from the roots of Euphorbia nematocypha

et al. 2022

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A new rosane-type diterpenoid (1) along with nine known diterpenoids (2–10), were isolated from the dried roots of Euphorbia nematocypha. The absolute configuration was elucidated from spectroscopic (nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and electronic circular dichroism) and optical-rotation analyses. Cytotoxicity and the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl radicals were determined. Compound 1 showed remarkable cytotoxicity against human cancer cell lines (HeLa, CT26, and HCC 1806) in vitro. The interaction between compound 1 and proteins of ribosomal S6 kinase was revealed using molecular docking and provided valuable insights into the cytotoxic mechanism of action of compound 1. The latter could be developed as a pharmaceutical agent in the future.

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Effects of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini Extracts on Melanin Synthesis in Melanoma Cells

Cited by 4 publications

References 15 publications

Effects of Sargassum thunbergii Extract on Skin Whitening and Anti-Wrinkling through Inhibition of TRP-1 and MMPs

Effects of Sargassum thunbergii Extract on Skin Whitening and Anti-Wrinkling through Inhibition of TRP-1 and MMPs

Non-deep physiological dormancy in seeds of Euphorbia jolkinii Boiss. native to Korea

Cytotoxicity and molecular-docking approach of a new rosane-type diterpenoid from the roots of Euphorbia nematocypha

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