Effects of Rutin on Lipid Profile in Hypercholesterolaemic Rats

Ziaee, Amir; Zamansoltani, Farzaneh; Nassiri‐Asl, Marjan; Abbasi, Esmail

doi:10.1111/j.1742-7843.2008.00368.x

Cited by 79 publications

(47 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, rutin administered to H-fed rats attenuated the diet-induced metabolic syndrome, NASH, and cardiovascular abnormalities. Rutin lowered the lipid components in the serum of hypercholesterolemic rats, probably by reducing the activity of HMG-CoA reductase (53). In our study, rutin-treated rats had lower plasma concentrations of total cholesterol, TG, NEFA, and insulin.…”

Section: Discussionmentioning

confidence: 56%

Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats

Panchal¹,

Poudyal²,

Arumugam³

et al. 2011

The Journal of Nutrition

155

113

View full text Add to dashboard Cite

Metabolic syndrome (obesity, diabetes, and hypertension) increases hepatic and cardiovascular damage. This study investigated preventive or reversal responses to rutin in high-carbohydrate, high-fat diet-fed rats as a model of metabolic syndrome. Rats were divided into 6 groups: 2 groups were fed a corn starch-rich diet for 8 or 16 wk, 2 groups were fed a high-carbohydrate, high-fat diet for 8 or 16 wk, and 2 groups received rutin (1.6 g/kg diet) in either diet for the last 8 wk only of the 16-wk protocol. Metabolic changes and hepatic and cardiovascular structure and function were then evaluated in these rats. The corn starch-rich diet contained 68% carbohydrate (mainly cornstarch) and 0.7% fat, whereas the high-carbohydrate, high-fat diet contained 50% carbohydrate (mainly fructose) and 24% fat (mainly beef tallow) along with 25% fructose in drinking water (total 68% carbohydrate using mean food and water intakes). The high-carbohydrate, high-fat diet produced obesity, dyslipidemia, hypertension, impaired glucose tolerance, hepatic steatosis, infiltration of inflammatory cells in the liver and the heart, higher cardiac stiffness, endothelial dysfunction, and higher plasma markers of oxidative stress with lower expression of markers for oxidative stress and apoptosis in the liver. Rutin reversed or prevented metabolic changes such as abdominal fat pads and glucose tolerance, reversed or prevented changes in hepatic and cardiovascular structure and function, reversed oxidative stress and inflammation in the liver and heart, and normalized expression of liver markers. These results suggest a non-nutritive role for rutin to attenuate chronic changes in metabolic syndrome.

show abstract

Section: Discussionmentioning

confidence: 56%

Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats

Panchal¹,

Poudyal²,

Arumugam³

et al. 2011

The Journal of Nutrition

155

113

View full text Add to dashboard Cite

show abstract

“…In the present study, rutin-supplement attenuated HCD-induced hepatotoxicity by lowering the concentrations of TC, TG and LDL. Similarly, rutin lowers the lipid components in the serum of hyper-cholesterolemic rats, probably by reducing the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase [60]. This may be explained on the basis that rutin has a strong ability to chelate multivalent metal ions, especially zinc, calcium and iron [39].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat

Al-Rejaie

Aleisa

Sayed‐Ahmed

et al. 2013

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundHigh-cholesterol diet (HCD) increases the oxidative stress in different tissues leading to many diseases. Rutin (RT) is a natural flavonoid (vitamin p), which possesses an antioxidant activity with protective potential. The present study aimed to examine the potential effects of rutin on hypercholesterolemia-induced hepatotoxicity in rat.MethodsMale Wistar rats were divided into four groups: GI) control (Rat chow), GII) Rutin (0.2% in rat chow), GIII) HCD (1% cholesterol and 0.5% cholic acid in rat chow) and GIV) rutin (0.2%) + HCD.ResultsRutin in combination with HCD induced a significant protective effect against the hepatotoxicity by reducing the plasma level of alanine transaminase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL). The HCD (GII) showed a decrease in glutathione peroxidase (GPx), glutathione reductase (GR) and increase in glutathione S transferase α (GSTα), sulfiredoxin-1(Srx1), glutamate-cysteine ligase (GCL) and paraoxonase-1(PON-1) genes expression levels.ConclusionTreatment with rutin reversed all the altered genes induced by HCD nearly to the control levels. The present study concluded that the HCD feedings altered the expression levels of some genes involved in the oxidative stress pathway resulting in DNA damage and hepatotoxicity. Rutin have a hepatoprotective effect through the mechanism of enhancing the antioxidant effect via amelioration of oxidative stress genes.

show abstract

“…Rats were divided into six treatment groups (Table 1). One mL of 2.5% cholesterol and 1 mL of each vinegar sample was administered daily by oral gavage [15] for 7 weeks; vinegars were orally gavaged at 9 am and cholesterol solution was orally gavaged at 5 pm during the experiment. The control-diet (CNT) group received 1 mL of normal saline solution concurrently with the experiment groups.…”

Section: Experimental Designmentioning

confidence: 99%

Effects of Grape Wine and Apple Cider Vinegar on Oxidative and Antioxidative Status in High Cholesterol-Fed Rats

Seydim¹,

Güzel‐Seydim²,

Doğuç³

et al. 2016

FFHD

View full text Add to dashboard Cite

Background:Oxidative stress is the result of an imbalance between the rates of free radical production and elimination via endogenous antioxidant mechanisms such as antioxidant enzymes, which include glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT). There are mainly two vinegar production methods. The first is the surface method which is also known as the traditional method. The second method is known as the industrial method or submerged method which involves the use of a submerged culture with supplemented aeration.Objective: The aim of this study is to determine the effects of grape and apple cider vinegar consumption against oxidative stress in rats fed a high cholesterol diet.Methods: Fifty-four male, adult Wistar albino rats were included in this study. Rats were fed for 7 weeks by oral gavage as given in the experimental procedure. Rats were sacrificed at the end of the experiment and blood samples were collected. Catalase (CAT) activity, malondialdehyde level (MDA), glutathione peroxidase (GSH-Px) activity, superoxide dismutase (SOD) activity were analyzed. Grape and apple vinegar fermentation products prepared using both the surface culture method and submerged methods were prepared. The total antioxidant activity of vinegar samples were measured by Oxygen Radical Absorbance Capacity (ORAC) and 2,2'-azinobis (3-ethlybenzthiazoline)-6-sulfonic acid (ABTS) methods. Results: Levels of CAT, GSH-Px, SOD in high cholesterol diet group (CHCNT) were significantly decreased while MDA levels were significantly increased in control rats fed with the high-cholesterol diet (CHCNT) when compared to the Control group (CNT) (P<0.05). Levels of MDA, which is the end-product of lipid peroxidation, were significantly decreased in the apple cider vinegar administered groups when compared to the CHCNT (P<0.05). GSH-Px levels were significantly increased in rat groups, which were fed with the vinegars produced by traditional surface methods (P=0.03, P=0.001 respectively) as compared to the CHCNT. SOD levels of rat groups which were fed with all the vinegars were significantly increased as compared to CHCNT group (p<0.05). Conclusions:This study indicated that a high cholesterol diet increased lipid peroxidation and consumed the antioxidant enzymes. Although the impact of vinegars on antioxidant enzyme activity differs, the use of vinegar and especially vinegars produced by surface culture methods seem to have favorable effect in vivo.

show abstract

Effects of Rutin on Lipid Profile in Hypercholesterolaemic Rats

Cited by 79 publications

References 39 publications

Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats

Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats

Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat

Effects of Grape Wine and Apple Cider Vinegar on Oxidative and Antioxidative Status in High Cholesterol-Fed Rats

Contact Info

Product

Resources

About