Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

Yang, Xin; Tang, Ting; Wen, Jing; Li, Mengchun; Chen, Jie; Li, Tingyu; Dai, Ying; Qian, Cheng

doi:10.1186/s12866-021-02231-0

Cited by 4 publications

(5 citation statements)

References 31 publications

(30 reference statements)

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“…However, the beta-diversity analysis showed significant differences in the gut microbiota structure of the two groups. These results have been published before [ 21 , 24 ].…”

Section: Discussionsupporting

confidence: 69%

“…A recent study of adverse drug reactions in pregnant women showed that the incidence of immune-related adverse events associated with ceftriaxone sodium was 18.4% [ 20 ], which may result in gut microbiota imbalance because of changes in the abundance of dominant taxa. Previously, we added ceftriaxone sodium to the drinking water of Sprague–Dawley rats during pregnancy and found the effect of ceftriaxone sodium on the weight of offspring, bacterial DNA sequencing also showed that structure of gut microbiota was markedly disrupted in the pregnant rats [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Vascular Endothelial Growth Factor May Be Involved in the Behavioral Changes of Progeny Rats after Exposure to Ceftriaxone Sodium during Pregnancy

Yang

Tang

et al. 2022

J. Microbiol. Biotechnol.

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Antibiotics have been used in recent years to treat many pregnancy-related diseases [1] and the risk is also increasing [2]. Newborns of mothers who were treated with and without antibiotics during pregnancy show markedly different growth profiles and there is increasing but controversial evidence that exposure to antibiotics during pregnancy may have short-term and long-term effects on babies. The potential behavioral changes of future generations constitute one of the controversies surrounding this phenomenon.Studies [3][4][5] suggest that maternal exposure to antibiotics modifies the intestinal microbiome, thus causing maternal immune activation, which may lead to abnormal neurodevelopment and behavioral abnormalities in the offspring. Maternal intestinal microecological disorders may disrupt gut-brain axis of fetus in the uterus and play a role in the occurrence of neurodevelopmental disorders [6,7]. However, a population cohort study by Hamad et al. [8] found no direct association between prenatal antibiotic exposure and increased risk of childhood ADHD. Similarly, Atladóttir et al. [9] also did not find that antibiotic use during pregnancy is an important risk factor for autism spectrum disorder (ASD) or infant autism, a disease known to be associated with maternal immune activation. For these reason that effects of antibiotic exposure during pregnancy on offspring neurodevelopment and behavior needs to be further explored.Antibiotics act through the gut microbiome, maintaining normal physiology in the body through their metabolites [10]. It was also confirmed [11] that antibiotics can alter the structure of the gut microbiome and affect the abundance of metabolites, resulting in a therapeutic effect on necrotizing enterocolitis. Yu et al. [12] had found that antibiotic-induced gut microbiome disorders in rats markedly disrupted metabolic pathways related to glycine, serine, and threonine metabolism, niacin and nicotinamide metabolism, and bile acid metabolism. Kimura et al. [13] found that the relative abundance of five metabolites differed between specific-pathogen-free (SPF) mice and germ-free (GF) mice during pregnancy, and the plasma levels of short-chain fatty acids (such as Antibiotic exposure during pregnancy have an adversely effects on offspring behavior and development. However, its mechanism is still poorly understood. To uncover this, we added ceftriaxone sodium to the drinking water of rats during pregnancy and conducted three-chamber sociability test, open-field test, and Morris water maze test in 3-and 6-week-old offspring. The antibiotic group offspring showed lower sociability and spatial learning and memory than control. To determine the role of the gut microbiota and their metabolites in the changes in offspring behavior, fecal samples of 6-week-old offspring rats were sequenced. The composition of dominant gut microbial taxa differed between the control and antibiotic groups. KEGG pathway analysis showed that S24-7 exerted its effects through the metabolic pathways including mineral ...

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“…However, the beta-diversity analysis showed significant differences in the gut microbiota structure of the two groups. These results have been published before [ 21 , 24 ].…”

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor May Be Involved in the Behavioral Changes of Progeny Rats after Exposure to Ceftriaxone Sodium during Pregnancy

Yang

Tang

et al. 2022

J. Microbiol. Biotechnol.

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“…It was possibly correlated with the antiobesity effect of TSs. In addition, as another gut metabolite correlated with body weight, glutaric acid was also involved in fatty acid degradation . In our study, a potentially beneficial effect of TSs was linked to the modulation of fatty acid metabolism by affecting gut microbiota.…”

Section: Discussionmentioning

confidence: 54%

“…In addition, as another gut metabolite correlated with body weight, glutaric acid was also involved in fatty acid degradation. 65 In our study, a potentially beneficial effect of TSs was linked to the modulation of fatty acid metabolism by affecting gut microbiota. However, further studies are needed in the future to explore the potential role of other intestinal bacteria in host metabolism of fatty acids by TSs intervention in HFD-induced obesity.…”

Section: Discussionmentioning

confidence: 67%

Total Sesquiterpenoids of Loquat Leaves Alleviated High-Fat Diet-Induced Obesity by Targeting Fecal Metabolic Profiling and Gut Microbiota Composition

Jian

Zhou

Chen

et al. 2022

J. Agric. Food Chem.

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In the present study, we demonstrated that whether the gut microbiota and related metabolites contribute to the therapeutic effect of total sesquiterpenoids (TSs) from loquat leaves on obesity. A 4-week high fat diet was used to induce obesity which was then treated with TSs for another 4 weeks. TSs remarkedly reduced the weight of body and white adipose and the levels of total cholesterol (TC) and triglyceride (TG) in serum. We also found that TSs restored the diversity and richness of gut microbiota. In addition, TSs administration affected the relative abundance of seven key genera. Meanwhile, TSs were determined to affect the metabolism of the host through detecting the metabolites in feces. By applying KEGG and the correlation analysis with gut microbiota, 10 differential metabolites were identified to be the key. The results in this work proved that TSs inhibited obesity by remodeling gut microbiota and related metabolites.

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“…At the family level, S24-7, Ruminococcaceae , and Lachnospiraceae were the most abundant in rabbits. S24-7 is negatively correlated with BW and had long-term adverse effects on growth ( 33 ), and plays important roles in amino acid metabolism and intestinal mucosal immunity ( 34 ). The decreased relative abundance of S24-7 implied the improved role of the addition of yucca extract and C. butyricum to rabbit feed.…”

Section: Discussionmentioning

confidence: 99%

Dietary yucca extract and Clostridium butyricum promote growth performance of weaned rabbits by improving nutrient digestibility, intestinal development, and microbial composition

Wang

Zhang²,

Ren³

et al. 2023

Front. Vet. Sci.

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Yucca has abundant amounts of polyphenolics, steroidal saponins, and resveratrol and its extract can be used as a feed additive in the animal husbandry, which might contribute to the improvement in the growth and productivity in rabbit production. Hence, the current study aimed to examine the effects of yucca extract alone and in combination with Clostridium butyricum (C. butyricum) on growth performance, nutrient digestibility, muscle quality, and intestinal development of weaned rabbits. A total of 400 40-day-old male rabbits were randomly divided into 4 treatment groups for 40 days: (1) basal diet group, (2) basal diet contained 300 mg/kg of yucca extract, (3) basal diet supplemented with 0.4 × 1010 colony-forming units (CFU)/kg of C. butyricum, and (4) the blend of 0.4 × 1010/kg CFU of C. butyricum and 300 mg/kg of yucca extract. The supplementation of yucca extract or C. butyricum increased body weight (BW) of rabbits depending on the age, the combined addition of yucca extract and C. butyricum significantly increased BW, weight gain, and feed intake, companying with increased the digestibility of crud protein, fiber, phosphorous, and calcium as compared to control diet (P < 0.05). Furthermore, yucca extract and C. butyricum treatment alone and in combination notably increased the villus high and the ratio of villus high to crypt depth of rabbits (P < 0.05). The combined supplementation of yucca extract and C. butyricum altered the intestinal microbiota of rabbits, as demonstrated by increased the abundance of beneficial bacteria Ruminococcaceae and decreased the proportion of pathogenic bacteria such as Pseudomonadaceae and S24-7. In addition, the rabbits fed the diet with yucca extract and the blend of yucca extract and C. butyricum had significantly increased pH45min, decreased pressing loss, drip loss, and shears force when compared with rabbits received control diet (P < 0.05). Diet with C. butyricum or its mixture with yucca extract increased the fat content of meat, while the combined addition of yucca extract and C. butyricum declined the content of fiber in meat (P < 0.05). Collectively, the combined use of yucca extract and C. butyricum showed better results on growth performance and meat quality, which might be closely associated with the improved intestinal development and cecal microflora of the rabbits.

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Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

Cited by 4 publications

References 31 publications

Vascular Endothelial Growth Factor May Be Involved in the Behavioral Changes of Progeny Rats after Exposure to Ceftriaxone Sodium during Pregnancy

Vascular Endothelial Growth Factor May Be Involved in the Behavioral Changes of Progeny Rats after Exposure to Ceftriaxone Sodium during Pregnancy

Total Sesquiterpenoids of Loquat Leaves Alleviated High-Fat Diet-Induced Obesity by Targeting Fecal Metabolic Profiling and Gut Microbiota Composition

Dietary yucca extract and Clostridium butyricum promote growth performance of weaned rabbits by improving nutrient digestibility, intestinal development, and microbial composition

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