2008
DOI: 10.1016/j.jep.2008.02.024
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Effects of San-Huang-Xie-Xin-Tang on U46619-induced increase in pulmonary arterial blood pressure

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Cited by 34 publications
(22 citation statements)
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“…We demonstrate that SHXT attenuates lipopolysaccharide (LPS) and Helicobacter pylori -induced inflammatory responses [1012]. We also reveal the potential benefits of SHXT used in the treatment of pulmonary hypertension [13]. We further prove the potential protective mechanisms of SHXT on activated microglia- and 6-OHDA-induced neurotoxicity via its anti-inflammatory and antioxidative properties [14].…”
Section: Introductionmentioning
confidence: 96%
“…We demonstrate that SHXT attenuates lipopolysaccharide (LPS) and Helicobacter pylori -induced inflammatory responses [1012]. We also reveal the potential benefits of SHXT used in the treatment of pulmonary hypertension [13]. We further prove the potential protective mechanisms of SHXT on activated microglia- and 6-OHDA-induced neurotoxicity via its anti-inflammatory and antioxidative properties [14].…”
Section: Introductionmentioning
confidence: 96%
“…Several herbs in BSYSC that we studied were also known to play important roles in inhibitory signal pathway. For examples, gastrodin, the main constituent of Gastrodiae Rhizoma , down-regulated the expression of the neuronal cytoskeleton remodeling-related negative regulators Slit1 and RhoA in the hippocampus of rat model of depression [60], San-Huang-Xie-Xin-Tang containing Rhei Radix et Rhizoma attenuated ROCK-II protein expression in U46619-induced primary pulmonary smooth muscle cells [61]; additionally, Leonuri Herba , Scorpio and Gastrodiae Rhizoma were shown have neuroprotective and neuroregenerative effect in vivo and in vitro [6265]. Moreover, the molecules identified in BSYSC like forsythiaside, acteoside were reported for neuroprotective effects [6671].…”
Section: Discussionmentioning
confidence: 99%
“…The NO 2 − concentration originally included in wax gourd juice is not as high as the concentration of NO 3 − (Zhong et al, 2002). Among other plants, Rhizoma coptidis, Radix scutellariae and Radix salvia emiltiorrhizae are reported to be cold/cool-natured herbs (Liu et al, 2008) and are also used for treating hypertension as traditional Chinese medicines (Sanae et al, 2001;Kim et al, 2007;Tsai et al, 2008). Plants having a cold/cool-nature might exert a hypotensive effect.…”
Section: Discussionmentioning
confidence: 99%