Nitric oxide-dependent hypotensive effects of wax gourd juice

Nakashima, Miki; Shigekuni, Yukiko; Obi, Takeshi; Shiraishi, Masayuki; Miyamoto, Atsushi; Yamasaki, Hideo; Etoh, Takeomi; Iwai, Sumio

doi:10.1016/j.jep.2011.09.027

Cited by 16 publications

(10 citation statements)

References 15 publications

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“…The fruit juice (0.4 – 1.6 mL/kg, i.v.) dose-dependently lowered blood pressure, concentration-dependently showed relaxation of isolated rat aortic rings and produced nitric oxide (NO) from the cultured porcine aortic endothelial cells [ 116 ]. Polysaccharides of fruit extract showed an antiglycation effect [ 50 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Islam

Quispe

El‐Kersh

et al. 2021

Oxidative Medicine and Cellular Longevity

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Benincasa hispida (Thunb.) Cogn. (Cucurbitaceae) is an annual climbing plant, native to Asia with multiple therapeutic uses in traditional medicine. This updated review is aimed at discussing the ethnopharmacological, phytochemical, pharmacological properties, and molecular mechanisms highlighted in preclinical experimental studies and toxicological safety to evaluate the therapeutic potential of this genus. The literature from PubMed, Google Scholar, Elsevier, Springer, Science Direct, and database was analyzed using the basic keyword “Benincasa hispida.” Other searching strategies, including online resources, books, and journals, were used. The taxonomy of the plant has been made by consulting “The Plant List”. The results showed that B. hispida has been used in traditional medicine to treat neurological diseases, kidney disease, fever, and cough accompanied by thick mucus and to fight intestinal worms. The main bioactive compounds contained in Benincasa hispida have cytotoxic, anti-inflammatory, and anticancer properties. Further safety and efficacy investigations are needed to confirm these beneficial therapeutic effects and also future human clinical studies.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Islam

Quispe

El‐Kersh

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…To date, there is a trend to produce carbon-based materials from biomass, as it is cheap, easy to obtain, sustainable, and environmentally friendly. ,, Generally, biomass can be directly transformed into carbonous materials by a well-established hydrothermal carbonization (HTC) process under mild heating conditions. − The winter melon (wax gourd) is a fast growing and long season vegetable consumed widely in Asia and other semi-tropical countries. , This vegetable contains more than 90% water and less than 10% polysaccharide, making it a promising raw material for fabrication of highly porous structure materials. In this work, 3D carbon aerogels were made by a HTC and post-pyrolysis process using winter melon as the raw material.…”

Section: Introductionmentioning

confidence: 99%

“…20−24 The winter melon (wax gourd) is a fast growing and long season vegetable consumed widely in Asia and other semi-tropical countries. 25,26 This vegetable contains more than 90% water and less than 10% polysaccharide, making it a promising raw material for fabrication of highly porous structure materials. In this work, 3D carbon aerogels were made by a HTC and post-pyrolysis process using winter melon as the raw material.…”

Section: ■ Introductionmentioning

confidence: 99%

Carbon Aerogel from Winter Melon for Highly Efficient and Recyclable Oils and Organic Solvents Absorption

Samad

Polychronopoulou

et al. 2014

ACS Sustainable Chem. Eng.

307

165

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Direct conversion of biomass to carbon aerogel provides a promising approach to developing absorbent materials for spilled oils and organic solvents recovery. In this work, three-dimensional carbon aerogels were fabricated via a hydrothermal and post-pyrolysis process using winter melon as the only raw materials. The winter melon carbon aerogel (WCA) prepared shows a low density of 0.048 g/cm 3 , excellent hydrophobicity with a water contact angle of 135°, and selective absorption for organic solvents and oils. The absorption capacity of WCA for organic solvents and oils can be 16−50 times its own weight. Moreover, distillation can be employed to recover WCA and harvest the pollutants. Over five absorption−harvesting cycles, the absorption capacity of WCA to organic solvents and low boiling point oils can recover almost 100% of its starting capacity. With a combination of low-cost biomass as raw materials, green preparation process, low density, and excellent hydrophobicity, WCA as an absorber has great potential in application of spilled oil recovery and environmental protection.

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“…( Palamthodi and Lele, 2014 ; Sun et al, 2018 ). Various studies indicated that wax gourd had numerous therapeutic activities, including antihypertensive, antioxidant, anti-obesity, antiviral, anti-inflammatory and antitumor activities ( Huang et al, 2004 ; Kumar and Vimalavathini, 2004 ; Nakashima et al, 2011 ; Doshi et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

A time-course transcriptome analysis of wax gourd fruit development reveals predominant genes regulating taste and nutrition

Xue

Wan²,

Lu³

et al. 2022

Front. Plant Sci.

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Wax gourd, which belongs to Cucurbitaceae, is an excellent plant resource with the concomitant function of both medicine and foodstuff. Its unique taste and rich nutrition are deeply accepted by consumers. However, the main flavor and nutrients are still unclear, which restricts the quality breeding process of wax gourd. Here, we discovered that monosaccharides, malic acid and citrulline affect the flavor and nutrition of wax gourd and clarified the dynamic accumulation process of these metabolites. To gain insights into the underlying predominant genes regulating accumulation of these metabolites, we performed a time-course transcriptome analysis using RNA-sequencing analysis and compared the expression of screened genes among twenty-four germplasms with different metabolites levels. In addition, the expression abundance among the homologous genes were also analyzed. Finally, a total of 8 genes related to sugar [AGA2 (Bhi03G001926), SUS (Bhi12G001032)], malic acid [MDH (Bhi12G001426, Bhi01G000427), PEPC (Bhi12G000721, Bhi09G002867), ME (Bhi01G002616)] and citrulline [ASS (Bhi02G000401)], respectively were determined. In summary, understanding the core genes influencing taste or nutrition will provide a theoretical basis for fruit quality improvement in wax gourd.

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Nitric oxide-dependent hypotensive effects of wax gourd juice

Cited by 16 publications

References 15 publications

A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

A Literature‐Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles

Carbon Aerogel from Winter Melon for Highly Efficient and Recyclable Oils and Organic Solvents Absorption

A time-course transcriptome analysis of wax gourd fruit development reveals predominant genes regulating taste and nutrition

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