Effects of Scaling and Root Planing on Clinical Response and Serum Levels of Adipocytokines in Patients With Obesity and Chronic Periodontitis

Gonçalves, Tiago Eduardo Dias; Feres, Magda; Zimmermann, Gláucia Santos; Faveri, Marcelo; Figueiredo, Luciene Cristina; Braga, Paloma Gralha; Duarte, Poliana Mendes

doi:10.1902/jop.2014.140266

Cited by 42 publications

(84 citation statements)

References 29 publications

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“…There were significant changes in mild (≤3 mm) and moderate (4-6 mm) PPD and CAL in both groups, whereas severe (>6 mm) PPD and CAL did not exhibit significant improvement at any time-point in either group. These findings are consistent with those of recent studies, which reported persistent residual periodontal pockets of >6 mm, even after NSPT, in obese participants (27,39). These data suggest that obesity compromises periodontal healing, especially in deep periodontal pockets.…”

Section: Discussionsupporting

confidence: 93%

“…To our knowledge, this is the first randomized clinical trial that included a control group that did not receive any form of periodontal treatment (negative control), which allowed us to estimate the real magnitude of the effect of NSPT in obese CP patients. Previous studies compared the effects of periodontal treatment in obese and nonobese participants with CP and found improved clinical periodontal characteristics at follow-up in both groups after full-mouth scaling and root planing (19,(25)(26)(27)(28). In the present study, participants in the control group were assured that they would be given periodontal treatment at the end of the trial.…”

Section: Discussionmentioning

confidence: 66%

“…Several studies (23)(24)(25)(26)(27) have examined periodontal outcomes after nonsurgical periodontal treatment (NSPT) for CP in obese patients. Although some studies reported that obesity did not affect clinical attachment gain or probing pocket depth (PPD) reduction after periodontal treatment (25,26,28), other studies showed that patients with a higher body mass index (BMI) had a poorer response to NSPT (19,24).…”

Section: Introductionmentioning

confidence: 99%

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Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

et al. 2017

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This study investigated changes in periodontal outcomes after nonsurgical periodontal treatment (NSPT) and evaluated associations of change in salivary resistin level with periodontal outcomes in obese Malaysians with chronic periodontitis. Sixty-two obese adults with chronic periodontitis were randomly divided into a test group (n = 31), which received NSPT, and a control group (n = 31), which received no treatment. Plaque score (PS), gingival bleeding index (GBI), probing pocket depth (PPD), and clinical attachment loss (CAL) were measured at baseline and at 6 and 12 weeks after NSPT. Salivary resistin levels were evaluated by using an enzyme-linked immunosorbent assay. PS was significantly lower in patients who received NSPT than in the control group at 6 and 12 weeks (P < 0.05). In the NSPT group the percentages of sites with shallow and moderate pockets decreased significantly, but there was no significant change in deep pockets. Resistin levels significantly decreased after NSPT (P < 0.05). Change in salivary resistin level was not significantly associated with periodontal outcomes. In obese Malaysians, NSPT significantly improved PS and GBI, and improved PPD and CAL for shallow and moderately deep pockets but not for deep pockets. Salivary resistin level was not associated with improvement in either periodontal variable.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

et al. 2017

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“…This finding is in agreement with the results of Ongoz Dede et al and Duzagac et al (52,53). Gonçalves et al showed that reduced probing depth was lower in obese patients with CP compared with non-obese individuals with CP six months after SRP treatment; no difference was observed for three months (13,54).…”

Section: Discussionsupporting

confidence: 91%

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

et al. 2016

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The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-α. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-α (P < 0.008), which declined following treatment (P < 0.025), and lower omentin levels (P < 0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome. (J Oral Sci 58, [465][466][467][468][469][470][471][472][473] 2016)

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“…sig. )Gonçalves et al 2015 [31]Total number of patients:39Without obesity: 21With obesity: 18Age:Without obesity: 48.4(±9.5)With obesity: 48.8 (±5.9)p-value= 0.85 (n. sig.…”

Section: Methodsmentioning

confidence: 99%

Influence of obesity on the outcome of non-surgical periodontal therapy - a systematic review

et al. 2016

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Background: Obesity and periodontitis are important chronic health problems. Obesity is associated with an increased prevalence of periodontitis. Whether obesity also affects the outcome of non-surgical periodontal therapy is to date still unclear. Methods: A systematic review of studies referenced in SCOPUS, MEDLINE, PubMed, Cochrane, CINAHL, Biosis and Web of Science was performed. Titles, abstracts and finally full texts were scrutinized for possible inclusion by two independent investigators. Quality and heterogeneity of the studies were assessed and the study designs were examined. Probing pocket depth reduction was analyzed as primary surrogate parameter for therapeutic success after non-surgical periodontal therapy. Results: One-hundred-and-fifty-nine potentially qualifying studies were screened. Eight studies fulfilled the inclusion criteria and were analyzed. Three of eight studies failed to show an influence of obesity on pocket depth reduction after non-surgical therapy. The remaining five studies documented a clear negative effect on the outcome of non-surgical periodontal therapy. The finally included studies did not correspond to the highest level of quality (RCTs). Due to the heterogeneity of the data a meta-analysis was not possible. Conclusion:The literature on the effect of obesity on the treatment outcome of non-surgical periodontal therapy remains controversial. The data, however, support that obesity is not only a factor associated with poorer periodontal health but might also result in inferior response to non-surgical treatment of periodontitis.

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Effects of Scaling and Root Planing on Clinical Response and Serum Levels of Adipocytokines in Patients With Obesity and Chronic Periodontitis

Abstract: Patients with obesity and CP presented lower reductions in PD than patients without obesity with CP at 6 months after SRP. Furthermore, the treatment did not affect the circulating levels of leptin and adiponectin in any group.

Cited by 42 publications

References 29 publications

Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

Influence of obesity on the outcome of non-surgical periodontal therapy - a systematic review

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