Effects of Scirpusin B, A polyphenol in passion fruit seeds, on the coronary circulation of the isolated perfused rat heart

Matsumoto, Yutaka; Gotoh, Nozomi; Sano, Shoko; Sugiyama, Kenkichi; Ito, Tatsuhiko; Abe, Yohei; Katano, Yumi; Ishihata, Akira

doi:10.5958/2319-5886.2014.00394.4

Cited by 7 publications

(5 citation statements)

References 38 publications

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“…These results suggest that PFSE treatment improved the systolic cardiac function. Therefore, PFSE may effectively improve cardiovascular functions both ex vivo 10,12 and in vivo. However, additional experiments like histological analysis will be needed to indicate cardioprotective effects.…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported that piceatannol and its dimer, scirpusin B, are present in large amounts in passion fruit seeds. 9,10 In addition, they have a wide range of biological activities including increasing eNOS expression, endotheliumdependent vasorelaxation, and coronary blood flow, [10][11][12][13][14][15] similar to resveratrol. Interestingly, piceatannol is more highly absorbed in its intact form 16 and shows higher eNOS expression 11 and stronger anti-inflammation activities 5 than resveratrol does.…”

Section: Introductionmentioning

confidence: 99%

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Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats

et al. 2016

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The effects of chronic administration of piceatannol-enriched (9.5% w/w) passion fruit seed extract (PFSE) on the cardiovascular damage induced in a high-fat (HF) diet-fed model of Fischer 344 rats were evaluated. Rats were fed the control, HF, or HF diets containing PFSE (0.5% w/w) for 16 weeks, and the effects of the various diets on the tissue weight, serum lipid profile, hepatic fibrosis, hepatic ductular reaction, cardiac function and aortic ring reactivity were examined. HF diet-fed rats developed signs of cardiovascular disease with abnormal serum profiles compared to control diet-fed rats. PFSE supplementation improved the liver hypertrophy and hepatic histology of the HF diet-fed rats. In addition, the triglyceride and cholesterol levels, platelet aggregation, cardiac function, and acetylcholine-mediated relaxation of the aortic ring were improved. These results suggest that the chronic intake of PFSE containing piceatannol prevents HF diet-induced cardiovascular disease in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats

et al. 2016

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“…The passion fruit seed contains fatty acids, sterols, triglycerides, and tocopherols, [8] as well as a high concentration of various stilbenoids such as trans-piceatannol, [11] trans-resveratrol, cassigarol E, [8] scirpusin A, and scirpusin B. [12] It has been reported that trans-piceatannol and cassigarol E possess potent inhibitory activity on soluble epoxide hydrolase (sEH). [9] trans-resveratrol, a well-known stilbene derived from grape seed, and trans-piceatannol, the main components of passion seed, are the most studied stilbenoids, and they possess valuable biological activities relating to Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

“…6–12 % of the fruit's weight was comprised of seeds, which are by‐products of the juice industry and potential resources for pharmaceutical applications. The passion fruit seed contains fatty acids, sterols, triglycerides, and tocopherols, [8] as well as a high concentration of various stilbenoids such as trans‐ piceatannol, [11] trans‐ resveratrol, cassigarol E, [8] scirpusin A, and scirpusin B [12] . It has been reported that trans‐ piceatannol and cassigarol E possess potent inhibitory activity on soluble epoxide hydrolase (sEH) [9] …”

Section: Introductionmentioning

confidence: 99%

Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies

Mostefa

Djebli

Khanh

et al. 2023

Chemistry & Biodiversity

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The stilbene-rich acetone fraction in high yield (6.6 %, PEAS) of Passiflora edulis Sims was prepared and evaluated for neuroprotective activity in murine Alzheimer's disease model induced by aluminum chloride and D-galactose. The phytochemical and HPLC-DAD-MS analysis of the polyphenolic stilbene-rich acetone fraction showed that it contained different stilbenes including trans-piceatannol, scirpusins AÀ B and cassigarol E. The total phenolic content (TPC) of PEAS was 413.87 � 1.71 mg GAE eqv/g. The neuroprotective activity of PEAS is typically presented in the Morris water maze-reference Spatial Memory test, where the Alzheimer's mice treated at 100 mg/kg (Alz-ED1) and 200 mg/kg (Alz-ED2) spent less than 47 % and 66 % of the time, respectively, than the Alzheimer's model mice (Alz). Two simple stilbenes, trans-piceatannol and trans-resveratrol, showed selectively inhibitory activity in silico against acetylcholinesterase (AChE). Two stilbene dimers, cassigarol E and scirpusin A, exhibited low nanomolar inhibitory potential against AChE and butyrylcholinesterase (BChE), significantly lower than those of the positive control, donepezil and tacrine. These findings suggest that the stilbenes from P. edulis seeds, particularly the stilbene dimers, warrant further investigation as potential neuroprotective candidates in the prevention of cognitive deficits associated with Alzheimer's disease.

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“…Sano et al [21], apart from these two substances, found another phenolic compound known as Scirpusin B (Figure 2), but the authors quantified only piceatannol and Scirpusin B, which amounts were 5.7 and 3.6 mg/g of dried seed, respectively. Matsumoto et al [22] used Scirpusin B for the evaluation of the coronary circulation of rats and found that this compound caused the increase in coronary blood flow via production of nitric oxide and vasodilating prostanoids. Scirpusin B is implicated to have beneficial effects on preventing cardiac events and atherosclerosis by increasing these substances responsible for vasodilatation.…”

Section: Bagassementioning

confidence: 99%

Trends for the Application of Passion Fruit Industrial By-products: A Review on the Chemical Composition and Extraction Techniques of Phytochemicals

Viganó¹,

Martínez²

2015

fph

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This work presents a review on the composition and extraction techniques for recovering phytochemicals from passion fruit by-products. The review approaches on the characteristics of each phytochemical and its benefits to human health. It was observed that the by-products of passion fruit contain a range of interesting substances, and for their recovery the application of environmentally friendly extraction techniques, such as supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE), are suggested as single or sequential procedures. The future perspectives of this review encourage the application of these techniques to a complete recovery of passion fruit by-products.

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Effects of Scirpusin B, A polyphenol in passion fruit seeds, on the coronary circulation of the isolated perfused rat heart

Cited by 7 publications

References 38 publications

Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats

Vascular- and hepato-protective effects of passion fruit seed extract containing piceatannol in chronic high-fat diet-fed rats

Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies

Trends for the Application of Passion Fruit Industrial By-products: A Review on the Chemical Composition and Extraction Techniques of Phytochemicals

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