Effects of L‐ascorbic acid 2‐phosphate magnesium salt on the properties of human gingival fibroblasts

Abstract

These results suggest that APM is more effective than AsANa in terms of intake, collagen synthesis, decreasing cell damage and inhibiting interleukin-8 expression in human gingival fibroblasts. This suggests that local application of APM can help to prevent periodontal disease.

Decreased expression of E‐cadherin by Porphyromonas gingivalis‐lipopolysaccharide attenuates epithelial barrier function

“…In addition, Tsutsumi et al . reported that APM was more effective in terms of intake and suppressive effect on intracellular ROS in human gingival fibroblasts. These results suggest that the poor permeability of VC into epi‐4 cells is the cause of VC ineffectiveness.…”

Relationship among salivary antioxidant activity, cytokines, and periodontitis: the Nagasaki Island study

“…Recently, total levels of ROS or antioxidant activity were determined using fluorescence analysis (Tsutsumi et al. ), chemiluminescence (Ginsburg et al. ), and absorptiometry (Tamaki et al.…”

“…Subjects with worse periodontal condition tended to have increased oxidative injury to periodontal tissue. Recently, total levels of ROS or antioxidant activity were determined using fluorescence analysis (Tsutsumi et al 2012), chemiluminescence (Ginsburg et al 2013), and absorptiometry (Tamaki et al 2011). However, these analyses quantify antioxidant activities against nonspecific ROS.…”

Evaluation of Collagen Type-1 Production and Anti-Inflammatory Activities of Human Placental Extracts in Human Gingival Fibroblasts

“…In addition, Melsmon contains a variety of vitamins, which improve the production capabilities of collagen in HGFs 27) . When considering these points, we believe that the growth factors and vitamins in Melsmon can probably act to improve the collagen production by HGFs.…”