Effects of Scutellaria baicalensis Georgi. on intestinal flora in rats with spleen deficiency and damp-heat

Wang, Yizhu; Cai, Yongyu; Li, Fangtong; Zhang, Meiyu; Wu, Yongxi; Dai, Yulin; Zheng, Fei; Yue, Hao; Bai, Bing

doi:10.1016/j.jpba.2022.114831

Cited by 12 publications

(7 citation statements)

References 21 publications

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“…Previous reports have shown that fermentation can effectively increase the content of flavonoids and improve the biological activities of herbs, such as anti‐inflammatory activity and immune enhancement 50,51 . In addition, flavonoids, as non‐polysaccharide components, had a significant effect on the composition of the gut microbiota 52 . Extraction of flavonoids from ginseng to study the effect on the intestinal microbiota of SDS rats showed that flavonoids significantly increased the relative abundance of SDS rats with Firmicutes and Bacteroidetes at the phylum level, decreased the abundance of Escherichia – Shigella at the genus level and reversed the dysregulation of the intestinal microbiota in SDS rats 53 .…”

Section: Discussionmentioning

confidence: 98%

“…50,51 In addition, flavonoids, as non-polysaccharide components, had a significant effect on the composition of the gut microbiota. 52 Extraction of flavonoids from ginseng to study the effect on the intestinal microbiota of SDS rats showed that flavonoids significantly increased the relative abundance of SDS rats with Firmicutes and Bacteroidetes at the phylum level, decreased the abundance of Escherichia-Shigella at the genus level and reversed the dysregulation of the intestinal microbiota in SDS rats. 53 In our study, fermentation significantly increased the flavonoid content of QD and might accurately regulate the abundance of probiotic bacteria such as Bifidobacterium and Faecalibacterium, as well as pathogenic bacteria such as Escherichia-Shigella.…”

Section: Discussionmentioning

confidence: 99%

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Probiotic‐fermented Qushi decoction alleviates reserpine‐induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis

et al. 2023

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BACKGROUNDSpleen deficiency syndrome (SDS) is associated with elevated inflammatory factors and dysregulation of gastrointestinal motility hormones and intestinal microbiota. Qushi decoction (QD), a traditional formula, has not been reported using modern scientific research methods for changes in its probiotic fermented QD (FQD) composition and its potential mechanisms to alleviate SDS. Therefore, the aim of this study was to investigate the splenic protection of FQD in SDS rats by modulating gastrointestinal motility hormones and intestinal microbiota.RESULTSThe results showed that FQD increased total polysaccharides, total protein, total flavonoids and the other active ingredients compared to QD, effectively improved splenic inflammation and apoptosis in SDS rats, and modulated gastrointestinal motility hormones to alleviate diarrhea and other symptoms. In addition, the dysregulation of the gut microbiota was reversed by increasing the levels of Bifidobacterium and decreasing the levels of Escherichia–Shigella and Proteobacteria, which may be related to the regulation of bacterial metabolites to alleviate SDS.CONCLUSIONThese results suggest that FQD is an effective formula for improving SDS. Our findings show that FQD beneficial to the implications for the treatment of SDS. © 2023 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Probiotic‐fermented Qushi decoction alleviates reserpine‐induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis

et al. 2023

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“…This medicinal effect is due to its antioxidant [ 44 ], antibacterial [ 45 ], and anti-inflammatory properties [ 43 , 44 ], and its protective ability against gastrointestinal diseases via the opsonization of intestinal commensal bacteria, as well as its ability to alleviate epithelial injury and inflammation [ 39 ]. Scutellaria baicalensis Georgi (“huangqin” in Chinese) is also an old and well-known component of TCM and is widely used for the treatment of bronchitis, hepatitis, tumors, and inflammatory diseases [ 46 , 47 , 48 , 49 , 50 ]. Numerous research studies have indicated that the therapeutic effects of Scutellaria baicalensis Georgi are due to its various pharmacological activities, including its antiangiogenic, anti-inflammatory, antimicrobial, immunoenhancing, and antioxidative effects [ 51 , 52 , 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Fructus mume and Scutellaria baicalensis Georgi on the Fecal Microbiota and Its Correlation with Apparent Nutrient Digestibility in Weaned Piglets

Zhang

Jin

Liu

et al. 2022

Animals

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Traditional Chinese medicine (TCM) has long been demonstrated to exert a therapeutic effect on various diseases and has been used as a substitute for antibiotics in pig production. However, few studies have investigated the relationship between the intestinal microbiota and apparent nutrient digestibility when weaned piglet diets are supplemented with TCM. One hundred and sixty-two 25-day-old weaning piglets were housed in an environmentally controlled nursery facility and fed a basal diet (control group, n = 54) or a TCM complex (Fructus mume 1%, Scutellaria baicalensis Georgi 3%) (TCM group, n = 54), or a fermented diet with a complex of these two TCMs (F-TCM group, n = 54). Compared with the control group, in the TCM and F-TCM groups, the average daily gain (ADG) increased (p < 0.05), the F:G ratio and diarrhea rate decreased (p < 0.05), and the apparent digestibility of dry matter (DM) and ether extract (EE) of weaned piglets increased (p < 0.05). Bacteroidetes and Firmicutes were the predominant phyla, representing approximately 95% of all sequences. The abundance of four genera and 10 OTUs (belonging to Ruminococcaceae_UCG-014, Lachnoclostridium, Prevotellaceae_NK3B31 group, Prevotella_1) were negatively correlated with apparent EE digestibility (p < 0.05). The results suggest that weaned piglets fed with antibiotic-free diets supplemented with Fructus mume and Scutellaria baicalensis Georgi gained more weight and were healthier. When added to the diet, the complex of these two TCMs may have a direct impact on apparent EE digestibility by modifying the gut microbial composition, which favors the health of weaned piglets.

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“…When spleen deficiency syndrome occurs in the body, species richness and quantity of gut microbiota will be significantly affected 6,7 . Pathogenic bacteria such as Escherichia coli , Streptococcus , Clostridium difficile , and Staphylococcus will proliferate in large numbers, while probiotics such as Bifidobacteria , Lactobacillus , and Bacteroides will decrease significantly 8,9 . Short‐chain fatty acids (SCFAs), such as acetic acid, propionic acid, and butyric acid, are a class of fatty acids characterized by short carbon chains of less than eight atoms 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…Clostridium difficile, and Staphylococcus will proliferate in large numbers, while probiotics such as Bifidobacteria, Lactobacillus, and Bacteroides will decrease significantly. 8,9 Short-chain fatty acids (SCFAs), such as acetic acid, propionic acid, and butyric acid, are a class of fatty acids characterized by short carbon chains of less than eight atoms. 10,11 These beneficial metabolites result from the fermentation of undigested carbohydrates by intestinal commensal bacteria, and their impact on the host immune system is far-reaching.…”

mentioning

confidence: 99%

Effects of ginseng on short‐chain fatty acids and intestinal microbiota in rats with spleen‐qi deficiency based on gas chromatography–mass spectrometry and 16s rRNA technology

Zhang,

Pi,

et al. 2023

Rapid Comm Mass Spectrometry

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RationaleSpleen‐qi deficiency syndrome, a common weakness syndrome in traditional Chinese medicine, results from insufficient spleen‐qi levels. For centuries, ginseng has been relied upon as a traditional Chinese medicine to treat spleen‐qi deficiency syndrome. Until now, the mechanism feature of ginseng in treating temper deficiency through intestinal bacteria and short‐chain fatty acid (SCFA) metabolites has not been fully elucidated.MethodsThis study established a rat model of spleen‐qi deficiency via multi‐factor compound modeling that involved fatigue injury and a controlled diet. The content of SCFAs between different treatment groups was determined by gas chromatography–mass spectrometry. And the 16s rRNA sequencing technology was applied to reveal the effects of ginseng on the intestinal microecological environment of the rats.ResultsIt was found that the ginseng treatment group exhibited the most remarkable regulatory effect on propionic acid, surpassing all other administration groups. Ginseng increased the relative abundance of beneficial bacteria and decreased that of harmful bacteria at the genus level in rats with spleen‐qi deficiency syndrome. And propionic acid is significantly positively correlated with Lactobacillus level and significantly negatively correlated with uncultured_bacterium_f_Muribaculaceae (p < 0.05). n‐Butyric acid is negatively correlated with the Faecalibaculum level (p < 0.01). n‐Valeric acid is significantly negatively correlated with the Romboutsia level (p < 0.01).ConclusionThe mechanism of ginseng treatment for spleen‐qi deficiency is elucidated from the perspective of gut microbiota and its metabolite SCFAs. It provides a new way for further development and utilization of ginseng and a theoretical basis.

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Effects of Scutellaria baicalensis Georgi. on intestinal flora in rats with spleen deficiency and damp-heat

Cited by 12 publications

References 21 publications

Probiotic‐fermented Qushi decoction alleviates reserpine‐induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis

Probiotic‐fermented Qushi decoction alleviates reserpine‐induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis

Effect of Dietary Fructus mume and Scutellaria baicalensis Georgi on the Fecal Microbiota and Its Correlation with Apparent Nutrient Digestibility in Weaned Piglets

Effects of ginseng on short‐chain fatty acids and intestinal microbiota in rats with spleen‐qi deficiency based on gas chromatography–mass spectrometry and 16s rRNA technology

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