Effects of secondhand smoke exposure on asthma morbidity and health care utilization in children: a systematic review and meta-analysis

Wang, Zhen; May, Sara M.; Charoenlap, Suvanee; Pyle, Regan; Ott, Nancy L.; Mohammed, Khaled; Joshi, Avni Y.

doi:10.1016/j.anai.2015.08.005

Cited by 140 publications

(84 citation statements)

References 51 publications

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“…Further, maternal smoking in the first year of a child’s life was associated with a greater risk of all asthma symptoms at 13–14 years, highlighting the impact of early exposure on long-term respiratory outcome [3]. ETS exposure has also been associated with more severe asthma attacks; children with asthma and ETS exposure were twice as likely to be hospitalized for asthma and had more emergency unit visits (OR 1.66, 95% CI 1.02–2.69) than unexposed asthmatics [56]. A 20% increased length of hospital stay was also found in ETS-exposed asthmatic children [57].…”

Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

151

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Introduction: Childhood respiratory illness is a major cause of morbidity and mortality particularly in low and middle-income countries. Environmental tobacco smoke (ETS) exposure is a recognised risk factor for both acute and chronic respiratory illness.Areas covered: The aim of this paper was to review the epidemiology of ETS exposure and impact on respiratory health in children. We conducted a search of 3 electronic databases of publications on ETS and childhood respiratory illness from 1990–2015. Key findings were that up to 70% of children are exposed to ETS globally, but under-reporting may mask the true prevalence. Maternal smoking and ETS exposure influence infant lung development and are associated with childhood upper and lower respiratory tract infection, wheezing or asthma. Further, exposure to ETS is associated with more severe respiratory disease. ETS exposure reduces lung function early in life, establishing an increased lifelong risk of poor lung health.Expert commentary: Urgent and effective strategies are needed to decrease ETS exposure in young children to improve child and long-term lung health in adults especially in low and middle income countries where ETS exposure is increasing.

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Section: Resultsmentioning

confidence: 99%

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Vanker

Gie

Zar

2017

Expert Review of Respiratory Medicine

151

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“…Rapid, forced or labored breathing, as well as retraction below the ribs or use of accessory muscles for breathing indicate severe respiratory distress and possible impairment of the lower airways. Studies have shown that asthma and bronchitis are associated with secondhand smoke in children, and that secondhand smoke children have an almost twice as high chance of presenting these respiratory problems (4,(7)(8)18) . The results of this study suggest that secondhand smoking in the home is also associated with the occurrence of treated ear disease in preschool children, corroborating previous studies (25)(26) .…”

Section: Discussionmentioning

confidence: 99%

“…In 2011, respiratory system diseases represented the second leading cause of deaths in Brazil, with pneumonia being the cause for 35.6% of hospitalizations in children under the age of 5 years (6) . Evidence suggests that secondhand smoke in childhood increases the chances of hospitalization due to asthma, the demand for emergency services (7) , wheezing attacks (8) , rhinitis symptoms (9) , food sensitization (10) , caries/cavities in primary dentition (11) , atrial fibrillation (12) , behavioral problems (13) , lower engagement in school activities (14) and lower weight and height gain (15) . However, there is a lack of national studies that verify the association between secondhand smoking and respiratory symptoms easily noticeable by family members in preschool children, such as coughing, rapid breathing, "wheezing" and signs of respiratory distress, such as retraction below the ribs.…”

Section: Introductionmentioning

confidence: 99%

Association between secondhand smoking in the home and respiratory morbidity in preschool children

Sigaud

Castanheira

Costa

2016

Rev. esc. enferm. USP

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Objective: Identifying the prevalence of secondhand smoking in the home and its association with morbidity and hospitalization from respiratory causes in preschool children. Method: This is a cross-sectional study conducted in five early childhood education centers at a public university in São Paulo. Sample size calculation was performed and the participants were randomly determined. Data were collected through questionnaires completed by family members or caregivers of 215 children. Chi-square and Student's t-test were used for the statistical analysis, using a 0.05 significance level. Results: The prevalence of secondhand smoke in the household was 15.3%. Bivariate analysis revealed that secondhand smoke in the household was associated with the occurrence of rapid breathing, subdiaphragmatic retractions in the past three months, and treated ear infections/otitis. Conclusion: A low prevalence of secondhand smoking in the home was found. Secondhand smoke was associated with a higher prevalence of respiratory symptoms and morbidity. DESCRIPTORS

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“…CS and air pollution were found to enhance the risk for developing asthma (Ferrante et al 2014) and are thought to trigger acute exacerbations in patients with established asthma (Guarnieri and Balmes 2014;Wang et al 2015). Moreover, occupational respiratory exposures, such as toluene diisocyanate and possibly nanoparticles, are etiological factors for the development of occupational asthma (Sharma 2010;Tarlo and Lemiere 2014).…”

Section: Asthma and Occupational Asthmamentioning

confidence: 99%

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

Benedikter

Wouters

Savelkoul

et al. 2018

Journal of Toxicology and Environmental Health, Part B

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Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to respiratory exposure-associated diseases. Publications were searched using PubMed and Google Scholar with the search terms (cigarette smoke OR tobacco smoke OR air pollution OR particulate matter) AND (extracellular vesicles OR exosomes OR microvesicles OR microparticles OR ectosomes). All original research articles were included and reviewed. Fifty articles were identified, most of which investigated the effect of respiratory exposures on EV release in vitro (25) and/or on circulating EV in human plasma (24). The majority of studies based their main observations on the relatively insensitive scatter-based flow cytometry of EV (29). EV induced by respiratory exposures were found to modulate inflammation (19), thrombosis (13), endothelial dysfunction (11), tissue remodeling (6), and angiogenesis (3). By influencing these processes, EV may play a key role in the development of cardiovascular diseases and chronic obstructive pulmonary disease and possibly lung cancer and allergic asthma. The current findings warrant additional research with improved methodologies to evaluate the contribution of respiratory exposure-induced EV to disease etiology, as well as their potential as biomarkers of exposure or risk and as novel targets for preventive or therapeutic strategies.

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Effects of secondhand smoke exposure on asthma morbidity and health care utilization in children: a systematic review and meta-analysis

Abstract: Children with asthma and SHS exposure are nearly twice as likely to be hospitalized with asthma exacerbation and are more likely to have lower pulmonary function test results.

Cited by 140 publications

References 51 publications

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

The association between environmental tobacco smoke exposure and childhood respiratory disease: a review

Association between secondhand smoking in the home and respiratory morbidity in preschool children

Extracellular vesicles released in response to respiratory exposures: implications for chronic disease

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