Effects of Secretin and Cholecystokinin on Motor Activity of Human Jejunum

Dollinger, H. C.; Berz, R.; Raptis, Sotirios A.; Uexküll, Thure von; Goebell, H.

doi:10.1159/000197648

Cited by 15 publications

(2 citation statements)

References 15 publications

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“…More thorough mixing probably results, while transit of content through the small bowel is definitely speeded [52]. CCK augments motility in the entire small bowel [51,53,54], except for one region. The exception is the region adjacent to the sphincter of Oddi, where CCK relaxes the smooth muscle [55].…”

Section: Small Intestinementioning

confidence: 99%

“…In contrast to gastrin, CCK, motilin, and VIP, secretin reduces the incidence of action potentials and contractions in the small bowel without significantly affecting the frequency or velocity of the small intestinal pacesetter potentials [45,47,64,65]. The inhibition of action potentials is greater in the duodenum and jejunum than in the ileum [64], and both Type I and Type III contractions are inhibited [45,47,53,54]. Secretin also inhibits CCK-induced contractions as well as spontaneous contractions, although the secretin-induced inhibition can be overcome by large doses of CCK [51].…”

Section: Small Intestinementioning

confidence: 99%

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Hormonal control of gastrointestinal motility

1979

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The objective of these studies was to assess the role of gastrointestinal hormones in controlling gastrointestinal motility. In the proximal stomach, cholecystokinin (CCK), gastrin, and secretin inhibit contractions, thereby decreasing intragastric pressure and slowing gastric emptying of liquids. Gastric inhibitory polypeptide (GIP), glucagon, and vasoactive intestinal peptide (VIP) may also slow gastric emptying, since they also inhibit proximal gastric contractions, but this was not tested. In contrast, motilin augments proximal gastric contractions and speeds gastric emptying of liquids. The contractions of the distal stomach are stimulated by gastrin, CCK, and motilin and inhibited by secretin, gastric inhibitory polypeptide, and VIP. The modulation of distal gastric contractions by these hormones may influence gastric trituration and emptying of solids, but this is unknown. Pyloric contractions are enhanced by CCK and secretin, an effect blocked by gastrin. Such enhancement ought to decrease duodenal‐gastric reflux, but again, this is untested. In the small bowel, CCK, gastrin, motilin, VIP, and glucagon stimulate contractions, while secretin inhibits contractions. CCK and motilin speed small bowel transit, but VIP and glucagon slow transit. The cyclical bursts of gastroduodenal contractions that occur during fasting are associated with increased concentrations of motilin in the plasma, whereas the contractions characteristic of the fed state are copied by exogenous administration of gastrin and CCK. Of all these actions, only those of CCK on the proximal stomach, and gastrin on the distal stomach, have been shown to be physiologic so far.

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Section: Small Intestinementioning

confidence: 99%

Section: Small Intestinementioning

confidence: 99%

Hormonal control of gastrointestinal motility

1979

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Gastrointestinal Nerves, Hormones and Autacoids in Relation to Human Gastrointestinal Motility

Bennett

1984

Mechanisms of Gastrointestinal Motility and Secretion

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Effects of secretin and cholecystokinin-pancreocymin on water, electrolyte and glucose absorption in human jejunum

et al. 1982

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The effects of natural secretin (90%) and synthetic secretin as well as impure (10%) and pure (99%) cholecystokinin-pancreozymin (CCK) on net absorption of water, electrolytes, and glucose in human jejunum were studied in 31 normal subjects. An intestinal perfusion technique with a triple-lumen tube was used. Net absorption of water and solute was significantly inhibited by both hormones only with larger doses, pure CCK being less active than impure CCK. A dose-dependent response of water and electrolyte absorption to graded doses of pure CCK was observed, without concomitant inhibition of glucose absorption with lower doses. The findings suggest that secretin and CCK may not be of physiologic importance regarding intestinal absorption in man. The definite changes in intestinal motility and transit rate caused by these hormones seem more likely to result in a reduction of intestinal absorption and an increase in the secretion of water and electrolytes along the proximal small bowel.

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Effects of Secretin and Cholecystokinin on Motor Activity of Human Jejunum

Cited by 15 publications

References 15 publications

Hormonal control of gastrointestinal motility

Hormonal control of gastrointestinal motility

Gastrointestinal Nerves, Hormones and Autacoids in Relation to Human Gastrointestinal Motility

Effects of secretin and cholecystokinin-pancreocymin on water, electrolyte and glucose absorption in human jejunum

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