Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats

Alizadeh-Fanalou, Shahin; Babaei, Mohammad; Hosseini, Asieh; Azadi, Nammam Ali; Nazarizadeh, Ali; Shojaii, Asie; Borji, Mohammad; Malekinejad, Hassan; Bahreini, Elham

doi:10.1016/j.jep.2019.112331

Cited by 17 publications

(34 citation statements)

References 48 publications

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“…S. securidaca, like other plants, contains a wellknown and unknown set of compounds that may have positive or negative side effects. In our previous study, antidiabetic and antioxidant properties of hydroalcoholic seed extract of S. securidaca were evaluated in streptozotocin-induced diabetic rats, and the results were compared with the effects of the standard drug of glibenclamide, alone and in combination with HESS (8). We experienced that HESS reduced blood sugar and insulin resistance dose-dependently, and the effect was enhanced when used in combination with glibenclamide.…”

Section: Discussionmentioning

confidence: 99%

“…In a chain study, we examine the positive or negative side effects of S. securidaca on diabetes complications. Our previous experiment showed that the herbal extract as a supplement could improve the hypoglycemic, antioxidant, and anti-in ammatory properties of the standard drug (8). In this short report, the possible effect of S. securidaca seeds on neovascularization was evaluated in the diabetic animal model, alone and in combination with glibenclamide.…”

Section: Introductionmentioning

confidence: 94%

“…As mentioned, the current study is a continuation of our previous studies on the side effects of S. securidaca seed by predicting its potential to prevent angiogenesis. S. securidaca seed (herbarium code of PMP-756) extraction and determination of total phenolic and avonoid contents have been described in detail in our previous publication (8). Brie y, the ground seed was extracted with 70% ethanol and concentrated by rotary evaporation.…”

Section: Seed Extract Preparation and Determination Of Total Phenolicmentioning

confidence: 99%

“…In addition to hypoxia and ROS, HIF-1α expression can be induced by numerous other factors, including nitric oxide (NO), in ammatory cytokines such as TNF-α, pro-in ammatory factors such as hormone-like growth factors such as TGF-β (5). As reported by some researches (6,7), HIF-1α expression may also be reduced by FGF21, a multifunctional factor with the protective effects on diabetic complications and energy hemostasis (8). VEGF is also up-regulated upon stimulation of such factors.…”

Section: Introductionmentioning

confidence: 99%

“…Securigera securidaca (L.) Degen & Dor (S. securidaca), with local names of Adasol-molk and Bitterlentils, belongs to the Fabaceae family. The seed of the plant is used in Iranian folk medicine and also by Egyptians and Indians since ancient times to treat several ailments such as diabetes, hyperlipidemia, and hypertension (8,16,17). In a chain study, we examine the positive or negative side effects of S. securidaca on diabetes complications.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Securigera Securidaca Seed Extract, Alone and in combination with Glibenclamide, on Circulating Levels of Pro-Angiogenic/Anti-Angiogenic Biomarkers in Hyperglycemic Rats

Alizadeh-Fanalou

Babaei

Bahreini

2020

Preprint

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Background: Many diabetic patients use herbal medicines in addition to their mainstream treatments. Plants contain a well-known and unknown set of compounds that may exacerbate or improve diabetes complications. Thus, the side effects of these herbs should be known before prescribing. The aim of the study is to investigate the effects of hydroalcoholic extract of Securigera securidaca (L.) Degen & Dorfl (S. securidaca) seed (HESS) on angiogenesis/anti-angiogenesis balance in Streptozotocin (STZ)-induced diabetic rats, alone and in combination with glibenclamide. Methods: The groups involved in this animal study included diabetic and healthy control groups, groups treated with three doses of HESS, group treated with glibenclamide, and groups received combination therapy. Serum samples were taken and analyzed for the levels of angiogenic/ anti-angiogenic biomarkers.Results: Induction of diabetes increased serum levels of angiogenic agents and decreased circulating anti-angiogenic factors. The herbal extract, even with the highest dose, had little effects on the blood levels of the tested biomarkers except with TGF-β. Glibenclamide was more effective than the highest dose of HESS in preventing the increase in serum levels of angiogenic factors and in inhibiting the decrease in anti-angiogenic agents in diabetic rats. Combination therapy with the highest dose of HESS partly enhanced the glibenclamide effects.Conclusions: Although glibenclamide was more effective than the highest dose of HESS used in this study in preventing changes in serum concentrations of angiogenic/ anti-angiogenic biomarkers in the diabetic animals, this study show that S. securidaca has no side effects on diabetes complications caused by vascular disorders and neovascularization, and still it can be used as a herbal supplement with the standard drug.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Seed Extract Preparation and Determination Of Total Phenolicmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Securigera Securidaca Seed Extract, Alone and in combination with Glibenclamide, on Circulating Levels of Pro-Angiogenic/Anti-Angiogenic Biomarkers in Hyperglycemic Rats

Alizadeh-Fanalou

Babaei

Bahreini

2020

Preprint

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Enhanced Insulin Secretion Through Upregulation of Transcription Factors by Hydroalcoholic Extract of Securigera securidaca Seeds in Diabetic Animal Model

Hasani,

Abbasi‐Oshaghi,

Khomari

et al. 2024

Endocrino Diabet & Metabol

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AimIn previous studies, the researchers observed an increase in insulin secretion in STZ‐treated diabetic rats following treatment with the hydroalcoholic extract of Securigera securidaca (HESS) seeds. This study focuses on the relationship between the antioxidant properties of HESS with changes in diabetic pancreatic tissue and the gene expression of factors that impact insulin secretion.MethodsIn this controlled experimental study, three varying doses of HESS were administered to three groups of diabetic rats induced by STZ. Oxidative stress indicators like total antioxidant capacity (TAC), total oxidant status (TOS) and malondialdehyde were assessed in both pancreatic and liver tissues. Pancreatic histology was studied post‐haematoxylin staining. Insulin and FGF21 levels in the blood were measured using the ELISA method. The expression of Nrf2 and FGF21 genes in the pancreas and liver, along with MafA and PDX‐1 genes in the pancreas, was quantified using real‐time PCR.ResultsThe administration of HESS in varying doses led to a dose‐dependent rise in blood insulin levels and a decrease in blood glucose levels and oxidative stress. By reducing oxidative stress, HESS treatment lowered the heightened levels of NRF2 and FGF21 in the liver and pancreas of diabetic rats, improving pancreatic tissue health. As oxidative stress decreased, the expression of MafA and PDX1 genes in the pancreas approached levels seen in healthy rats.ConclusionHESS elicits an increase in insulin secretion through the mitigation of oxidative stress and tissue damage, as well as the modulation of gene expression related to the insulin transcription factors PDX‐1 and MafA.

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Plant extracts as natural modulators of gut microbiota community structure and functionality

Pérez-Burillo

Hinojosa-Nogueira

Pastoriza

et al. 2020

Heliyon

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The main objective of this work was to evaluate the effect that several plant extracts (currently sold as functional ingredients) have on gut microbiota community structure and functionality. Plant extracts were submitted to an in vitro digestion and fecal fermentation. Overall, plant extracts showed a marked inhibitory activity when compared to basal conditions. However, they also favored the growth of some bacteria such as Coprococcus and Butyricimonas, two butyrate producers. Especially interesting was tea extract which inhibited the growth of the genus Escherichia/Shigella, known to involve species related with gastrointestinal disorders. Additionally, tea extract increased the growth of Faecalibacterium, a known butyrate producer. Regarding short chain fatty acids production, while plant extracts reduced acetate production, butyrate was increased for most samples, especially tea extract. Propionate production was less affected in comparison with basal conditions. Fermentation by gut microbiota also modified the antioxidant capacity (assessed via DPPH, FRAP and Folin-Ciocalteu methods).

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Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats

Cited by 17 publications

References 48 publications

Effects of Securigera Securidaca Seed Extract, Alone and in combination with Glibenclamide, on Circulating Levels of Pro-Angiogenic/Anti-Angiogenic Biomarkers in Hyperglycemic Rats

Effects of Securigera Securidaca Seed Extract, Alone and in combination with Glibenclamide, on Circulating Levels of Pro-Angiogenic/Anti-Angiogenic Biomarkers in Hyperglycemic Rats

Enhanced Insulin Secretion Through Upregulation of Transcription Factors by Hydroalcoholic Extract of Securigera securidaca Seeds in Diabetic Animal Model

Plant extracts as natural modulators of gut microbiota community structure and functionality

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