Effects of self-assembly of 3-phosphonopropionic acid, 3-aminopropyltrimethoxysilane and dopamine on the corrosion behaviors and biocompatibility of a magnesium alloy

Biodegradable Mg/HA/TiO2 Nanocomposites Coated with MgO and Si/MgO for Orthopedic Applications: A Study on the Corrosion, Surface Characterization, and Biocompatability

“…The long-term in vitro degradation behavior of samples was examined to measure hydrogen evolution during the immersion of samples in SBF solution for different times. Hydrogen evolution is usually measured as an indicator of the magnesium degradation rate [18]. It is well known that the overall corrosion reaction of magnesium in aqueous solution at its corrosion potential can be expressed as follows: Figure 9 depicts the cumulative hydrogen gas evolution plots illustrated for the uncoated, MgO-coated, and Si/MgO-coated.…”

“…To overcome this drawback, several surface modification techniques, i.e. electrochemical deposition [15,16], polymer treatment [17,18], chemical deposition [19,20], and micro-arc oxidation (MAO) techniques [21][22][23], have been introduced to improve the degradation rate and bioactivity of magnesium and its alloys [9,24]. As is known, fabrication of magnesium-based composites with bio-ceramic additives [25], besides the surface modification of magnesium implants, and alloying magnesium with biocompatible metals [26,27] are the major techniques to protect the implant from fast corrosion and degradation in vivo.…”

Improving Corrosion Resistance and Biocompatibility of Magnesium Alloy by Sodium Hydroxide and Hydrofluoric Acid Treatments

“…The hydroxyls make the following surface functionalization possible. In our recent study, we demonstrated that the self-assembly can be carried out on the NaOH-treated Mg surface, which can be used to immobilize the biomolecules for improving biocompatibility [26]. For the hydrogen fluoride treated sample, it can be clearly seen that no hydroxyls can be detected and there were two new peaks at 900 and 720 cm −1 , demonstrating that a magnesium fluoride layer was produced after HF treatment.…”

“…On the other side, a high pH value can increase the binding ability of hemoglobin to the membrane and subsequently increase the hemolysis rate, and the red blood cells can fuse with Ca 2+ of the medium, thus resulting in a rupture of erythrocytes, finally leading to serious hemolysis [29]. According to our previous study, the pH value was as high as 8.5 when the pristine magnesium alloy was immersed into SBF for two days [26], and the higher pH value can be obtained when the sample was immersed into SBF for more time. In addition, rapid release of magnesium ions from its fast corrosion is also related to severe hemolysis reaction [30].…”

Corrosion resistance and biocompatibility of magnesium alloy modified by alkali heating treatment followed by the immobilization of poly (ethylene glycol), fibronectin and heparin

“…3-Aminopropyltrimethoxysilane (APTMS) is one of the mostly used self-assembly molecules for the surface modification and it is widely used as the spacer to graft biomolecules on the substrates to enhance the biocompatibility of biomaterials. In our previous study, we demonstrated that the self-assembly of APTMS can be successfully carried out on the alkali heating treated magnesium alloy surface due to its improved corrosion resistance [18], which opened a new feasible way to bio-functionalize the magnesium substrate to enhance the biocompatibility and corrosion resistance. In the present study, poly (ethylene glycol) (PEG) and fibronectin (Fn) or fibronectin/heparin (FH) were successively grafted on the APTMS-modified magnesium alloy surface to impart good biocompatibility and the controllable degradation behaviors.…”