Effects of Serum n-3 to n-6 Polyunsaturated Fatty Acids Ratios on Coronary Atherosclerosis in Statin-Treated Patients With Coronary Artery Disease

Nozue, Tsuyoshi; Yamamoto, Shingo; Tohyama, Shugo; Fukui, Kazuki; Umezawa, Shigeo; Onishi, Yuko; Kunishima, Tomoyuki; Sato, Akira; Nozato, Toshihiro; Miyake, Shogo; Takeyama, Youichi; Morino, Yoshihiro; Takao, Yoshinori; Muramatsu, Toshiya; Hibi, Kiyoshi; Terashima, Mitsuyasu; Michishita, Ichiro

doi:10.1016/j.amjcard.2012.08.038

Cited by 46 publications

(24 citation statements)

References 28 publications

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“…Ratios of n-6/n-3 or n-3/n-6 FA have been used in several studies to assess associations between the FA composition and health outcome or corresponding surrogate markers. 47, 48, 49, 50 Enzyme activity indices estimated from product/precursor ratios for SCD-1 (SCD-16, SCD-18), the rate-limiting enzymes in the biosynthesis of C16:1n-7 and C18:1n-9, and for D6D and D5D, required in the production of eicosanoids from C18:2n-6 and C18:3n-3, are important factors of the blood FA composition besides dietary intake. Studies have shown that obesity and metabolic syndrome are associated with high SCD-1 and D6D indices, and low D5D index.…”

Section: Discussionmentioning

confidence: 99%

Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

et al. 2014

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Objectives:To establish reference values for fatty acids (FA) especially for n-3 and n-6 long-chain polyunsaturated FAs (LC PUFA) in whole-blood samples from apparently healthy 3–8-year-old European children. The whole-blood FA composition was analysed and the age- and sex-specific distribution of FA was determined.Design and subjects:Blood samples for FA analysis were taken from 2661 children of the IDEFICS (identification and prevention of dietary- and lifestyle-induced health effects in children and infants) study cohort. Children with obesity (n=454) and other diseases that are known to alter the FA composition (n=450) were excluded leaving 1653 participants in the reference population.Measurements:The FA composition of whole blood was analysed from blood drops by a rapid, validated gas chromatographic method.Results:Pearson correlation coefficients showed an age-dependent increase of C18:2n-6 and a decrease of C18:1n-9 in a subsample of normal weight boys and girls. Other significant correlations with age were weak and only seen either in boys or in girls, whereas most of the FA did not show any age dependence. For age-dependent n-3 and n-6 PUFA as well as for other FA that are correlated with age (16:0, C18:0 and C18:1n-9) percentiles analysed with the general additive model for location scale and shape are presented. A higher median in boys than in girls was observed for C20:3n-6, C20:4n-6 and C22:4n-6.Conclusions:Given the reported associations between FA status and health-related outcome, the provision of FA reference ranges may be useful for the interpretation of the FA status of children in epidemiological and clinical studies.

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Section: Discussionmentioning

confidence: 99%

Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

et al. 2014

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“…Cumulative average intake incorporates all available data from repeated measures, thereby providing the most stable long-term estimate of adult diet 40. We also examined the ratio of n-3 PUFA and n-6 PUFA intake based on prior work, demonstrating the possible importance of the relative balance of these fatty acids with risk of chronic disease 41 42. Tests for linear trend were conducted using the median value for each quintile as a continuous variable in the regression models based on the assumption of a monotonic dose–response relationship between fat intake and risk of disease.…”

Section: Methodsmentioning

confidence: 99%

Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease

Ananthakrishnan

Khalili

Konijeti

et al. 2013

Gut

430

276

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Introduction Dietary fats influence intestinal inflammation and regulate mucosal immunity. Data on the association between dietary fat and risk of Crohn’s disease (CD) and ulcerative colitis (UC) are limited and conflicting. Methods We conducted a prospective study of women enrolled in the Nurses’ Health Study cohorts. Diet was prospectively ascertained every four years using a validated semi-quantitative food frequency questionnaire. Self-reported CD and UC were confirmed through medical record review. We examined the effect of energy-adjusted cumulative average total fat intake as well as specific types of fat and fatty acids on the risk of CD and UC using Cox proportional hazards models adjusting for potential confounders. Results Among 170,805 women, we confirmed 269 incident cases of CD (incidence 8/100,000 person-years) and 338 incident cases of UC (incidence 10/100,000 person-years) over 26 years and 3,317,338 person-years of follow-up. Cumulative energy-adjusted intake of total fat, saturated fats, unsaturated fats, n-6 and n-3 polyunsaturated fatty acids (PUFA) were not associated with risk of CD or UC. However, greater intake of long-chain n-3 PUFA was associated with a trend towards lower risk of UC (Hazard ratio (HR) 0.72, 95% CI 0.51 – 1.01). In contrast, high long-term intake of trans-unsaturated fatty acids was associated with a trend towards an increased incidence of UC (HR 1.34, 95% CI 0.94 – 1.92). Conclusion A high intake of dietary long-chain n-3 PUFA may be associated with a reduced risk of UC. In contrast, high intake of trans-unsaturated fats may be associated with an increased risk of UC.

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“…Previous studies have demonstrated that the administration of n-3 PUFAs reduced the incidence of adverse cardiovascular events through their beneficial antihyperlipidemic, anti-inflammatory, antioxidative, antiarrhythmic, and anticoagulation effects [5,6,7]. Randomized clinical controlled trials have also shown that n-3 PUFAs not only protected the vascular function in DM, but also reduced the incidence of DM [8,9].…”

Section: Introductionmentioning

confidence: 98%

Regulation of Coronary Arterial Large Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats

Tang¹,

Qian²,

Wang³

et al. 2017

J Vasc Res

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Aim: The objective of this study was to examine the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs)on coronary arterial large conductance Ca²⁺-activated K⁺ (BK) channel function in coronary smooth muscle cells (SMCs) of streptozotocin-induced diabetic rats. Methods: The effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on coronary BK channel open probabilities were determined using the patch clamp technique. The mRNA and protein expressions of BK channel subunits were measured using qRT-PCR and Western blots. The coronary artery tension and coronary SMC Ca²⁺ concentrations were measured using a myograph system and fluorescence Ca²⁺ indicator. Results: Compared to nondiabetic control rats, the BK channel function was impaired with a reduced response to EPA and DHA in freshly isolated SMCs of diabetic rats. Oral administration of n-3 PUFAs had no effects on protein expressions of BK channel subunits in nondiabetic rats, but significantly enhanced those of BK-β₁ in diabetic rats without altering BK-α protein levels. Moreover, coronary ring tension induced by iberiotoxin (a specific BK channel blocker) was increased and cytosolic Ca²⁺ concentrations in coronary SMCs were decreased in diabetic rats, but no changes were found in nondiabetic rats. Conclusions: n-3 PUFAs protect the coronary BK channel function and coronary vasoreactivity in diabetic rats as a result of not only increasing BK-β₁ protein expressions, but also decreasing coronary artery tension and coronary smooth muscle cytosolic Ca²⁺ concentrations.

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Effects of Serum n-3 to n-6 Polyunsaturated Fatty Acids Ratios on Coronary Atherosclerosis in Statin-Treated Patients With Coronary Artery Disease

Cited by 46 publications

References 28 publications

Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

Reference values of whole-blood fatty acids by age and sex from European children aged 3–8 years

Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease

Regulation of Coronary Arterial Large Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats

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