Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats

Abstract

PurposeThe purpose of the present study was to investigate the effect of sesame oil on the reproductive parameters of diabetic male Wistar rats.Materials and MethodsThe adult male rats in a split plot design were divided into normal (n=10), normal 5% (n=5; 5% sesame oil enriched diet), diabetic (Streptozocin induced diabetes; n=9), diabetic 5% (n=9; 5% sesame oil enriched diet), and diabetic 10% (n=9; 10% sesame oil enriched diet) groups. Diet supplementation continued for 56 days.ResultsSesame oil supplementation did not reduce the plasma glucose concentration of rats in the diabetic groups (p>0.05). The total spermatogonia, spermatocytes, Leydig cells/tubule, and the germ cell to Sertoli cell ratio were lower in the diabetic rats than the normal ones (p<0.05), and with the exception of spermatogonia counts, these values improved by the addition of sesame oil to the diet (p<0.05). The sperm progressive motility and viability were lower in the diabetic rats (p<0.05) and sesame oil supplementation did not improve them. Incorporation of sesame oil into the diet improved the plasma testosterone concentration of the diabetic rats in a dose-dependent manner (p<0.05).ConclusionsIn summary, sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function, but was not effective in protecting the epididymal sperm.

Melatonin Ratlarda Alloxan İle İndüklenen Diyabet Sonrası Oluşan Testiküler Hasarı ve Oksidatif Etkileri Hafifletir

“…The capability of MLT to protect body weight losses seems to be a result of its ability to increase antioxidant capacity and reduce the hyperglycemia and ROS. In our study, the total testis weights (except that of the MLT group) did not show any difference between and within the groups studied, as reported by Abbasi et al [37] . In the MLT group, total testis weight decreased markedly from 15 th d to 45 th d.…”

“…No marked change in total sperm number was observed by Abbasi et al [37] , while the daily sperm production in rats and the sperm concentration in mice and rats decreased in the STZ-induced diabetes [4,[40][41][42][43][44] . Herein, the sperm concentration in the 45 th d markedly decreased in the DM group as compared to those in the C group, but the MLT treatment of diabetic rats did not lead to recovering effect for a decrease in the sperm concentration.…”

“…In the experimental studies on the DM, it has been reported that the administration of some antioxidants increases the antioxidant capacity, while decreasing the oxidative stress restoring changes in the spermatological parameters [4,37] . Other antioxidants may not reverse the deterioration in these parameters, but they may restore the daily sperm production in testis, and alleviate the mitochondrial function and DNA damage [42] .…”

“…It was reported in some studies that the rats having undergone the STZ had decreased sperm motility, but without any marked change [4,37,[40][41][42][43][44] . Similarly, herein, we did not find any difference neither between nor within the groups on the 15 th and 45 th d.…”

Effect of Halawa Tahinia Alone or with Ginger and Cinnamon on Sex Hormones in Adult Male Rats

“…Phytoestrogens are phenolic compounds which are similar to hormones and nonsteroidal that derived from estrogen of sesame and are found in sesame seed, affect the reproductive system of male animals [70]. Sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function [71]. Moreover, TAC levels were significantly increased in group that has received 75mg/kg cinnamon daily for 4 weeks in comparison to control group [72].…”