Effects of Sevoflurane and Isoflurane on Hepatic Circulation in the Chronically Instrumented Dog

Bernard, Jean-Marc; Doursout, Marie–Françoise; Wouters, Patrick; Hartley, Craig J.; Merin, Robert G.; Chelly, Jacques E.

doi:10.1097/00000542-199209000-00021

Cited by 87 publications

(42 citation statements)

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“…45 Another study in dogs also found that both isoflurane and sevoflurane caused mild decrease in portal blood flow but no changes in arterial hepatic blood flow. 46 Although potent volatile anesthetics may affect portal blood flow, current evidence suggests that there is well-maintained hepatic and intestinal perfusion in relation to oxygen demand.…”

Section: Microcirculatory and Tissue Perfusion Changes During Anesthementioning

confidence: 99%

Anesthesia and the Microcirculation

Turek

Sýkora

Matějovič

et al. 2009

Semin Cardiothorac Vasc Anesth

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There is increasing evidence that the microcirculation and its regulation are severely compromised during many pathological conditions, such as hemorrhage, sepsis, or trauma. The effects of anesthetic agents on macrohemodynamics were investigated intensively in the last several decades. Research regarding modern anesthetics and anesthesia techniques has increased knowledge regarding the nonanesthetic effects of anesthetic agents, including those on organ perfusion and the microcirculation. Alterations in microvascular reactivity, nitric oxide pathways, and cytokine release are presumably the main mechanisms of anesthetic-induced tissue perfusion changes. This review summarizes current methods of microcirculatory status assessment and current knowledge regarding the microcirculatory effects of intravenous and potent volatile anesthetics and anesthesia-related techniques under both normal and pathophysiological conditions.

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Section: Microcirculatory and Tissue Perfusion Changes During Anesthementioning

confidence: 99%

Anesthesia and the Microcirculation

Turek

Sýkora

Matějovič

et al. 2009

Semin Cardiothorac Vasc Anesth

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“…This encouraged us to test the feasibility of using a smaller and more focused Doppler probe to measure coronary flow velocity and to estimate reserve in a mouse model of atherosclerosis (Plump et al, 1992;Wang, 2005) where we hypothesized that the presence of lesions in the left main coronary artery coupled with volume overload hypertrophy (Hartley et al, 2000) would reduce coronary flow reserve. Thus, we report here a noninvasive method using Doppler ultrasound (Hartley et al, 2000) to measure left main coronary flow velocity and the response to low and high levels of inhaled isoflurane in young and old wildtype, and old (age-matched) ApoE −/− mice (Bernard et al, 1992;Crystal, 1996). We use the response to isoflurane to document systematic differences in baseline and hyperemic coronary flow velocity among the groups and to demonstrate large variations in baseline and hyperemic coronary artery velocities in ApoE −/− mice likely due to the presence of stenotic coronary artery lesions.…”

Section: Introductionmentioning

confidence: 99%

Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE−/− Mice Measured by Doppler Ultrasound

Hartley

Reddy

Madala

et al. 2007

Ultrasound in Medicine & Biology

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The commonly used anesthetic agent, isoflurane (ISO), is a potent coronary vasodilator which could potentially be used in the assessment of coronary reserve, but its effects on coronary blood flow in mice are unknown. Coronary reserve is reduced by age, coronary artery disease, and other cardiac pathologies in man, and some of these conditions can now be modeled in mice. Accordingly, we used Doppler ultrasound to measure coronary flow velocity in mice anesthetized at low (1%) and at high (2.5%) levels of ISO to generate baseline (B) and elevated hyperemic (H) and Y and between A and O were significant (P < 0.01), while the differences in hyperemic velocities were not (P > 0.05). H/B was higher in old mice due to decreased baseline flow rather than increased hyperemic flow velocity. In contrast ApoE −/− mice have increased baseline and hyperemic velocities perhaps due to coronary lesions. The differences in baseline velocities between young and old mice could be due to age-related changes in basal metabolism or to differential sensitivity to isoflurane. We conclude that Doppler ultrasound combined with coronary vasodilation via isoflurane could provide a convenient and noninvasive method to estimate coronary reserve in mice, but also that care must be taken when assessing coronary flow in mice under isoflurane anesthesia because of its potent coronary vasodilator properties.

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“…In our study, the transaminases' values were higher in the case of sevoflurane anesthetized rats, but did not exceed The decreased blood flow during anesthesia, increased calcium concentration in cells (Iaizzo et al, 1990) or anesthetic metabolism products are among the factors that can cause hepatic lesions. Still, some authors think that the hepatic arterial and portal flow are similar during sevoflurane and isoflurane anesthesia (Bernard et al, 1992). Others believe that the prolonged high concentration of intracellular Ca 2+ would be involved in hepatotoxicity mechanism and that isoflurane would stimulate the discharge of intracellular calcium, while the effect of sevoflurane is unknown (Iaizzo et al, 1990).…”

Section: Resultsmentioning

confidence: 99%

Presence and Distribution of the Vascularisation of Aortic Media in Some Mammals

Ruxanda¹,

Damian²,

Rus³

et al. 2015

BUASVMCN-VM

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The specialty literature contains uneven data regarding the effect of inhaled anesthetics on transaminases' values. Various studies show that the transaminases' values range from a small increase up to a massive increase post-anesthesia. In the present study, we utilized 40 rats, divided in 8 groups (n=5). Animals from IsoM and SevoM groups (control) were not anesthetized. Rats from IsoI, Iso2, Iso3 groups were anesthetized with isoflurane, and the ones from Sevo1, Sevo2, Sevo3 groups with sevoflurane (3 times, with 2 days interval between administrations, and the exposure time was 2 hours long every time). After anesthesia, we harvested blood samples at different moments: immediately after the anesthesia (groups IsoM, SevoM, Iso1 and Sevo1), 6 hours post-anestesia (Iso2 and Sevo2) and 24 hours post-anesthesia (Iso3 and Sevo3) and determined the transaminases. Upon statistical analysis, the results indicated the fact that the two anesthetics taken into study did not significantly modify the ASAT values. Also, isoflurane din not significantly modify ALAT values. On the other hand, after sevofluran anesthesia, ALAT values registered a statistically significant change. Enzymatic values ranged between normal limits or were slightly increased over the superior limit, which signifies that at the anesthetic dose and duration from our study, none of the tested anesthetics induce hepatic distress.

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Effects of Sevoflurane and Isoflurane on Hepatic Circulation in the Chronically Instrumented Dog

Cited by 87 publications

References 0 publications

Anesthesia and the Microcirculation

Anesthesia and the Microcirculation

Effects of Isoflurane on Coronary Blood Flow Velocity in Young, Old and ApoE−/− Mice Measured by Doppler Ultrasound

Presence and Distribution of the Vascularisation of Aortic Media in Some Mammals

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