Effects of Shao-Fu-Zhu-Yu-Tang on Motility of Human Sperm

Abstract

Shao-Fu-Zhu-Yu-Tang (SFZYT) is reportedly beneficial to sperm. In this study, we examined sperm acrosomal activity and serum free radical changes to evaluate the possible mechanism of SFZYT. A clinical study evaluated the sperm count and motility in 36 patients with chronic prostatitis before and after treatment for 60 days. The results revealed a significant increase in sperm motility after treatment as evaluated by computer-assisted semen analysis (17.27 +/- 9.00 versus 28.29 +/- 10.00, p < 0.01). An increase in sperm quantity and quality was observed by count and morphology with a high-powered intravital microscope. To gain an understanding of the mechanisms that caused this effect, we assessed sperm acrosin activity levels before (10.6 micro lu/10(6)) and after medication (28.6 micro lu/10(6)) (p < 0.01). The levels of the free radicals was relatively higher before medication, 2144, compared to a normal value of 780 after medication (p < 0.01). In conclusion, SFZYT increased the motility and quality of human semen and this increase is related to an increase in sperm acrosin activity. SFZYT also works as a sperm antioxidant and antiaging agent.

Effect of bajijiasu isolated from Morinda officinalis F. C. how on sexual function in male mice and its antioxidant protection of human sperm

“…These TCMs include Lycium barbarum (Luo et al, 2006), ginseng (De Andrade et al, 2007), Epimedium (Rowland and Tai, 2003), deer antler (Cervus pantotrichum) (Malo et al, 2005), and sea horse (Hippocampus kelloggii) (Low and Tan, 2007). Herbal medicines, such as Gosha-Jinki-Gan (a compound including radix Rehmaniae Preparate, dogwood, astragalus, and 13 other herbs) and Shao-Fu-Zhu-Yu-Tang (a compound including fennel, dried ginger, Rhizoma Corydalis, and seven other component herbs), have been described as improving self-esteem, libido, morning erection, rigidity of the penis, and the duration and quality of ejaculation in men with mild erectile dysfunction, are sperm antioxidants, and improve various semen parameters, such as the sperm count and concentration, viability, mobility, and morphology (Huynh et al, 2000;Rodriguez-Martinez, 2006;Yang et al, 2003). After the administration of Hochu-ekki-to (a compound including astragalus, ginseng, Chinese angelica, and five other herbs), serum soluble FAS levels in the seminal plasma, which correlate with the sperm concentration, were significantly elevated (Furuya et al, 2004).…”

Há evidências científicas na medicina antienvelhecimento?

“…14,28,30,67 A categoria de recomendação desses nove artigos 14,17,25,28,30,64,67,86,109 pode ser considerada "C", e o grau de evidência, "II". 3 Apenas três dos periódicos que publicaram esses artigos 28,30,109 apresentaram fator de impacto acima de 1,110, colocando-os na lista das 1.500 revistas científicas com melhores pontuações por esse critério.…”

“…Excetuando-se o trabalho de Predescu et al 109 com 343 idosos, os outros oito estudos 14,17,25,28,30,64,67,86 relataram casuísticas entre 10 e 83 humanos, ou seja, número de participantes compatível com pesquisas clínicas da fase 1. Apenas dois estudos 28,64 utilizaram fármacos em portadores de doença, mas não apresentaram número de pacientes para serem classificados como fase 2.…”

“…Tendo a presente revisão bibliográfica encontrado apenas nove trabalhos desenvolvidos exclusivamente em seres humanos 14,17,25,28,30,64,67,86,109 e considerando a amplitude proposta como campo de ação da medicina antienvelhecimento, 1 não há sólidas evidên-cias científicas e/ou clínicas que justifiquem sua aplicabilidade na presente prática médica. …”

Komplementärmedizin und assistierte Reproduktion

“…Auch Shao-FuZhu-Yu-Tang (SFZYT), eine Mischung aus vielerlei Pflanzenextrakten, u. a. Fenchel, Myrrhe, Ingwer und Zimt, soll die Motilität und Qualität von menschlichen Spermien erhöhen, indem es die Acrosinaktivität erhöht und als Antioxidans wirkt [32]. Ein anderes Gemisch mit dem Namen Bushen Shengjing-Dekokt (BSSJD) wurde hinsichtlich eines möglichen positiven Effekts auf die Schwangerschaftsrate nach ICSI-Behandlungen geprüft.…”