Effects of Shin'i-seihai-to and Sho-seiryu-to on Production of Active Oxygen Species by Neutrophils.

Matsunaga, Shoichi; Itoh, Kazunori; Babazono, Makiko; Imamura, Yoko; Ohyama, Masaru

doi:10.5631/jibirin.85.1975

Cited by 3 publications

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“…Compared with antihistamines, nasal corticosteroids constitute a potent therapeutic option for UACS in terms of e cacy, side effects, and clari cation of the location of the primary pathophysiology. The e cacy and mechanism of action of herbal medicines used for treating rhinosinusitis have been demonstrated in Japan, China, and Korea [35][36][37][38][39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study

Yasuda

2021

Family Practice

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Background Upper airway cough syndrome (UACS) is generally considered a common cause of chronic cough but remains poorly recognised in Japan. Objective This study aimed to assess whether UACS was a common cause of chronic cough in Japan, as is true in other countries. Interview and examination items were evaluated for their potential use in UACS diagnosis. Methods All patients with chronic cough were preliminarily diagnosed with bronchial asthma, UACS, gastroesophageal reflux disease, or postinfectious prolonged cough, based on interviews and examinations. Treatment centred on nasal steroids was administered to the UACS group and standard treatment to the other groups. The observation period lasted 4 weeks. The subjective cough score at first diagnosis was set at 10, and the final diagnosis was made based on the treatment administered at the time the cough score had decreased to ≤2. The associations between the presence or absence of UACS and interview and examination items were statistically evaluated. Results Among 230 patients with chronic cough, 146 were diagnosed with UACS-only. Multivariate logistic regression revealed that the assessment items ‘awareness of mucus accumulating in the back of the throat’, ‘presence of abnormal echography findings’, ‘absence of associated coughing when exercising’ and ‘presence of coughing persisting after onset’ were significantly correlated with the presence or absence of UACS (p < 0.05). Conclusions UACS may be the most common cause of chronic cough in Japan and may be effectively treated with nasal corticosteroids. Diagnosing UACS might be possible by selecting appropriate interview and examination items.

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Section: Discussionmentioning

confidence: 99%

Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study

Yasuda

2021

Family Practice

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“…Compared with antihistamines, nasal corticosteroids constitute a potent therapeutic option for UACS in terms of efficacy, side effects, and clarification of the location of the primary pathophysiology. The efficacy and mechanism of action of herbal medicines used for treating rhinosinusitis have been demonstrated in Japan, China, and Korea [35][36][37][38][39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study

Yasuda¹

2020

Preprint

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Background: Upper airway cough syndrome (UACS) is generally considered the main cause of chronic cough, but it is rarely recognised in Japan. This study identified the causes of chronic cough and assessed whether “UACS is the most common cause of chronic cough” in Japan, as it is in other countries. Although signs and symptoms of UACS are described as nonspecific, some items of interviews and examinations might be considered potentially useful in its diagnosis, and were evaluated for their association with it. Methods: All patients with chronic cough who visited my clinic were preliminarily diagnosed based on interviews and examinations. Bronchial asthma and UACS were preferentially diagnosed. Among the excluded cases, some patients with gastrointestinal symptoms or diet-related cough were diagnosed with gastroesophageal reflux disease, while others were diagnosed with post-infectious prolonged cough. Nasal corticosteroids were administered to the UACS group, and standard treatment to the other groups. The observation period lasted 4 weeks. Subjective cough score at first diagnosis was set at 10, and final diagnosis was made based on the treatment administered when the cough score had decreased to ≤2. The association between the presence or absence of UACS and interview and examination items was statistically evaluated using a logistic regression model. Results: Among 230 patients with chronic cough, 146 were diagnosed with UACS-only. In the UACS-only group treated with nasal corticosteroids, 110 patients showed a significant improvement in cough scores within 2 weeks. Multivariate logistic regression revealed that assessment items “awareness of mucus accumulating in the back of the throat” (odds ratio [OR]: 4.613; 95% confidence interval [CI]: 1.124–18.928; P=0.034), “presence of abnormal echography findings” (OR: 15.725; 95% CI: 1.445–171.101; P=0.024), “absence of associated coughing when exercising” (OR: 0.212; 95% CI, 0.055–0.813; P=0.024), and “presence of coughing persisting after onset” (OR: 6.470; 95% CI, 1.755–23.843; P=0.005) were significantly associated with the presence or absence of UACS. Conclusions: UACS is the most common cause of chronic cough in Japan, as in other countries, and can be effectively treated with nasal corticosteroids. Diagnosing UACS might be possible by selecting appropriate interview and examination items.

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Effects of Oxygen Radicals on Ciliary Motility in Cultured Human Respiratory Epithelial Cells

et al. 1995

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Effects of Shin'i-seihai-to and Sho-seiryu-to on Production of Active Oxygen Species by Neutrophils.

Cited by 3 publications

References 0 publications

Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study

Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study

Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study

Effects of Oxygen Radicals on Ciliary Motility in Cultured Human Respiratory Epithelial Cells

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