Effects of Short- and Long-Term Celecoxib on Orthodontic Tooth Movement

Abstract

Objective: To test the hypothesis that short-and long-term celecoxib administration has no effect on orthodontic tooth movement. Materials and Methods: Male Wistar rats were submitted to short-(3 days) and long-term (14 days) celecoxib administration, while the respective control groups received equivolumetric saline intraperitoneal injections. The upper left first molars of all rats were moved mesially for 14 days by a fixed orthodontic appliance exerting 50 g force upon insertion. After the experimental period, tooth movement was quantified and tissues around the first molar were processed for tartrateresistant acid phosphatase (TRAP) histochemistry. The amount of tooth movement and the number of TRAP-positive cells on the alveolar bone surface were evaluated. Results: The amount of tooth movement was significantly reduced in rats submitted to short-and long-term celecoxib administration, while the number of osteoclasts on the alveolar bone did not differ between the four groups studied. Conclusions: The hypothesis is rejected. Although celecoxib administration did not affect the number of osteoclasts, the osteoclast activity might be reduced, which could explain the inhibition of tooth movement observed in the celecoxib-treated animals. These results indicate that orthodontists should be aware of patients under short-and long-term therapy with celecoxib.

NSAIDs in orthodontic tooth movement

“…[23] Long-term effect of celecoxib has shown to reduce the rate of orthodontic tooth movement. [26] Acetaminophen is still the drug of choice for treating the discomfort of tooth movement because no advantages are derived from the use of new COX2 inhibiting drugs. [27]…”

The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review

“…The present review shows that paracetamol (acetaminophen) was the only drug that presented unanimous results regarding the influence on orthodontic movement. All studies showed that this drug did not interfere within tooth movement throughout the entire experimental period (Arias and Marquez-Orozco 2006, Hauber Gameiro et al 2008, Gonzales et al 2009). These aspects strengthen the hypothesis that paracetamol does not exert intense activity regarding the inhibition of peripheral synthesis of prostaglandins, reducing the pain by acting along the central nervous system (Arias and Marquez-Orozco 2006).…”

“…Generally, these drugs showed distinct effects regarding orthodontic movement, either having negative influence on it or not interfering with it. However, celecoxib responds more frequently for tooth displacement inhibition, exerting distinct levels of interference in three studies (De Carlos et al 2007, Hauber Gameiro et al 2008, Stabile et al 2009). The distinct effects obtained with the use of these drugs may be related to some factors: the half-life of the drug, the bioavailability, the form of administration, the concentration, the experimental period, and the methods of assessing tooth movement (De Carlos et al 2006, Hauber Gameiro et al 2008.…”

“…Coxibs were used in five studies of the present review (De Carlos et al 2006, Hauber Gameiro et al 2008, Stabile et al 2009, Gonzales et al 2009). Generally, these drugs showed distinct effects regarding orthodontic movement, either having negative influence on it or not interfering with it.…”

“…From the 6 eligible articles, one was performed in Mexico (Arias and Marquez-Orozco 2006), two in Spain (De Carlos et al 2006, two in Brazil (Hauber Gameiro et al 2008, Stabile et al 2009), and one in Japan (Gonzales et al 2009). These publications dated between 2006 and 2009.…”