Effects of short-term ambient PM2.5 exposure on the blood cell count and hemoglobin concentration among 82,431 people in eastern China

Li, Zhongqi; Li, Xiaona; Song, Huan; Tao, Bilin; Qiu, Beibei; Tian, Dan; Zhan, Mengyao; Wu, Zhuchao; Wu, Jizhou; Zhang, Qun; Wang, Jianming

doi:10.1016/j.scitotenv.2021.146046

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…Second, the impact of comorbidities such as coronary artery disease (which may also lead to high monocyte counts) on the observed association between monocyte percentage and AECOPD was unknown and need to be studied 35 . Third, our study lacked the environmental data of patients; however, the effects of short-term exposure to ambient PM2.5 on the blood cell count have been reported 36 . The effects of air pollution on the observed association between monocyte percentage and AECOPD need further investigation.…”

Section: Discussionmentioning

confidence: 96%

Blood monocyte levels predict the risk of acute exacerbations of chronic obstructive pulmonary disease: a retrospective case–control study

Lin

et al. 2022

Sci Rep

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Monocytes were critical cells in the innate immune system. Monocyte recruitment to the lungs is a crucial process of pathophysiology in chronic obstructive pulmonary disease (COPD). Current evidence on the association between the occurrence of acute exacerbations of COPD (AECOPD) and monocytes was unclear. This study aimed to examine whether blood monocytes are associated with the occurrence of AECOPD and to determine the specific blood monocyte level to predict AECOPD. A retrospective case–control study was conducted at Changhua Christian Hospital. A total of 444 eligible patients with COPD were included between January 2017 and December 2019. Restricted cubic splines were used to analyze the nonlinear relationships between continuous white blood cell values and the occurrence of AECOPD. The association between monocytes and the occurrence of AECOPD was assessed using the logistic, lasso, and ridge regression models. Restricted cubic splines revealed nonlinear associations among the monocyte level, the continuous value of the eosinophil-to-lymphocyte ratio, and the occurrence of AECOPD. The lowest risk of occurrence of AECOPD ranged from 7.4 to 10%; < 7.4% with an absolute count < 0.62 or > 10% indicated significant risk. No significant association was noted between the eosinophil-to-lymphocyte ratio categories in the tertiles (< 0.049, 0.049 to < 0.122, and ≥ 0.122) and the risk of AECOPD. A significantly higher risk was noted in the association of the occurrence of AECOPD with the CAT score; mMRC score; wheezing cough; preexisting chronic pulmonary disease; hypertension and malignancy; use of dual- and triple, and oral long-acting bronchodilators for COPD treatment; and WBC count. We reported a nonlinear relationship between monocytes and the occurrence of AECOPD. Patients with monocyte percentage of > 10% or < 7.4% with an absolute count < 0.62 had higher risk of occurrence of AECOPD. Overall, our study demonstrated the specific value of monocytes in identifying high risks of the occurrence of AECOPD; this value is an easy-to-obtain, inexpensive biomarker in patients with AECOPD and should be further investigated in future prospective clinical studies.

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Section: Discussionmentioning

confidence: 96%

Blood monocyte levels predict the risk of acute exacerbations of chronic obstructive pulmonary disease: a retrospective case–control study

Lin

et al. 2022

Sci Rep

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“…In addition, many studies have reported the associations of air pollution with peripheral blood cells and leukemia, which are closely related to hematopoietic function [ 33 – 41 ]. In 1999, Seaton et al reported that PM 10 exposure is associated with not only hemoglobin levels but also packed cell volume, and red blood cell (RBC) count among subjects aged over 60 years [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Association of ambient air pollution with hemoglobin levels and anemia in the general population of Korean adults

Hwang,

Kim

2024

BMC Public Health

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Background Emerging evidence has suggested significant associations between ambient air pollution and changes in hemoglobin levels or anemia in specific vulnerable groups, but few studies have assessed this relationship in the general population. This study aimed to evaluate the association between long-term exposure to air pollution and hemoglobin concentrations or anemia in general adults in South Korea. Methods A total of 69,830 Korean adults from a large-scale nationwide survey were selected for our final analysis. Air pollutants included particulate matter with an aerodynamic diameter less than or equal to 10 micrometers (PM10), particulate matter with an aerodynamic diameter less than or equal to 2.5 micrometers, nitrogen dioxide, sulfur dioxide (SO2), and carbon monoxide (CO). We measured the serum hemoglobin concentration to assess anemia for each participant. Results In the fully adjusted model, exposure levels to PM10, SO2, and CO for one and two years were significantly associated with decreased hemoglobin concentrations (all p < 0.05), with effects ranging from 0.15 to 0.62% per increase in interquartile range (IQR) for each air pollutant. We also showed a significant association of annual exposure to PM10 with anemia (p = 0.0426); the odds ratio (OR) [95% confidence interval (CI)] for anemia per each increase in IQR in PM10 was estimated to be 1.039 (1.001–1.079). This association was also found in the 2-year duration of exposure (OR = 1.046; 95% CI = 1.009–1.083; adjusted Model 2). In addition, CO exposure during two years was closely related to anemia (OR = 1.046; 95% CI = 1.004–1.091; adjusted Model 2). Conclusions This study provides the first evidence that long-term exposure to air pollution, especially PM10, is significantly associated with reduced hemoglobin levels and anemia in the general adult population.

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“…Minimizing the AIC value was applied to identify the optimal lag time 14 – 16 . We expressed the effects as the estimated changes in blood lipid-related indicators and their 95% confidence intervals (CIs) for a 10 μg/m 3 increase in ambient PM 2.5 concentration 15 . We also converted lipid-related indicators into dichotomous variables (normal and abnormal) to calculate risks of hyperlipidemia associated with PM 2.5 exposure, and expressed them as the odds ratio (OR) as well as their 95% CIs for 10 μg/m 3 rise in outdoor PM 2.5 concentration.…”

Section: Methodsmentioning

confidence: 99%

“…The heterogeneity effects between subgroups were evaluated using the formula: , where and are the estimated effects, and and are their standard errors, respectively. When the value was larger than 1.96, the difference was considered statistically significant 15 .…”

Section: Methodsmentioning

confidence: 99%

Effects of short-term PM2.5 exposure on blood lipids among 197,957 people in eastern China

Wang

et al. 2023

Sci Rep

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Globally, air pollution is amongst the most significant causes of premature death. Nevertheless, studies on the relationship between fine particulate matter (PM2.5) exposure and blood lipids have typically not been population-based. In a large, community-based sample of residents in Yixing city, we assessed the relationship between short-term outdoor PM2.5 exposure and blood lipid concentrations. Participants who attended the physical examination were enrolled from Yixing People’s hospital from 2015 to 2020. We collected general characteristics of participants, including gender and age, as well as test results of indicators of blood lipids. Data on daily meteorological factors were collected from the National Meteorological Data Sharing Center (http://data.cma.cn/) and air pollutant concentrations were collected from the China Air Quality Online Monitoring and Analysis Platform (https://www.aqistudy.cn/) during this period. We applied generalized additive models to estimate short-term effects of ambient PM2.5 exposure on each measured blood lipid-related indicators and converted these indicators into dichotomous variables (non- hyperlipidemia and hyperlipidemia) to calculate risks of hyperlipidemia associated with PM2.5 exposure. A total of 197,957 participants were included in the analysis with mean age 47.90 years (± SD, 14.28). The increase in PM2.5 was significantly associated with hyperlipidemia (odds ratio (OR) 1.003, 95% CI 1.001–1.004), and it was still significant in subgroups of males and age < 60 years. For every 10 μg/m3 increase in PM2.5, triglyceride levels decreased by 0.5447% (95% CI − 0.7873, − 0.3015), the low-density lipoprotein cholesterol concentration increased by 0.0127 mmol/L (95% CI 0.0099, 0.0156), the total cholesterol concentration increased by 0.0095 mmol/L (95% CI 0.0053, 0.0136), and no significant association was observed between PM2.5 and the high-density lipoprotein cholesterol concentration. After excluding people with abnormal blood lipid concentrations, the associations remained significant except for the high-density lipoprotein cholesterol concentration. PM2.5 was positively correlated with low-density lipoprotein cholesterol and total cholesterol, and negatively correlated with triglyceride, indicating PM2.5 can potentially affect health through blood lipid levels.

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Effects of short-term ambient PM2.5 exposure on the blood cell count and hemoglobin concentration among 82,431 people in eastern China

Cited by 11 publications

References 32 publications

Blood monocyte levels predict the risk of acute exacerbations of chronic obstructive pulmonary disease: a retrospective case–control study

Blood monocyte levels predict the risk of acute exacerbations of chronic obstructive pulmonary disease: a retrospective case–control study

Association of ambient air pollution with hemoglobin levels and anemia in the general population of Korean adults

Effects of short-term PM2.5 exposure on blood lipids among 197,957 people in eastern China

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