Effects of short‐term lifestyle activity modification on adiponectin mRNA expression and plasma concentrations

Abstract

Adiponectin mRNA and plasma concentrations were reduced in obesity. Exercise training may reduce the adipose tissue (AT), although it is not well known, whether exercise - induced change in AT, increases adiponectin mRNA expression and plasma concentrations or not. Therefore, the purpose of this study was to examine the effects of short-term lifestyle activity modification (LAM) on adiponectin mRNA and plasma concentrations. Sixteen obese and overweight middle-aged men (age, 35-50 years) with type 2 diabetes participated in this study. The subjects were randomly assigned to LAM group (n=8) or control group (n=8). The subjects in LAM group walked two miles in 30 min on a treadmill on 4 days per week for 12 weeks according to the guidelines of the Centers for Disease Control and Prevention and American College of Sports Medicine. The results showed that body mass, body mass index, central visceral adipose tissue and subcutaneous adipose tissue volume and hip and thigh subcutaneous adipose tissue (hip and thigh SAT) volume were decreased in the LAM group compared to the control group (P<0.05). Adiponectin mRNA in abdominal and gluteal subcutaneous AT were increased significantly in the LAM group compared to the control group (P<0.05), while plasma adiponectin concentrations, hs-CRP and insulin resistance did not change significantly. In conclusion, adiponectin mRNA levels increase after 12 weeks of LAM; however, plasma adiponectin levels were not affected by this protocol in obese and overweight middle-aged men with type 2 diabetes.

Physical Exercise on Inflammatory Markers in Type 2 Diabetes Patients: A Systematic Review of Randomized Controlled Trials

“…Eight studies presented their data as mean values ± standard deviations [22–27, 29, 30], one as mean ± standard error of the mean [21], another as median ± standard deviation [20], and one as mean and confidence interval [28]. …”

“…Moghadasi et al's (2013) [30] study had a sample composed of just men. The average age of the participants showed a little variation between the RCTs, with averages ranging from 48 to 68 years of age.…”

“…The studies that compare a group of individuals who performed aerobic exercise with a control group [21–23, 26, 28–30] present contradictory results about the effectiveness of training to reduce plasma CRP levels. While Kadaglou et al [26], Oberbach et al [21], and Kadaglou et al [29] reported a reduction in the plasma CRP levels of trained individuals, three other studies found no significant difference in this parameter [22, 28, 30] when comparing the control group versus the aerobic group after the intervention.…”

“…While Kadaglou et al [26], Oberbach et al [21], and Kadaglou et al [29] reported a reduction in the plasma CRP levels of trained individuals, three other studies found no significant difference in this parameter [22, 28, 30] when comparing the control group versus the aerobic group after the intervention. It was not possible to identify a specific outcome of exercise that could be related to different results from these studies.…”

Exercise and Regulation of Adipokine and Myokine Production

“…[89][90][91][92] On the other hand, Saunders et al reported increased adiponectin plasma levels following an acute bout of exercise in sedentary obese men. 93 With regard to chronic exercise intervention, most studies using endurance type training with moderate intensity reported no change in plasma levels of adiponectin, 88,94-97 while mRNA expression in adipose tissue was found either increased 94,96 or unmodified. 97 In contrast, two studies that used chronic endurance exercise protocols reported increased plasma adiponectin levels in obese young women 98 and in overweight patients with impaired glucose metabolism 78 after the intervention period.…”