Effects of Shuganjianpihuatanxingqi decoction on mild subclinical hypothyroidism

Abstract

Introduction:Mild subclinical hypothyroidism (SCH) can cause depression, fatigue, cognitive dysfunction, or other hypothyroid symptoms, and even progress to hypothyroidism. The treatment of mild SCH is controversial. Shuganjianpihuatanxingqi decoction (SD) is a frequently prescribed Chinese herbal medicine in patients with mild SCH. However, scientific evidence is needed to confirm the therapeutic effect of SD.Methods and analysis:This study is a randomized, double-blind, and controlled clinical trial. A total of 228 participants with the diagnosis of mild SCH will be randomly assigned to the SD or placebo group in a ratio of 1:1. Participants will receive treatment for 12 weeks and undergo 12-month follow-up. The primary outcome measure is the thyroid-stimulating hormone level, and secondary outcomes will be the differences in the results of Thyroid-related Quality of Life Questionnaire, blood lipids, and Traditional Chinese Medicine Symptom Score Scale between baseline and at 12 weeks after intervention.Ethics and dissemination:The study has been approved by Guang’anmen Hospital of China Academy of Chinese Medical Sciences (no.2018-005-ky-01). The trial results will be published via peer-reviewed journals and the Clinical Research Information Service.Trial registration number:ChiCTR1800015781 (approval date: 20 April 2018).

A Network Pharmacology Approach to Determine the Mechanisms of Action of Shuangshen Granules in Suppressing Pancreatic Cancer Precursor Lesions

“…As an important part of conventional medicine, traditional Chinese medicine (TCM) has been used clinically for more than several thousand years. It has several bene ts such as its satisfactory curative effects, and its low prevalence of side effects and cost, and has been gradually accepted by the public both in China and internationally [9][10][11][12][13]. Studies have shown that Chinese herbal compounds can regulate cell apoptosis via multiple pathways [14], can reduce the angiogenesis response of rats with precursor lesions, alleviate microvascular abnormalities [15] and regulate blood ow disorders which can delay, block, or reverse the development of precursor lesions [16].…”