Effects of Sidr honey on second-intention healing of contaminated full-thickness skin wounds in healthy dogs

Hananeh, Wael M.; Ismail, Zuhair Bani; Alshehabat, Musa A.; Abeeleh, Mahmoud Abu; Ali, Ja’far Hasan

doi:10.1515/bvip-2015-0063

Cited by 13 publications

(4 citation statements)

References 18 publications

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“…The medicinal significance of honey has been reported in the historical scientific literatures. The healing property of honey is mainly due to its antibacterial activity, maintaining a moist wound condition and its high viscosity that helps to provide a protective barrier to prevent the infection ( Manisha and Shyamapada, 2011 , Hananeh et al, 2015 ). Honey has been identified for its outcome on the healing process ( Nasir et al, 2010 ) with multiple positive effects on wound ( Jull et al, 2013 ) and is considered to enhance circulation and healing growth.…”

Section: Honey In Wound Healingmentioning

confidence: 99%

Role of honey in modern medicine

Meo

AlAsiri

Mahesar

et al. 2017

Saudi Journal of Biological Sciences

230

147

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Use of honey has a very long history. Honey has been used since ancient time due to its nutritional and therapeutic values. There had been varied ways of consumption honey including its use as a sweetener and flavoring agent. Honey is produced all over the world. The most important nutriment of honey is carbohydrates present in the form of monosaccharides, fructose and glucose. Honey plays an important role as an antioxidant, anti-inflammatory, anti-bacterial agent and augments the adherence of skin grafts and wound healing process. The role of honey has been acknowledged in the scientific literature and there is convincing evidence in support of its antioxidant and antibacterial nature, cough prevention, fertility and wound healing properties. However, its use has been controversially discussed and has not been well accepted in the modern medicine. The aim of this review was explore and highlight the role of honey in modern medicine.

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Section: Honey In Wound Healingmentioning

confidence: 99%

Role of honey in modern medicine

Meo

AlAsiri

Mahesar

et al. 2017

Saudi Journal of Biological Sciences

230

147

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“…Honey has been shown to possess many medicinal properties, including anti-inflammatory effects, analgesic effects, deodorizing effects, and hygroscopic effects. Clinically, honey has been shown to decrease wound exudation, enhance immune response at the wound site, stimulate healthy granulation tissue formation, minimize scar tissue formation, and reduce the incidence of wound infections [ 15 - 20 ].…”

Section: Introductionmentioning

confidence: 99%

Wound healing in immunocompromised dogs: A comparison between the healing effects of moist exposed burn ointment and honey

et al. 2020

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Background and Aim: Natural topical products have been used to enhance wound healing, especially in immunocompromised animals. The aims of this study were to evaluate and to compare the effects of moist exposed burn ointment (MEBO) and honey on the healing of full-thickness skin wounds in immunocompromised dogs. Materials and Methods: The study was conducted using 12 adults, apparently healthy mongrel dogs. Immunosuppression was induced in six dogs by oral administration of prednisone (2 mg/kg) and azathioprine (2 mg/kg), once a day for 21 days. On each dog, a total of 9, 1.5 cm in diameter full-thickness skin circular wounds were created aseptically in the thoracolumbar area under general anesthesia using customized skin punch biopsy kit. In a random fashion, three wounds in each dog were treatment using MEBO (contains b-sitosterol, baicalin, and berberine as active ingredients in a base of beeswax and sesame oil), honey or no treatment (control), once per day for 21 days. Wounds were grossly evaluated once a day for signs of inflammation or infection. In addition, biopsy specimens and digital imaging data of each wound were obtained on days 7, 14, and 21 for histopathological evaluation of the healing process. Results: Wounds in immunocompromised dogs appeared to heal significantly in a slower fashion than in non-immunocompromised counterparts. Digital analysis data showed that MEBO-treated wounds expressed better epithelialization area, faster contraction, and smaller wound area percentage when compared with honey-treated wounds. Histopathological analysis showed significantly higher angiogenesis scores in MEBO-treated wounds when compared with other treatments. Conclusion: Results of this study showed that MEBO resulted in significant enhancement of wound healing in both healthy and immunocompromised dogs. However, when compared to honey, the wound healing effect of MEBO was superior to that of honey.

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“…Wounds treated by Sidr honey healed faster as compared with iodine dressing. Topical application of Sidr honey is an excellent dressing for wound infected with MRSA without any side effects 28 .Topical application of Sidr honey is an excellent alternative for wound infected with MRSA without any concern of systemic side effects 29 . Raw unprocessed honey is a good, simple and effective solution for eradication of biofilms and enhances healing in non-healing ulcers 30 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Bee Honey on Wound Healing: Split Skin Graft with Hyper-granulation Tissue

Wadi

Geregandi²

2020

Journal of Natural Remedies

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The present prospective study was aimed to evaluate the effectiveness of topical application of bee honey on wound healing with hyper granulation tissue of infected split skin graft. Methods: A 27 years old female was admitted to Khartoum North Teaching Hospital plastic surgery unit with painful swelling of the right buttock with localized heat, which was proved as a pyogenic abscess. Swabs were taken from the wound for isolation, identification and viable bacterial count. The abscess was drained under general anesthesia and dressed with saline and MEBO ointment (combination of honey and herbs). Skin graft was performed. After 2 weeks of MEBO dressing, the wound was infected and hyper granulation tissue was observed. Daily application of honey was used instead of MEBO ointment. Results: Isolated organism was identified as Staphylococcus aureus. In vitro antibacterial test of honey against the isolated organism exhibited strong antibacterial activity. After one week of honey dressing, bacterial growth was inhibited and finally the wound was free from S. aureus. After 2 weeks of honey dressing, wound healing with reduced, hyper-granulation tissue was found. Conclusion: Topical application of honey dressing on wound with hyper granulation tissue for 3 weeks resulted in clean sterile wound with healthy granulation tissue and prompt graft was observed. Complete wound healing was achieved and hyper granulation tissue was reduced without surgical interference.

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Effects of Sidr honey on second-intention healing of contaminated full-thickness skin wounds in healthy dogs

Cited by 13 publications

References 18 publications

Role of honey in modern medicine

Role of honey in modern medicine

Wound healing in immunocompromised dogs: A comparison between the healing effects of moist exposed burn ointment and honey

Efficacy of Bee Honey on Wound Healing: Split Skin Graft with Hyper-granulation Tissue

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