Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats

Du, Zhibin; Chen, Jiang; Yan, Fuhua; Xiao, Yin

doi:10.1111/j.1600-0501.2008.01630.x

Cited by 117 publications

(137 citation statements)

References 23 publications

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“…In addition, systemic high dose treatment improved peri-implant bone deposition in the implant carrying tibial medullar cavity of intact skeletally mature 30-week-old female rats . Moreover, systemic application of simvastatin to 5-month-old rats, which had been ovariectomised two months prior to implant placement, also enhanced osseointegration (Du et al, 2009). We used in our study older animals than any previous study and placed implants after a more extended oestrogen deprival induced bone loss period, while the examined implant healing intervals were comparable to other studies.…”

Section: B Stadlinger Et Al Modified Implants In An Osteoporosis Modelmentioning

confidence: 72%

“…This has been explored utilising statin coated implants , based on the finding that statins induce bone morphogenetic protein-2 (BMP-2) expression and promote osteoblastic BMP signalling (Mundy et al, 1999), which is critical during osseointegration and fracture healing. Also for this approach positive findings were reported in a pre-clinical animal model (Du et al, 2009).…”

Section: Modified Implants In An Osteoporosis Modelmentioning

confidence: 94%

“…In addition, a putative inhibition of osteoclast activation has been proposed . Statins have been applied in various animal models of osseointegration and improved implant integration rates in non-compromised Moriyama et al, 2010) and osteoporotic animal models (Du et al, 2009) have been reported. Local application of fluvastatin increased peri-implant bone formation in the tibial bone of oestrogen competent growing ten-week-old female rats, .…”

Section: B Stadlinger Et Al Modified Implants In An Osteoporosis Modelmentioning

confidence: 99%

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Osseointegration of biochemically modified implants in an osteoporosis rodent model

Stadlinger

Korn

Tödtmann

et al. 2013

eCM

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The present study examined the impact of implant surface modifications on osseointegration in an osteoporotic rodent model. Sandblasted, acid-etched titanium implants were either used directly (control) or were further modified by surface conditioning with NaOH or by coating with one of the following active agents: collagen/chondroitin sulphate, simvastatin, or zoledronic acid. Control and modified implants were inserted into the proximal tibia of aged ovariectomised (OVX) osteoporotic rats (n = 32/group). In addition, aged oestrogen competent animals received either control or NaOH conditioned implants. Animals were sacrificed 2 and 4 weeks post-implantation. The excised tibiae were utilised for biomechanical and morphometric readouts (n = 8/group/readout). Biomechanical testing revealed at both time points dramatically reduced osseointegration in the tibia of oestrogen deprived osteoporotic animals compared to intact controls irrespective of NaOH exposure. Consistently, histomorphometric and microCT analyses demonstrated diminished bone-implant contact (BIC), periimplant bone area (BA), bone volume/tissue volume (BV/ TV) and bone-mineral density (BMD) in OVX animals. Surface coating with collagen/chondroitin sulphate had no detectable impact on osseointegration. Interestingly, statin coating resulted in a transient increase in BIC 2 weeks post-implantation; which, however, did not correspond to improvement of biomechanical readouts. Local exposure to zoledronic acid increased BIC, BA, BV/TV and BMD at 4 weeks. Yet this translated only into a non-significant improvement of biomechanical properties. In conclusion, this study presents a rodent model mimicking severely osteoporotic bone. Contrary to the other bioactive agents, locally released zoledronic acid had a positive impact on osseointegration albeit to a lesser extent than reported in less challenging models.

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Section: B Stadlinger Et Al Modified Implants In An Osteoporosis Modelmentioning

confidence: 72%

Section: Modified Implants In An Osteoporosis Modelmentioning

confidence: 94%

Section: B Stadlinger Et Al Modified Implants In An Osteoporosis Modelmentioning

confidence: 99%

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Osseointegration of biochemically modified implants in an osteoporosis rodent model

Stadlinger

Korn

Tödtmann

et al. 2013

eCM

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“…Background: the primary objective for many researches carried out in dental implantology was to reduce the period needed for functional implant loading, simvastatin (cholesterol lowering medication) had many pleiotropic effects, one of which was increasing bone density around titanium implants (1) and subsequently establishing faster osseointegrated dental implants (2,3) . Aim of the study: this study aims to reduce the period of time needed to establish secondary stability of dental implant measured in ISQ (Implant Stability Quotient) by investigating the effect of orally administered simvastatin on bone.…”

Section: Introductionmentioning

confidence: 99%

Effect of Systemic Administration of Simvastatin on Dental Implant Stability: A Random Clinical Study

Mohammed¹,

Kayat²

2016

Iraqi dent. j.

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Background: the primary objective for many researches carried out in dental implantology was to reduce the period needed for functional implant loading, simvastatin (cholesterol lowering medication) had many pleiotropic effects, one of which was increasing bone density around titanium implants (1) and subsequently establishing faster osseointegrated dental implants (2,3) . Aim of the study: this study aims to reduce the period of time needed to establish secondary stability of dental implant measured in ISQ (Implant Stability Quotient) by investigating the effect of orally administered simvastatin on bone. Materials and methods: simvastatin tablets (40mg/day for three months) were administered orally for 11 healthy women aged (40-51) years old who received 15 dental implants (Dentium, Implantium) in the traumatic functional implant zone (4) , this is the intervention group, the control group (n=11) received 14 dental implants in the same zone. 3 dental implants in 2 subjects were lost, leaving a total of 26 dental implants in 20 patients with 10 patients in each group. All subjects were radiographed with OPG for preliminary assessment and with CT scan for registering bone density in Hounsfield Units. Different dental implant sizes were used according to optimal patients' needs. an informed consent was obtained from the intervention group and the recommended monitoring protocol was followed. Dental implant stability ISQ were recorded using RFA by Osstell TM ISQ for both groups three times: immediately after implant placement (at surgery) and after 8,12 weeks respectively. Results: results showed that the mean implant stability for the intervention group was significantly higher P= 0.01 after 12 weeks in comparison to that of the control group. Simvastatin showed statistically significant effect on implant stability among the intervention group after 8 and 12 weeks (P value for both times <0.001) with the attributed risk percent was 70.8 and 50 respectively. Conclusions: this study concluded that the intervention group had higher implant stability and was ready for functional loading prior to control group and that simvastatin might enhanced and/or accelerated the process of osseointegration.

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“…Though some animal tests show that systemic administration could facilitate osteogenesis process [5]. However, systemic administration required much higher doses, which is considerable harm to healthy, because of the most of the simvastatin are metabolized in the liver, that would cause a shortage concentration for topical bone to stimulate bone formation [6].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Simvastatin Loaded TiO2 nanotube arrays and its release behavior

Tang

Xiao²,

Chen

et al. 2012

Proceedings of the 2nd International Conference on Electronic and Mechanical Engineering and Information Technology (2012)

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Abstract. TiO 2 nanotube array fabricated by anodization has large specific surface area and good biocompatibility. The simvastatin (SIM), which can promote bone formation, were filled into the TiO 2 nanotube by using step concentration soaking method(SCS).The morphology of TiO 2 nanotube arrays were observed by scanning electronic microscope, and the drug release in phosphate buffer solution (PBS) were determined by visible ultraviolet spectrophotometer. The results show that the simvatatin has been loaded into the TiO 2 nanotube arrays, and could sustain release 15 days.

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Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats

Abstract: Osteoporosis can significantly influence bone healing in the cancellous bone around titanium implants and Simvastatin was shown to significantly improve the osseointegration of pure titanium implants in osteoporotic rats.

Cited by 117 publications

References 23 publications

Osseointegration of biochemically modified implants in an osteoporosis rodent model

Osseointegration of biochemically modified implants in an osteoporosis rodent model

Effect of Systemic Administration of Simvastatin on Dental Implant Stability: A Random Clinical Study

Preparation of Simvastatin Loaded TiO2 nanotube arrays and its release behavior

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