Effects of Single-Dose Pregabalin on Postoperative Pain in Dacryocystorhinostomy Surgery

Abstract

Postoperative pain of dacryocystorhinostomy surgery is one of the serious issues to be considered. Utilizing other drugs instead of opioids can be an appropriate and practical solution in controlling the patients' pain. In this study we discuss effectivness of pregabalin in post-operative pain management in dacryocystorhinostomy surgery.Background: Postoperative pain of dacryocystorhinostomy (DCA) surgery is one of the serious issues to be considered. Administrating opioids to relieve postoperative pain and facing their increasing side effects in eye surgeries, make the use of non-opioid drugs inevitable. Objectives: The present study examined the efficacy of pregabalin in alleviating the postoperative pain of DCA surgery. Patients and Methods:The present study has been carried out as a double-blind, randomized clinical trial on the patient candidates for DCR. The patients were randomly divided in to two groups of pregabalin and placebo. Patients in pregabalin group received 300 mg of pregabalin, an hour before the operation in the morning of the surgery. Pain intensity on visual analog scale (VAS) was recorded until 24 hours after the operation; also the rate of administrated opioids and nausea/vomiting frequency were recorded during the first 24-hour period after the operation and the resultsof the two groups were compared. Results: Postoperative pain intensity in the pregabalin group at the time of recovery was significantly lower than that of the placebo group (P = 0.001) until 24 hours after the surgery. In the pregabalin group 17.5% of the patients received opioids while in the placebo group the figure was 52.5% (P = 0.001). Nausea frequency was also higher in the placebo group than the pregabalin group (P = 0.003). Conclusions: A single 300 mg dose of pregabalin, an hour before DCA can effectively reduce pain intensity and also reduce opioid dose and nausea/vomiting.

A Comparative Evaluation of Pre-Emptive Doses of Gabapentin and Pregabalin for Postoperative Relief of Pain in Patients Scheduled for Surgery Under General Anaesthesia

“…Alimian M. et al 16 and Alimian M. et al 17 in their respective studies also observed that postoperative pain intensity level were lower in patients who received oral 300 mg Pregabalin an hour before surgery. Opioid consumption were also lower in the Pregabalin group than the placebo group.…”

Comparative study of single dose pre-emptive pregabalin vs. Placebo for post-operative pain relief in middle ear surgery

“…Alimian et al 14 in their study concluded that apart from sedation, nausea and vomiting were also seen in pregabalin group but much less than in the control group. So, it was not statistically significant.…”

Is pregabalin effective and safe in total knee arthroplasty? A PRISMA-compliant meta-analysis of randomized-controlled trials

“…[ 5 , 6 ] Considering the various adverse effects of opioid analgesics, the use of some nonopioid agent, such as pregabalin, is often recommended. [ 7 ] As a 3rd-generation anticonvulsant agents, pregabalin can selectively affects the nociceptive process by inhibiting calcium influx via voltage-gated calcium channels. [ 8 ] It not only played the key role in both central and peripheral analgesia, but also relatively well-tolerated.…”