Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population

Abstract

Background Growing evidence indicates that poor sleep harms health. Early to bed and early to rise is considered as a healthy lifestyle in Chinese population. The current study aimed to examine the effects of sleep habits on acute myocardial infarction (AMI) risk and severity of coronary artery disease (CAD) in Chinese population from two centers. Methods A total of 873 patients including 314 AMI and 559 controls were recruited from the inpatient cardiology department of the Affiliated Jiangning Hospital and the First Affiliated Hospital of Nanjing Medical University. 559 controls included 395 CAD cases and 164 non-CAD cases. We used a 17-item sleep factors questionnaire (SFQ) to evaluate sleep habits comprehensively by face-to-face interview. The severity of CAD was assessed by Gensini score in AMI and CAD groups. The effects of sleep factors on AMI risk and Gensini score were examined by unconditional logistic regression. Results After mutually adjustment for other sleep factors and demographic characteristics, the timing of sleep (24:00 and after), sleep duration (< 6h) and frequency of night-time waking (3 times) were associated with increased risk of AMI. In subjects with age < 65 years, sleep duration (< 6h) was correlated with increased risk of AMI (OR 3.096, 95%CI 1.435–6.681, P = 0.004) and daytime napping was related to reduced risk of AMI (OR 0.620, 95%CI 0.397–0.970,P = 0.036). In the population aged ≥ 65 years, the level 3 of light exposure (they could see only the hazy outline of the bedroom) was correlated with lowered risk of AMI. Late sleep timing (24:00 and after) and the frequency of night-time waking (3 times) were associated with increased risk of AMI independently of age. Moreover, Short sleep duration was correlated with increased risk of high Gensini score. Conclusion Late sleeping is an important risk factor for AMI. Daytime napping may protect the population aged < 65 years.

One night of sleep deprivation induces release of small extracellular vesicles into circulation and promotes platelet activation by small EVs

“…38 Insufficient or disrupted sleep increases the risk of multiple pathological conditions, including acute myocardial infarction and coronary artery disease. 39,40 EVs emerge as comprehensive signalling entities mediating adaptive responses over large distances with widespread implications in physiology. 2,41 In this reported the plasma exosome might contribute to adipocyte metabolic dysfunction in patients with sleep-disordered-breathing (SDB), which is characterized by chronic intermittent hypoxia and sleep fragmentation.…”

“…Sleep is integral to life 38 . Insufficient or disrupted sleep increases the risk of multiple pathological conditions, including acute myocardial infarction and coronary artery disease 39,40 . EVs emerge as comprehensive signalling entities mediating adaptive responses over large distances with widespread implications in physiology 2,41 .…”

Sleep Quality Among Patients with Myocardial Infarction

“…[2][3] Sleep durations that are longer or shorter than 7-8 hours in a 24-hour period are associated with cardiovascular diseases (CVDs), diabetes risk factors and increased risk of myocardial infarction (MI). [4][5][6][7][8][9][10][11] Besides this, poor sleep quality, short sleep duration and overnight shift work are also associated with all-cause mortality and major adverse cardiovascular events in patients with MI. [12][13][14] Good sleep is vital for a healthy heart.…”