Effects of sodium hyaluronate and methylprednisolone acetate on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1

Abstract

Our results indicate that MPA in combination with HA has beneficial effects on PG metabolism of IL-1-treated equine chondrocytes.

The use of intra‐articular corticosteroids in the horse: What is known on a scientific basis?

“…2006). In the second study, MPA in combination with HA, was considered to have beneficial effects on proteoglycan metabolism in IL‐l treated equine chondrocytes (but there were no comparisons between HA alone and MPA plus HA) (Yates et al. 2006).…”

Current joint therapy usage in equine practice: A survey of veterinarians 2009

“…While in vivo and in vitro studies have shown reduction in signs of joint inflammation with MPA treatment (Frisbie et al. 1998; Yates et al. 2006), research has also shown detrimental effects for articular cartilage (Frisbie et al.…”

Osteoarthritis in horses - Part 2: a review of the intra-articular use of corticosteroids as a method of treatment

“…However, controlled trials have not shown an adequate reduction of pain symptoms or the action on the cartilage matrix when used alone or in combination with SH (Doyle et al 2005;Yates et al 2006). Further, to date, in vitro studies have not provided sufficient data to demonstrate that COs are not potentially negative for articular cartilage.…”