Effects of sodium polyacrylate (PANa) on acute esophagitis by gastric juice in rats.

Abstract

Abstract-Sodium polyacrylate (PANa) is a water-soluble, high-molecular compound, and its aqueous solution shows a very high viscosity and stringiness.In the present study, preventive effects of PANa on three kinds of esophageal lesions induced by gastric juice were examined in comparison with those of aceglutamide aluminium and sodium alginate.

Experimental model of gastroesophageal reflux in rats

“…Ferguson 19 developed a model in rats and other animal species, by occluding the duodenum below the pylorus, and associating with the administration of histamine. Nakamura et al 5 , Inatomi 6 and Omura 4 developed experimental models of acid and chronic reflux esophagitis by occluding the rumen and obstructing the pylorus. The model developed by Nakamura et al 5 had the disadvantage of causing extrinsic (mechanical) gastric obstruction.…”

“…Nakamura et al 5 , Inatomi 6 and Omura 4 developed experimental models of acid and chronic reflux esophagitis by occluding the rumen and obstructing the pylorus. The model developed by Nakamura et al 5 had the disadvantage of causing extrinsic (mechanical) gastric obstruction. Several factors will interfere with the analysis of esophagitis as a cause of reflux due to vascular compression associated with bacteria proliferation, resulting from gastric obstruction.…”

“…The obstruction of the stomach occurring in the models mentioned above impairs the performance of the surgical technique (if used). The second disadvantage in Nakamura et al 5 model was the short survival of animals, thus being hardly applicable, since it caused acute esophagitis in too short a time to allow evaluation of therapeutic effect of the drugs tested. In the study published by Melo 22 , the rats underwent cardioplasty and esophagoduodenostomy.…”

“…Experimental models of GERD are important to study the action of the acid and alkaline juices, as well as to evaluate the therapeutic efficacy of drugs and surgical techniques. The closure of the pylorus and of the rumen helped studying reflux esophagitis in rats, according to the models developed 4,5,6 . The authors also tested the therapeutic efficacy of different esophageal mucosa protective drugs.…”

Mucosal Protective Effect of Leminoprazole on Reflux Esophagitis Induced in Rats

“…Under ether anesthesia, the abdomen was incised along the midline and then both the pylorus and limiting ridge (transitional region between the forestomach and corpus) were simultaneously ligated according to the method described by Nakamura et al (10). Consequently, the total capacity of the stomach to preserve the gastric juice was greatly diminished, resulting in the reflux of gastric juice into the esophagus.…”