Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

Patntirapong, Somying; Habibović, Pamela; Hauschka, Peter V.

doi:10.1016/j.biomaterials.2008.09.062

Cited by 103 publications

(101 citation statements)

References 49 publications

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“…In addition, there were four cases (7%) of metallosis directly associated with degradation of the second junction that contributed to revision of the device. Several studies show degradation products from metallic devices may have deleterious local and systemic biologic and clinical effects over the short and long term [13,14,20] (Table 6). Metal release likely emanates from modular head-neck junctions, rather than passive surface dissolution [14].…”

Section: Resultsmentioning

confidence: 99%

Proximal Component Modularity in THA—At What Cost?: An Implant Retrieval Study

Kop

Keogh

Swarts

2012

Clinical Orthopaedics &Amp; Related Research

130

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Background While modular femoral heads have been used in THA for decades, a recent innovation is a second neck-stem taper junction. Clinical advantages include intraoperative adjustment of leg length, femoral anteversion, and easier revision, all providing flexibility to the surgeon; however, there have been reports of catastrophic fracture, cold welding, and corrosion and fretting of the modular junction.

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Section: Resultsmentioning

confidence: 99%

Proximal Component Modularity in THA—At What Cost?: An Implant Retrieval Study

Kop

Keogh

Swarts

2012

Clinical Orthopaedics &Amp; Related Research

130

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“…The elements in the tested concentrations showed no cytotoxic effect(L. Yang et al, 2010). In another study by Patntirapong et al, calcium phosphate film with Co 2+ incorporation increased both osteoclast differentiation and resorptive function (Patntirapong et al, 2009). …”

Section: Effects Of Biomimetic Apatite Coatings On In Vitro Behaviormentioning

confidence: 91%

“…In addition, cobalt, copper, zinc, strontium and fluoride with varying concentrations were incorporated in the calcium phosphate films by using a biomimetic approach consisting of precalcification and calcification steps. The additives affected morphology and composition of calcium phosphate films to different extent by a dose dependent manner (Patntirapong et al, 2009;L.Yang et al, 2010).…”

Section: Effects Of Trace Elements In Simulated Body Fluid On Biomimementioning

confidence: 99%

Advances in Biomimetic Apatite Coating on Metal Implants

Chaoyong¹,

Fan²,

Zhang³

2011

Advances in Biomimetics

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“…Cobalt ions have been shown to promote the production and release of VEGF from various cell types [12,13] whether the ions were delivered from the dissolution of salts, such as cobalt chloride [11,14], or released from bioactive glasses [15,16]. It has been shown in hMSC that this process was due to the capacity of the cobalt ions released from BG to activate the HIF-1 pathway [15].…”

Section: Dental Stem Cells Secrete Increased Level Of Vegf In Responsmentioning

confidence: 99%

Hypoxia-mimicking bioactive glass regenerative effects on dental stem cells

Noor

Azevedo

Mohamad

et al. 2016

AIP Conference Proceedings

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Abstract.Vascularization is an important aspect of tissue regeneration. Hypoxia, low oxygen concentration, is a known stimulus for the release of vascular endothelial growth factors (VEGF) which play important roles in vascularization. The current study aimed to assess the effect of a cobalt-containing bioactive glass (BG) in stimulating hypoxia and promoting vascularization. To incorporate cobalt into BG, 1 mol% of calcium was substituting with cobalt, and this formulation was compared to the one without cobalt. Both BGs were processed via melt-derived method. The BG powders with particle size less than 38 μm were incubated with cell culture medium for 4 hours at 37°C on continuous rolling, and then the medium was filtered using 0.22 μm syringe filters. Prior to use, the BG-conditioned media were supplemented with 10% (v/v) fetal bovine serum and 1% (v/v) antibiotic-antimycotic, and were allowed to equilibrate overnight inside a CO2 incubator. The conditioned media were used on human dental stem cells (stem cells from permanent (DPSC) and deciduous (SHED) teeth) and assessed for their capacity to stimulate the release of angiogenic factors from the cells. The results showed that cobalt ions were released from the cobalt-containing BG, following partial dissolution of the glasses in cell culture medium, and promoted VEGF release from the cells. In conclusion, the incorporation of cobalt in BG may have potential to be used for tissue regeneration by promoting vascularization through the activation of hypoxia pathway and the release of VEGF.

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Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

Cited by 103 publications

References 49 publications

Proximal Component Modularity in THA—At What Cost?: An Implant Retrieval Study

Proximal Component Modularity in THA—At What Cost?: An Implant Retrieval Study

Advances in Biomimetic Apatite Coating on Metal Implants

Hypoxia-mimicking bioactive glass regenerative effects on dental stem cells

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