Effects of some antibiotics on platelet function in vitro and in vivo

Johnsson, Hans; Niklasson, Per-Magnus

doi:10.1016/0049-3848(77)90042-1

Cited by 11 publications

(8 citation statements)

References 14 publications

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“…ADP-and collagen-induced platelet aggregation was inhibited. Contrary to earlier reports [15], in our experiments the hemostatic defect caused by the tested antibiotics was present after administration of doses often used in clinical practice. The concentration of the compounds in the rat serum did not exceed those seen in patients.…”

Section: Discussioncontrasting

confidence: 55%

“…Administration of large doses of carbenicillin to normal subjects prolonged bleeding time, impaired platelet aggregation and decreased clot retraction as well as prothrombin consump tion [7], Similar results were reported by Cazenave et al [8,9] in in vitro and in vivo studies on the effects of penicillin G on human platelets. [15] demonstrated in vitro that high concentrations of carbenicillin, benzylpenicillin and ampicillin impaired ADP-, collagen-and adrenalin-induced platelet aggregation in human plasma and prolonged thrombin clotting time. When carbenicillin and benzylpenicillin were administered in vivo to defibrinogenated dogs, bleeding time from standardized wounds was increased and thrombinmediated platelet aggregation in dog plasma was depressed [15].…”

Section: Discussionmentioning

confidence: 99%

“…[15] demonstrated in vitro that high concentrations of carbenicillin, benzylpenicillin and ampicillin impaired ADP-, collagen-and adrenalin-induced platelet aggregation in human plasma and prolonged thrombin clotting time. When carbenicillin and benzylpenicillin were administered in vivo to defibrinogenated dogs, bleeding time from standardized wounds was increased and thrombinmediated platelet aggregation in dog plasma was depressed [15]. The mech anism by which these compounds affect hemostasis has not been clarified.…”

Section: Discussionmentioning

confidence: 99%

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Defects in Hemostasis Produced by Antibiotics

Bengmark¹,

Göransson²,

Zoucas³

1981

Eur Surg Res

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The effect of preoperative infusion of benzylpenicillin, carbenicillin, ampicillin, chloramphenicol and doxycycline on hemostasis after standardized liver resection was studied in the rat. Plasma levels of each antibiotic were within the range of those found after administration of therapeutic doses in man. Bleeding time was prolonged and blood loss was increased in all cases of antibiotic administration compared with controls. APT time after liver resection was prolonged in the carbenicillin- and chloramphenicol-treated groups. Platelet function, assayed by ADP- and collagen-induced platelet aggregation was impaired in benzylpenicillin-, carbenicillin- and chloramphenicol-treated animals.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Defects in Hemostasis Produced by Antibiotics

Bengmark¹,

Göransson²,

Zoucas³

1981

Eur Surg Res

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“…Platelet-rich plasma (PRP), platelet-poor plasma (PPP), thrombin clotting time, reptilase clotting time and platelet counts were determined as previously described (17). Platelet aggregation was determined turbidimetrically (17).…”

Section: Laboratory Studiesmentioning

confidence: 99%

Clinical and Experimental Evaluation of the Thromboprophylactic Effect of Hydroxychloroquine Sulfate after Total Hip Replacement

Johansson¹,

Forsberg²,

Johnsson³

1981

Pathophysiol Haemos Thromb

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The rate of postoperative deep vein thrombosis was studied by the ¹²⁵I-fibrinogen method in 35 patients after total hip replacement. 12 out of 18 patients treated prophylactically with hydroxychloroquine sulfate developed deep vein thrombosis compared with 11 out of 17 patients in the control group. Platelet aggregability was inhibited in vitro by high concentrations of hydroxychloroquine sulfate, but these concentrations were not obtained in vivo and platelet aggregation was not inhibited in patients treated with hydroxychloroquine sulfate (Plaquenil®).

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“…Several cephalosporin antibiotics have been shown to induce defects in hemostasis (1,2,10,12). We therefore examined the effect of the new cephalosporin, cefamandole nafate (Mandol), on platelet function and coagulation.…”

mentioning

confidence: 99%