the meninges and abducens nerve on its long intracranial course. The sixth nerve occupies a superficial position in relation to the fourth ventricle, which communicates directly through the foramina of Magendie and Luschka with the subarachnoid space. Dye studies have shown that agents introduced into the spinal canal frequently reach the medulla, which may explain the peculiar affinity of the sixth nerve to palsy.4 The contrast agents introduced in the procedure of myelography have a toxicity of their own, and the incidence of cranial nerve palsy is higher than after merely dural puncture.5 This may be due to a previously unreported direct neurotoxicity of the contrast agent iopamidol itself.

In a prospective controlled study we evaluated the effect of early norfloxacin treatment on the duration of salmonella carriage after acute salmonellosis. The study was carried out during an outbreak of Salmonella typhimurium infection at a military base. 23 patients received norfloxacin 400 mg twice daily for 7 days while 29 patients served as untreated controls. A patient was considered to have ceased being a carrier on the date of the first of 3 negative consecutive cultures. Four weeks after diagnosis 30% of the treated patients and 31% in the control group were still carriers. The corresponding figures after 8 and 12 weeks were 17 and 3% and 4 and 0%, respectively. Thus, one week of norfloxacin treatment instituted at an early stage of salmonellosis did not shorten the duration of carriage.

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